What is role of Alkylating Agents in treatment of Cancer?

why alkylating agents are widely used in cancer treatment
13-02-2017

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khushia 13-02-2017
khushia - University of Lucknow
These are also called as polyfunctional alkylating agents.They act on DNA, RNA and as well as some certain enzymes. The alkylating agents are thought to react with the 7 position of guanine in each of the double strands of DNA causing cross linking. This interferes in the separation of the strands and prevents mitosis.Details on these agents at: http://www.docsity.com/en/medicinal-chemistry-unit-drug-design/866450/
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