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*1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT V, Exams of Nursing

*1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS

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Download *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT V and more Exams Nursing in PDF only on Docsity! *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS sympathetic nervous system NTs/receptors/effects - CORRECT ANSWERS Epi/NE alpha/beta (adrenergic) ↑ BP, HR, bronchodilation muscarinic agonists (2) and antagonists (2) - CORRECT ANSWERS agonists: pilocarpine, bethanechol antagonists: atropine, oxybutynin nicotinic agonist and antagonist - CORRECT ANSWERS agonist: nicotine antagonist: rocuronium α-1 agonists (2) and antagonists (3), actions - CORRECT ANSWERS peripheral agonists: phenylephrine, DA (dose-dependent) → smooth muscle vasoconstriction antagonists: doxazosin, carvedilol, phentolamine → vasodilation α-2 agonists (2) and antagonists (2), actions - CORRECT ANSWERS brain/CNS agonists: clonidine, brimonidine → decrease Epi/NE release antagonists: ergot alkaloids, yohimbine β-1 agonists (3) and antagonists (3) - CORRECT ANSWERS heart agonists: dobutamine, isoproterenol, DA (dose-dependent) antagonists: metoprolol, propranolol, carvedilol β-2 agonists (3) and antagonists (2) - CORRECT ANSWERS lungs agonists: albuterol, terbutaline, isoproterenol antagonists: propranolol, carvedilol DA agonists (2) and antagonists (2) - CORRECT ANSWERS renal, CV, CNS *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS agonists: levodopa, pramipexole antagonists: FGAs/haloperidol, metoclopramide 5HT agonist (1) and antagonists (2) - CORRECT ANSWERS platelets, GI, CNS agonists: triptans antagonists: ondansetron, SGAs/quetiapine AChEIs (3), action - CORRECT ANSWERS donepezil, rivastigmine, galantamine block breakdown of ACh (Alzheimer's) ACEI effects - CORRECT ANSWERS decrease vasoconstriction and aldosterone release (HTN, HF, CKD) COMT inhibitor, effect - CORRECT ANSWERS entacapone block breakdown of levodopa (PD) NSAID action, effect - CORRECT ANSWERS block COX from converting arachidonic acid to prostaglandins (inflammation) and TXA2 (platelet aggregation) MAOIs (7), action, effects - CORRECT ANSWERS phenelzine, tranylcypromine, isocarboxazid, selegiline, rasagiline, methylene blue, linezolid - block breakdown of catecholamines (DA, NE, Epi, 5HT) - additive increase → HTN crisis - increased 5HT → serotonin syndrome PDE-5 inhibitors, effect - CORRECT ANSWERS -afil block breakdown of cGMP for prolonged smooth muscle relaxation (ED) warfarin action - CORRECT ANSWERS blocks vitamin K epoxide reductase → Vit K not active → reduced clotting factors *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS common CYP inhibitors (7) - CORRECT ANSWERS G PACMAN: Grapefruit Protease inhibitors azoles cyclosporine macrolides amiodarone non-DHP CCBs common CYP inducers (7) - CORRECT ANSWERS PS PORCS: - Phenytoin - Smoking - Phenobarbital - Oxcarbazepine - Rifampin - Carbamazepine - St. John's Wort P-gp substrates (7) - CORRECT ANSWERS apixaban rivaroxaban digoxin NDHP CCBs cyclosporine tacrolimus colchicine P-gp inducers (5) - CORRECT ANSWERS carbamazepine phenobarbital phenytoin *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS rifampin St. John's wort P-gp inhibitors (4) - CORRECT ANSWERS amiodarone NDHP CCBs cobicistat/ritonavir cyclosporine amiodarone DDIs - CORRECT ANSWERS inhibits 2C9 → increases warfarin inhibits P-gp → increases digoxin avoid 3A4 inhibitors with (2) - CORRECT ANSWERS lovastatin, simvastatin 2D6 substrate prodrugs - CORRECT ANSWERS codeine tramadol avoid 3A4, p-gp inducers with - CORRECT ANSWERS calcineurin inhibitors/mTOR kinase inhibitors (transplant rejection) drugs that increase risk of serotonin syndrome (6) - CORRECT ANSWERS antidepressants MAOIs opioids triptans St. John's wort L-tryptophan drugs that increase K - CORRECT ANSWERS RAAS drugs (no ACEI + ARB) K-sparing diuretics *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS drugs that prolong QT - CORRECT ANSWERS antiarrhythmics anti-infectives antidepressants (sertraline safest SSRI) antipsychotics antiemetics oncology meds drugs that cause ototoxicity (5) - CORRECT ANSWERS aminoglycocides cisplatin loop diuretics salicylates vancomycin drugs that cause nephrotoxicity (6) - CORRECT ANSWERS anti-infectives cisplatin calcineurin inhibitors loop diuretics NSAIDs contrast dye drugs that cause anticholinergic toxicity (6) - CORRECT ANSWERS antidepressants antipsychotics sedating antihistamines centrally-acting anticholinergics muscle relaxants antimuscarinics drugs combos that can cause orthostasis - CORRECT ANSWERS PDE-5 inhibitors 3A4 inhibitor *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS conditions that increase BUN (2) - CORRECT ANSWERS renal impairment and dehydration drugs that increase SCr (11) - CORRECT ANSWERS aminoglycosides amphotericin B cisplatin colistimethate cyclosporine loop diuretics polymyxin NSAIDs radiocontrast dye tacrolimus vancomycin an anion gap increase suggests - CORRECT ANSWERS metabolic acidosis drugs that increase (1)/decrease (4) WBCs - CORRECT ANSWERS increase: systemic steroids decrease: clozapine, chemotherapy, carbamazepine, immunosuppressants neutrophils - CORRECT ANSWERS PMNs, polys, segs bands - CORRECT ANSWERS immature neutrophils elevation = left shift infection conditions that increase eosinophils (3) - CORRECT ANSWERS asthma inflammation parasitic infection *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS conditions that increase basophils - CORRECT ANSWERS hypersensitivity conditions/drugs that increase (2)/decrease (3) lymphocytes - CORRECT ANSWERS increase: viral infection, lymphoma decrease: bone marrow suppression, HIV, systemic steroids RBC avg lifespan - CORRECT ANSWERS 120 days drugs/conditons that increase (1)/decrease (2) RBCs/Hgb - CORRECT ANSWERS increase: ESAs decrease: chemo, anemias conditions that increase/decrease MCV - CORRECT ANSWERS increase (macrocytic anemia): B12/folate deficiency decrease (microcytic anemia): iron deficiency drugs that decrease folic acid/folate (5) - CORRECT ANSWERS phenytoin/fosphenytoin phenobarbital primidone methotrexate Bactrim drugs that decrease Vit B12 (2) - CORRECT ANSWERS PPIs metformin Coombs test - CORRECT ANSWERS a blood test to diagnose hemolytic anemias drugs that cause hemolytic anemia (9); may also be triggered by _________________ - CORRECT ANSWERS penicillins, cephalosporins, isoniazid, levodopa, methyldopa, quinidine, quinine, rifampin, sulfonamides *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS G6PD deficiency (fava beans, dapsone, methylene blue, nitrofurantoin, pegloticase, primaquine, rasburicase) Anti-factor Xa, use, when to take - CORRECT ANSWERS monitor LMWHs, UFH (pregnancy) - 4h after LMWH - 6h after UFH IV start monitor warfarin - CORRECT ANSWERS PT/INR INR may increase with this condition (1) and these drugs (3) - CORRECT ANSWERS liver disease false increase: daptomycin oritavancin telavancin aPTT and PTT to monitor what? when? falsely elevated by (2)? - CORRECT ANSWERS UFH 6h after IV start oritavancin, telavancin Platelet life span, drugs that decrease (5) - CORRECT ANSWERS 7-10 days UFH/LWMH fondaparinux linezolid valproic acid HIT - CORRECT ANSWERS heparin induced thrombocytopenia platelet drop of 50% on UFH or LMWH ELISA antibody testing then confirm with serotonin release assay (SRA) *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS BPH hCG indicates - CORRECT ANSWERS pregnancy drugs that increase lactic acid/lactate (2) - CORRECT ANSWERS NRTIs metformin drugs that increase prolactin (2) - CORRECT ANSWERS FGA/haloperidol risperidone/paliperidone thiopurine methyltransferase (TPMT) - CORRECT ANSWERS deficiency increases risk of myelosuppression lower dose of azathioprine, mercaptopurine Carbamazepine therapeutic range - CORRECT ANSWERS 4-12 mcg/mL Digoxin therapeutic ranges - CORRECT ANSWERS 0.8-2 ng/mL (AFib) 0.5-0.9 ng/mL (HF) gentamicin/tobramycin traditional therapeutic range - CORRECT ANSWERS peak: 5-10 mcg/mL trough: <2 mcg/mL Lithium therapeutic range - CORRECT ANSWERS 0.6-1.2 mEq/L (trough) Phenytoin/Fosphenytoin therapeutic range - CORRECT ANSWERS 10-20 mcg/mL correct for low albumin free: 1-2.5 mcg/mL Procainamide therapeutic range - CORRECT ANSWERS 4-10 mcg/mL *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS NAPA: 15-24 Combined: 10 - 30 Theophylline therapeutic range - CORRECT ANSWERS 5-15 mcg/mL Valproic acid therapeutic range - CORRECT ANSWERS 50-100 mcg/mL Vancomycin therapeutic range - CORRECT ANSWERS trough 15-20 mcg/mL for most serious infections, 10-15 for others warfarin goal INR - CORRECT ANSWERS 2-3 2.5-3.5 if mechanical valves Where can package inserts be found? - CORRECT ANSWERS DailyMed (NLM) Drugs@FDA boxed warning - CORRECT ANSWERS risk of death or permanent disability Warning and precautions - CORRECT ANSWERS serious reactions that may result in death, hospitalization, medical intervention, disability or teratogenicity anticoagulation guidelines - CORRECT ANSWERS CHEST (American College of Chest Physicians) CV disease guidelines - CORRECT ANSWERS American College of Cardiology/American Heart Association (ACC/AHA) Diabetes guidelines - CORRECT ANSWERS American Association of Clinical Endocrinologists (AACE) American Diabetes Association (ADA) *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS infectious disease guidelines - CORRECT ANSWERS Infectious Disease Society of America (IDSA) HIV/AIDS: US DHHS STIs: CDC oncology guidelines - CORRECT ANSWERS American Society of Clinical Oncology (ASCO) National Comprehensive Cancer Network (NCCN) pediatric guidelines - CORRECT ANSWERS American Academy of Pediatrics (AAP) Pregnancy/Women's Health Guidelines - CORRECT ANSWERS The American College of Obstetricians and Gynecologists (ACOG) Psychiatric guidelines - CORRECT ANSWERS American Psychiatric Association (APA)- Diagnostic and Statistical Manual of Mental Disorders - 5th edition (DSM-5) Pulmonary guidelines - CORRECT ANSWERS Asthma: Global Initiative for Asthma (GINA) COPD: Global Initiative for Chronic Obstructive Lung Disease (GOLD) Renal guidelines - CORRECT ANSWERS Kidney Disease Improving Global Outcomes (KDIGO) vaccine guidelines - CORRECT ANSWERS Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control (CDC) ADR references - CORRECT ANSWERS ASHP FDAble/MedWatch/FAERS VAERS Compounding/Pharmaceutics references (11) - CORRECT ANSWERS - Allen's *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS ¨ Harriet Lane Handbook ¨ American Academy of Pediatrics (AAP) pharmacology reference - CORRECT ANSWERS Goodman and Gilman's Pregnancy/lactation references - CORRECT ANSWERS Brigg's CDC Hale's LactMed Micromedex (Reprotox, Reprorisk) Regulatory and business development references - CORRECT ANSWERS FDA Center for Drug Evaluation and Research (CDER) Pink Sheet Therapeutics and Disease Management References - CORRECT ANSWERS - DiPiro's - Handbook of Nonprescription Drugs - Koda-Kimble's - Merck Manual - UpToDate veterinary references - CORRECT ANSWERS Plumb's FDA's Green Book Locating Clinical Study Data and Research Summaries - CORRECT ANSWERS PubMed Cochrane Library consumer resources - CORRECT ANSWERS · CDC - infectious diseases, immunizations, traveler's health · Drug.com, RxList *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS · Mayo Clinic · MedlinePlus (NLM) · WebMD - has pill identifier, interaction checker long-acting drug formulations - CORRECT ANSWERS pros: long DOA, reduced ADRs do not crush/chew (some caps can be sprinkled) what long-acting meds can be cut on score line? (2) - CORRECT ANSWERS Toprol XL carbidopa/levodopa ER suspension and solution formulations - CORRECT ANSWERS children shake suspensions, not solutions chewable formulations - CORRECT ANSWERS children also Ca lozenge/troche formulations - CORRECT ANSWERS treat oral mucosa ODT formulations - CORRECT ANSWERS disintegrate in saliva pros: dysphagia, stroke, children, nausea, non-adherence counsel: peel back foil, place on tongue to dissolve, then swallow SL, buccal formulations - CORRECT ANSWERS faster onset, less GI degradation/1st pass metabolism granule/powder/sprinkle formulations - CORRECT ANSWERS pediatric/geriatric/NG tube counsel: no warm/hot, only specific foods, don't let mixture sit Montelukast granules administration (4) - CORRECT ANSWERS can be mixed with spoonful of applesauce, carrots, rice or ice cream *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS Lisdexamfetamine (Vyvanse) administration (3) - CORRECT ANSWERS can be mixed in water, yogurt, or orange juice sweetener caution - CORRECT ANSWERS sorbitol: gas/cramping/bloating phenylalanine/aspartame: phenylketonuria lactose general sites for patches (4) - CORRECT ANSWERS chest back upper arms flanks (no Exelon) Daytrana patch location - CORRECT ANSWERS hip Transderm Scop patch location - CORRECT ANSWERS behind the ear BID patch - CORRECT ANSWERS diclofenac daily patches (6 + 2) - CORRECT ANSWERS methylphenidate nicotine rivastigmine rotigotine selegiline testosterone lidocaine (12 on, 12 off) nitroglycerine (12-24 on, 10-12 off) Q72H patches (2) - CORRECT ANSWERS fentanyl *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS calcium + phosphate filters for parenteral meds - CORRECT ANSWERS 0.22 1.2 for PN, lipid emulsion drugs that require a filter - CORRECT ANSWERS GAL IM PAT (and I need a filter) + PN · Golimumab · Amphotericin B (lipid formulation) · Lipids · Isavuconazonium · Mannitol 20%+ · Phenytoin (if CIVI) · Amiodarone · Taxanes · Parenteral nutrition Do not refrigerate drugs - CORRECT ANSWERS Dear Sweet Pharmacist, Freezing Makes Me Edgy Dexmedetomidine Sulfamethoxazole-TMP Phenytoin Furosemide Metronidazole Moxifloxacin Enoxaparin Protect from light drugs - CORRECT ANSWERS Protect Every Necessary Med from Daylight Phytonadione *1* NAPLEX EXAM REVIEW - PHARMACY FOUNDATIONS PART 1 (CH 2-8) EXAM QUESTIONS AND CORRECT VERIFIED ANSWERS LATEST UPDATE 2023/2024 BEST EXAM SOLUTION TOP RANKED TO SCORE A+ FOR SUCCESS Epoprostenol Nitroprusside Micafungin Doxycycline do not shake drugs - CORRECT ANSWERS Hormones and proteins albumin, immune globulin, mAbs, insulin, reconstituted vaccines swirl: alteplase, etanercept, rasburicase colored IV solutions - CORRECT ANSWERS red: anthracyclines/rifampin blue: mitoxantrone nitroprusside IV degradation - CORRECT ANSWERS dissociates to cyanide (blue) who qualifies for Medicare and Medicaid? - CORRECT ANSWERS Medicare: 65+, disabled, ESRD Medicaid: low income temperature conversion - CORRECT ANSWERS C = (F-32)/1.8
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