What are the major factors for the optimal structure of a database?

Can some one provide the factors of producing a optimal structure of a database?
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"A given database management system may provide one or more of the five models. The optimal structure depends on the natural organization of the application's data, and on the application's requirements, which include transaction rate (speed), reliability, maintainability, scalability, and cost. Source: http://in.docsity.com/en-docs/Database_Management_System-Introduction_to_Computing-Handout_"
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Any integrated list of data held in a pc, esp. engineered to be easily obtainable in ways
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