"What factors predispose some people to become and remain obese?"

"I would be grateful if someone could tell me factors predispose some people to become and remain obese."
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"The lack of exercise combined with the abundance of highcalorie food has led to increased rates of obesity, showing the influence of environment. Twin and adoption studies indicate that body weight is also genetically influenced (in the number of fat cells and basal metabolic rate). Thus, genes and environment interact to produce obesity. Those wishing to lose weight are advised to make a lifelong change in habits, minimize exposure to tempting food cues, boost energy expenditure through exercise, eat healthy foods, space meals throughout the day, beware of the binge, and forgive the occasional lapse."
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To make (someone) inclined to something in advance: His good manners predispose people in his favor.
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