ABGC Practice Exam Test 1 Cancer Questions With 100% Correct And Verified Answers 2024, Exams of Advanced Education

Download ABGC Practice Exam Test 1 Cancer Questions With 100% Correct And Verified Answers 2024 and more Exams Advanced Education in PDF only on Docsity! ABGC Practice Exam Test 1 Cancer Questions With 100% Correct And Verified Answers 2024 A 45yearold man with colon cancer comes for genetic counseling. In conjunction with microsatellite instability testing, which of the following tests done on his colon tumor would be MOST helpful in deciding about testing for germline Lynch syndrome mutations? A. comparative genomic hybridization B. tumor cell karyotype C. immunohistochemical staining D. loss of heterozygosity - Correct Answer-C. immunohistochemical staining A 43yearold woman seeks genetic counseling because of a recent diagnosis of endometrial cancer. Her family history includes a maternal grandmother with breast cancer at age 56, father with colorectal cancer at age 47, and one paternal aunt with ovarian cancer at age 49. Counseling regarding testing for which of the following syndromes is MOST appropriate? A. familial adenomatous polyposis B. hereditary breast and ovarian cancer C. hereditary nonpolyposis colorectal cancer D. PTEN hamartoma tumor syndrome - Correct Answer-C. hereditary nonpolyposis colorectal cancer A 30yearold woman with a family history of breast cancer comes to the genetics clinic for BRCA1 and BRCA2 testing. Her mother was diagnosed with breast cancer at 45. Her family history also includes a paternal aunt with breast cancer diagnosed at 68 and a maternal first cousin with breast cancer diagnosed at 35. To clarify the woman's risk, which of the following individuals should be tested FIRST? A. the paternal aunt B. her mother C. her other paternal aunt who has no history of cancer D. the maternal first cousin with breast cancer - Correct Answer-B. her mother A couple comes for preconception genetic counseling because the woman had bilateral retinoblastoma. The husband asks about his wife's risks for developing the nonocular cancers associated with this disease. The counselor invites the woman to answer in an attempt to assess her level of understanding and perception of risk. She responds in anger, "Do you mind not talking about this?!" Which of the following is the MOST appropriate response by the genetic counselor? A. Explain that her reaction may be a healthy coping mechanism. B. Acknowledge her anger and ask her to elaborate on her reaction. C. Discuss information regarding her increased risk of additional cancers. D. Offer to talk to the husband later in private and redirect the conversation. - Correct Answer-B. Acknowledge her anger and ask her to elaborate on her reaction. A 44yearold man with colon cancer comes for genetic counseling. He has no family history of cancer. His pathology report indicates that his tumor is MSIHigh with the following immunohistochemistry (IHC) results: MLH1 present MSH2 present MSH6 present PMS2 present During the preauthorization process, the genetic counselor learns that the patient will have to pay for followup molecular testing out of pocket and can afford testing for only two genes. In addition to MLH1, which of the following genes should be tested to identify the causative mutation? A. EPCAM B. MSH2 C. MSH6 D. PMS2 - Correct Answer-B. MSH2 A 55yearold woman with thyroid cancer is referred for genetic counseling. Her medical history includes surgical excision of a growth on her neck and excision of colon polyps at age 50. She was adopted, and her family history is not available. Which of the following would be the MOST compelling additional information to support testing for mutations in the PTEN gene? A. Her first son was born at 36 weeks gestation. B. The growth excised from her neck was a sarcoma. C. Her head circumference is above the 98th percentile. D. The polyps were hamartomas. - Correct Answer-C. Her head circumference is above the 98th percentile. A 38yearold woman with breast cancer comes for genetic counseling. Her mother died of ovarian cancer at age 35. The woman states that she is fearful her 19yearold daughter will develop cancer and wants to know what testing options are available. Which of the following is the genetic counselor's BEST response? A. "To accurately determine your daughter's risk for cancer, you must have genetic testing first." B. "To confirm your mother's diagnosis, we need a copy of her pathology report." C. "It's understandable to worry about your daughter; we can test her because she is an adult." his daughters to be tested for the mutation. Which of the following is the BEST next step by the genetic counselor? A. Ask the father about his motivation for requesting genetic testing of his daughters. B. Discuss with the father the options for medical management should breast cancer arise in his daughters. C. Explain the insurance implications of a positive result. D. Arrange genetic testing for the 17yearold daughter. - Correct Answer-A. Ask the father about his motivation for requesting genetic testing of his daughters. A 45yearold woman with premenopausal breast cancer comes for genetic counseling. She says that her mother died of "abdominal cancer" at age 65 years. The patient has been estranged from her family since several years before her mother's death and remembers only vague details about her mother's illness. Which of the following is the MOST appropriate next step by the counselor to establish the diagnosis in the mother? A. Have the patient obtain her mother's death certificate. B. Ask the patient to identify a family member who is more familiar with her mother's medical history. C. Note the cancer in her record and continue to facilitate recall of other family cancers. D. Request the deceased woman's medical records from her treating physician because consent is not required when a provider is the requestor. - Correct Answer-D. Request the deceased woman's medical records from her treating physician because consent is not required when a provider is the requestor. A 45yearold man is referred for genetic counseling because he has pancreatic cancer. Review of his medical record indicates that he also had a melanoma. He is MOST likely to have a mutation in which of the following genes? A. BRCA1 B. CDKN2A C. PTEN D. TSC2 - Correct Answer-B. CDKN2A A 12yearold girl is referred for a genetic evaluation to rule out a syndrome after having been diagnosed with colon polyps. The abnormal results of which of the following would be MOST supportive of a diagnosis of familial adenomatous polyposis? A. ophthalmologic evaluation B. audiologic testing C. brain MRI D. abdominal ultrasound - Correct Answer-A. ophthalmologic evaluation A Caucasian genetic counselor meets with a Hispanic woman who is being evaluated for familial adenomatous polyposis. In an attempt to gain the client's trust and to promote their engagement, the counselor begins the conversation by sharing information about her own family's experience with cancer. This counseling technique is based on A. attending language. B. congruence. C. shared language. D. reciprocity. - Correct Answer-D. reciprocity.