BIOLOGY EDEXCEL IAL UNIT 1 - PAST PAPER QUESTIONS WITH 100% SOLUTION, Exams of Nursing

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Bonding in unsaturated lipids - Correct Answers ✅have double bonds between C atoms and between C and O atoms. method of amniocentesis and how its used to detect CF. - Correct Answers ✅1) amniotic fluid removed (from amniotic sac of the mother) / eq.

2. {fetal/embryonic} cells present in amniotic fluid /{fetal / embryonic} cells needed.
3. DNA can be analysed/ eq.
4. to detect {defective/eq} gene(s) (in sample)/ eq. method of chorionic villus sampling and how its used to detect CF. - Correct Answers ✅1) placental tissue removed (from the womb of the mother) / eq.
5. fetal cells present in {placenta/placental tissue / chorionic tissue} / fetal cells are needed.
6. DNA can be analysed / eq.
7. to detect {defective / eq} gene(s) (in sample) / eq. benefits, to a pregnant woman, of prenatal testing. - Correct Answers ✅1) it gives information about abnormalities in the fetus/eq.

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2. {opportunity for choice/eq} OR {consider termination/eq} OR time for {preparation/treatment/eq}. risks, to a pregnant woman, of prenatal testing. - Correct Answers ✅1) possibility of miscarriage due to procedure/eq.
3. potentially a healthy baby would be lost/eq} / {risk to mother / eq}. OR
4. idea of a false positive/negative result.
5. a wrong decision made. OR
6. damage/harm to the fetus.
7. subsequent health issues/miscarriages/eq. Ethical and social issues relating to the use of prenatal testing. - Correct Answers ✅1) idea that fetus is living
8. abortion is wrong/murder/eq.
9. who has the right to decide id tests should be performed/eq.
10. implications of medical costs/disagreements over the next step.

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1. who has the right to make the decision for the fetus/ fetus has rights.
2. the fetus is being denied the opportunity to live/ fetus has a right to live. Describe the roles of the atrioventricular valves during the cardiac cycle. - Correct Answers ✅1) valves separate atria from ventricles.
3. opens during atrial systole/contraction / eq.
4. so that blood can pass through to the ventricles / eq.
5. closed during ventricular systole/contraction / eq.
6. to prevent back flow into atria + to maintain pressure in ventricles.
7. open during diastole.
8. so that ventricles can start to fill up as atria are filling. Suggest reasons for the difference in the maximum pressures of the left and right ventricles. - Correct Answers ✅1) pressure in left is higher than right.
9. left ventricles pumps blood all around body / eq.
10. right ventricles pumps blood to lungs / eq.
11. if blood from right ventricle at high pressure there would be damage to lungs/capillaries / eq.
12. lots of muscle/thick wall of left ventricle.

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Define causation - Correct Answers ✅when a change in one variable is responsible for a change in another variable. define correlation - Correct Answers ✅relationship between 2 variables such that a change in one of the variables is reflected by a change in the other variable / eq. define gene - Correct Answers ✅a section of DNA/ sequence of bases that codes for a polypeptide / eq. and occupies a particular locus on a chromosome. define allele - Correct Answers ✅different/variant form of a gene. define recessive allele - Correct Answers ✅allele that is only expressed in the phenotype of an organism if the dominant allele is not present / eq. define homozygous - Correct Answers ✅alleles of a particular gene are the same / eq. amylose is an example of a: - Correct Answers ✅polysaccharide

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The three dimensional structure of a protein is held together by: - Correct Answers ✅. disulphide bridges.

. hydrogen bonds. . ionic bonds. What blood vessel carries deoxygenated blood to the lungs? - Correct Answers ✅pulmonary artery. Define activation energy - Correct Answers ✅1) energy needed for a reaction to occur.

2. by causing bonds to break/weaken/form.
3. by increasing the number of collisions / eq. Explain why it is necessary to measure the initial rate of reaction when investigating the effect of enzyme concentration on the rate of reaction. - Correct Answers ✅1) there should be enough substrate molecules to saturate the enzyme.
4. to endure that the substrate is not a limiting factor / eq.

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Factors that increase the risk of CVDs - Correct Answers ✅1) genetics.

2. diet.
3. increasing age.
4. male.
5. high BP.
6. smoking.
7. inactivity/lack of exercise. advantages of the human circulatory system - Correct Answers ✅1) blood flows {faster/at higher pressure/eq} (to the body).
8. blood flows {slower/at lower pressure/eq} to the lung.
9. idea that this reduces risk of damage to lungs.
10. correct ref. to more efficient {exchange/ transport} of gases / eq. Describe the structure of an enzyme. - Correct Answers ✅1) ref to an enzyme as a protein.
11. ref. to {3D/tertiary/globular} structure.
12. ref. to named bonds (holding structure in place).
13. between the R groups.

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5. ref. to active site.
6. idea of specificity of active site. Describe the blood clotting process. - Correct Answers ✅1) idea that there is a cascade of events (leading to blood clotting).
7. ref. to thromboplastin (starting the cascade).
8. ref. to conversion of prothrombin into thrombin.
9. idea that {thromboplastin/thrombin} is {an enzyme / a catalyst} ;
10. ref. to conversion of fibrinogen into fibrin.
11. ref. to formation of mesh of {fibres/fibrin}.
12. ref. to requirement of {calcium ions/ Ca2+ / vitamin K} ;
13. ref. to {platelets/blood cells} getting trapped (in the mesh) ; Suggest why cells from mouth swabs or blood samples are used rather than gametes - Correct Answers ✅1) idea that these cells are {easy/painless } to collect.
14. idea that a relatively {large amount of DNA / large number of cells} can be collected.
15. they {contain diploid cells/have (23) pairs of chromosomes}.

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4. cells {are genetically identical/have same DNA / have same alleles}.
5. any {recessive allele/mutated (CF) gene} will be present in them / eq.
6. idea that if the gametes were tested they may not contain the {recessive allele/mutated (CF) gene} (as they are haploid). Explain why it is necessary to test for several different recessive alleles in the screening for CF. - Correct Answers ✅1) cystic fibrosis results from one of a number of possible mutations (of this gene) /eq.
7. idea that testing for only one will miss other recessive alleles. Explain why the probability of having a child with CF is low and not zero when both parents aren't carriers. - Correct Answers ✅1) ref. to false negatives/eq.
8. idea that the screening programme does not test for all the possible mutations that can cause cystic fibrosis.
9. idea that a mutation may occur in the formation of the gametes.
10. idea of mutation in both gametes.
11. idea that a mutation may occur after fertilisation. Explain why family members of CF carriers are offered genetic screening. - Correct Answers ✅1) idea that any other family member could be a carrier.

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2. idea that informed choices can be made about having children (if they know that they are carriers). Function of semi-lunar valves - Correct Answers ✅1) prevents back flow of blood into heart ventricles.
3. during diastole/atrial systole. Explain why a mammalian heart is divided into a right side and a left side - Correct Answers ✅1) idea that it keeps oxygenated and deoxygenated blood separate.
4. idea that this results in as much oxygen as possible being carried to the tissues/cells.
5. reference to need for different pressures in each side. Risk of using antihypertensives - Correct Answers ✅blood pressure falls too low / coughs / swelling of ankles / impotence / tiredness / constipation / headache / confusion / depression / excessively low heart rate / allergy / stroke / provoked type II diabetes / frequent urination / fainting / dizziness / vomiting / dry mouth / breathing difficulties / irregular heart rate / chest pain / hives / rash / dehydration / reduced circulation effects / low potassium / blurred vision / eq.

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Explain the meaning of the term primary structure. - Correct Answers ✅1) sequence of amino acids

2. joined by peptide bonds. Explain the importance of the primary structure of an enzyme to its function. - Correct Answers ✅1) idea that primary structure determines (three-dimensional) folding/ eq.
3. reference to types of amino acids determine types of bonds formed.
4. reference to position of amino acids determines position of {bonds / correctly named bond}.
5. idea that {shape/position/eq} of active site is determined by position of amino acids.
6. reference to shape of active site being correct to bind to substrate.
7. reference to {amino acids/R groups} involved in {chemical reaction/ eq}.

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7. reference to {globular/soluble/enzyme} molecules being {relatively short/small/made up of relatively few amino acids}.
8. reference to {globular/soluble proteins/enzyme} having relatively high number of {polar/ small {amino acids/R groups}.
9. reference to {polar R groups/eq} facing outwards. Roles of mRNA in protein synthesis. - Correct Answers ✅1) reference to mRNA as a copy of the {genetic code/DNA}.
10. holds the information of the protein (being synthesised)/eq.
11. moves out of the nucleus/to ribosomes/ eq.
12. idea that it acts as a template/has the instructions for translation. Roles of tRNA in protein synthesis. - Correct Answers ✅1) correct reference to translation.

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2. binds to an amino acid/takes the amino acid to the ribosome/mRNA.
3. reference to tRNA being specific to amino acid.
4. holds the amino acid in place/eq. Describe the process of protein synthesis that occurs in the cytoplasm. - Correct Answers ✅1) reference to ribosome (attaches to mRNA).
5. idea that tRNA carries an amino acid.
6. idea of{ anti codon codon interaction/complementary base pairing } between tRNA and mRNA.
7. formation of hydrogen bonds (between the tRNA and mRNA).
8. reference to peptide bond (between amino acids).

6. (peptide bond) formed by a condensation reaction.

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7. idea that tRNA released from {mRNA / ribosome).
8. idea that ribosome {attaches to/detaches from/ eq} {sequence / eq} on mRNA. Explain the effect of ethanol on the permeability of beetroot cell membranes. - Correct Answers ✅1) idea that ethanol causes the membrane to be{disrupted/ eq}.

2. idea that this is due (phospho)lipids dissolve in ethanol.
3. idea that (membrane) proteins denatured by ethanol.
4. comment on the disruption of the vacuole membrane/eq.
5. idea that {betalain/pigment}can escape from the {cell/ vacuole /eq } when the membrane is disrupted. Explain why water is an effective molecule for transporting other molecules around living molecules. - Correct Answers ✅1) Idea that water is a solvent.
6. idea that water is {slightly charged/dipole/polar/ eq}.
7. idea that polar molecules/ions/eq. can dissolve in water.
8. idea that water is viscous/fluid/ eq.
9. idea of water as a liquid assists mass flow.

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6. correct reference to cohesion/adhesion. Suggest why a faulty atrioventricular valve could lead to symptoms of breathlessness and lack of energy. - Correct Answers ✅1) valve does not shut properly/eq.
7. some backflow of blood (from ventricle to atrium) / eq.
8. during ventricular systole/ when ventricles contract / eq.
9. idea of lower blood pressure.
10. idea of less efficient supply of oxygen.
11. idea that blood pressure in lungs increases. Explain how the circulatory system in mammals enables efficient gas exchange. - Correct Answers ✅1) idea that mass flow generated by heart.
12. idea that moving blood helps to maintain a concentration gradient.
13. idea that a steep/eq. concentration gradient gives a fast/eq. rate of diffusion.
14. idea of network/lots/e. of capillaries.
15. large surface area of capillaries/eq.
16. idea that large surface area increases the rate of diffusion.
17. idea that capillaries have very thin walls.

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8. idea that diffusion is fastest over small distances.
9. idea that no organs/cells/tissues are far away from blood/capillaries cover alveoli/eq.
10. idea that efficiency is related to double circulation. Explain why the combination of a high-fat diet and low activity levels may lead to CVD. - Correct Answers ✅1) idea of energy imbalance.
11. idea of individual becoming overweight / obese / eq.
12. idea of increased blood pressure.
13. idea of obesity leads to diabetes a CVD risk factor.
14. idea of increased (blood) cholesterol / LDL levels / LDL to HDL ratio.
15. idea of damage to endothelium / overloading of receptors.
16. formation of atheroma / plaque /atherosclerosis } / eq.
17. idea of loss of elasticity of artery / narrowing of lumen / eq. State what is meant by the term template for the synthesis of mRNA. - Correct Answers ✅1) idea that the RNA nucleotides attach to this strand.

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2. idea of nucleotide / base sequence that directs the synthesis of complementary sequence / mRNA / eq. Differences between the processes of replication and transcription of DNA. - Correct Answers ✅Replication:
3. uses DNA nucleotides.
4. uses DNA polymerase.
5. ref. to semi conservative.
6. copies both DNA strands.
7. makes DNA double helix. Transcription:
8. uses RNA nucleotides.
9. uses RNA polymerase.
10. not semi conservative.
11. cops only 1 DNA strand.
12. makes single RNA strand.

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Explain the meaning of the term recessive allele. - Correct Answers ✅1) idea that both of these alleles need to be present in order for the recessive phenotype to be expressed.

2. different form of a gene / eq.
3. same locus /position / eq.
4. different base sequence / eq. How is temperature controlled in an investigation? - Correct Answers ✅heat shield. Explain why people with CF can have breathing difficulties. - Correct Answers ✅1) produces {thicker / stickier / more viscous / eq} mucus.
5. blocking { trachea / bronchi / bronchioles / airway / eq} / eq.
6. cilia are unable to move mucus out of lungs / eq.
7. idea of reduced flow of {air / oxygen } to alveoli.
8. idea of reduced concentration gradient for {oxygen / carbon dioxide} (in alveoli).
9. idea of loss of surface area / elasticity / eq.
10. idea of reduced gaseous exchange.
11. trapped bacteria may result in more respiratory infections / eq.

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Explain the effect of the conc. of an enzyme on the initial rate of reaction of enzyme substrate complexes. - Correct Answers ✅1) idea that enzyme lowers activation energy / provides alternative reaction pathway.

2. idea that the higher concentration of enzyme means that more active sites are available.
3. more chance of a collision between {enzyme / active site } and substrate.
4. reference to enzyme - substrate complex / specific interaction between enzyme active site and substrate.
5. idea that substrate is in excess / enzyme concentration is limiting factor.
6. as the enzyme conc. increases the ROR increases. Explain how the information in a pedigree diagram suggests a disorder/disease is due to a ... allele. - Correct Answers ✅Talk about:
7. how many people it has affected.
8. specific people and what their genotypes might be.
9. expand on point using pedigree.
10. the number of offspring with disorder/disease.
11. couples and their genotypes and what phenotypes they bring about in their children.

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Explain the ways in which the structures of amylose and glycogen make them suitable for energy storage. - Correct Answers ✅1) contain glucose / eq.

2. idea that they are compact so large {numbers of glucose / amylose / glycogen } molecules can fit into a small volume (large amounts of energy in small volume).
3. insoluble therefore does not affect osmosis / eq.
4. large molecules therefore remains in cells / too big to diffuse out or into cells / eq. Explain how rapid gas exchange takes place in a mammal. - Correct Answers ✅1) idea that large surface area provided by alveoli.
5. idea that large surface area provided by capillary network.
6. idea that concentration gradient maintained by ventilation of / air flow in / eq. the lungs.
7. idea that concentration gradient maintained by circulation / mass flow / eq. of blood.
8. idea that diffusion pathway is small because alveoli have a thin wall.
9. idea that diffusion pathway is small because capillaries have a thin wall / are in contact with alveoli / are only one cell thick / eq.
10. idea that air is warmed because lungs are in core of body.

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8. warmer air enables faster movement / diffusion / eq. of gases / eq.
9. reference to respiratory pigment / haemoglobin / red blood cells / eq. to carry oxygen. Explain how the structure of an artery is related to its function. - Correct Answers ✅1) smooth endothelium lining to reduce friction (between wall and blood) / eq.
10. thick elastic wall to allow stretch and recoil /eq.
11. collagen layer to provide strength / withstand high blood pressure / eq.
12. smooth muscle in wall to enable artery to change diameter / eq. Explain why mammals need a blood circulation system. - Correct Answers ✅1) mammals have a large volume to surface area ratio.
13. mammals have high nutrient / oxygen requirement.
14. heart and circulation provides a bulk / mass transport system.
15. that overcomes the limitations of diffusion. Suggest why BMI is used. - Correct Answers ✅1) idea that height has an impact on body mass.
16. BMI is related to both mass and height.

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Suggest why CVD is expressed as incidence per 1000. - Correct Answers ✅to allow comparison between groups of different sizes / eq. Explain what is meant by the term fluid mosaic. - Correct Answers ✅1) randomly arranged / scattered / eq. proteins in the bilayer.

2. phospholipids forming the bilayer are free to move. Explain why a triplet code is required for the synthesis of protein. - Correct Answers ✅1) only four bases.
3. need to code for 20 / more than 16 amino acids.
4. three bases is the minimum number that provides sufficient combinations to code for each amino acid. Explain how Meselson and Stahl confirmed the semiconservative mechanism of DNA replication. - Correct Answers ✅1) Meselson and Stahl's experiment was designed to distinguish between different types of replication.
5. at the start of the experiment cells were grown in a medium with heavy nitrogen / 15N.

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3. only a heavy DNA band was observed.
4. the cells were then transferred to a medium with light nitrogen / 14N.
5. after one round of replication an intermediate DNA band was observed.
6. after two rounds of replication intermediate and light bands were observed.
7. showing that replication was semiconservative / one strand of original DNA and one strand of newly synthesised DNA. Explain the meaning of the term semi-conservative replication. - Correct Answers ✅1) idea that new DNA is synthesised.
8. idea of a new DNA contains original strand and new strand. Compare and contrast exocytosis and endocytosis. - Correct Answers ✅SIMILARITIES: º both used to transport large particles / large

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quantities of material (1) º both involve (phospholipid) membrane vesicles (1) DIFFERENCE: º exocytosis is export and endocytosis is import of material (1) Compare and contrast the structures of glycogen and starch. - Correct Answers ✅SIMILARITIES: º both polysaccharides / formed from many (alpha) glucose monomers (1) º joined by glycosidic bonds (1) DIFFERENCES: º starch is composed of two polysaccharides, glycogen only one (1) º amylose is a {straight / helical} chain, amylopectin and glycogen are both branched molecules (1) State what is meant by the term gene. - Correct Answers ✅sequence of BASES of DNA that code for a polypeptide

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Explain why each codon for the DNA genetic code must contain at least three bases. - Correct Answers ✅º enough codons needed for 20 different amino acids (1) º four bases are used in the genetic code (1) º triplet code provides enough / 43 / 64 possible codons (1) The CFTR protein coded for by this mutation has one missing amino acid compared to the functioning protein. Explain how this mutation results in a non-functioning CFTR protein. - Correct Answers ✅º there will be a different sequence of R groups (1) º therefore the CFTR protein has a different tertiary structure (1) º because of different {types of / position of} bonds between the R groups (1) º therefore the movement of chloride ions through the cell membrane is affected (1)

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Explain why people with cystic fibrosis may develop lung infections. - Correct Answers ✅º produces very thick, sticky mucus (1) º because of reduced water transport from cells (1) º cilia lining airways are unable to move mucus (1) º therefore microorganisms get trapped in the mucus (1) º mucus provides suitable growth conditions for growth of microorganisms (1) Describe the roles of RNA in the synthesis of collagen. Collagen is an insoluble, fibrous protein. - Correct Answers ✅º an mRNA molecule codes for each of the polypeptide chains in collagen (1). º mRNA carries a copy of the genetic code for collagen out of the nucleus to ribosome (1).