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It is helpful to make a table to summarize adverse drug events
Typology: Cheat Sheet
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Drugs (^) Effects on other drugs Effects of other drugs on the med Therapeu4c range (mcg/mL) Carbamazepine - Inducers: gluc., 1A, 2C, 3A
- metabolized by 3A4 to ac?ve metabolite and epoxide hydrolase to epoxide (inac?ve)
- Clarithromycin: inhibitor of 3A
- Valproic acid: inhibitor epoxide hydrolase
- Phenytoin, rifampin: inducer of 3A
4 – 12
Phenytoin - Inducers: gluc., 1A, 2C, 3A
- Warfarin: substrate for 2C9, ?me dependent à ini?al inhibi?on but then induc?on
- clearance decreased by inhibi?on of 2C9/
- clearance enhanced by CBZ, rifampin.
10 – 20
Valproic acid - Inhibitors: 2C9, gluc., epoxide hydrolase
- metabolic pathway: gluc, beta- oxida?on, 2C
- Felbamate: inhibitor (gluc, beta- oxida?on)
- CBZ, PHT, PB, rifampin, lamotrigine: inducers (only gluc)
50 – 100
Lamotrigine - Inducers: gluc (weak) - Metabolic pathway: gluc (major)
- Valproic acid: inhibitor (gluc)
- CBZ, PHT, PB, rifampin: inducers