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Semester I Examinations 2009/2010: Pharmacology and Therapeutics, Exams of Pharmacology
Information about the semester i examinations for the pharmacology and therapeutics department in the academic year 2009/2010. It includes exam codes, modules, exam durations, and instructions. Various topics such as drug mechanisms, guinea pig ileum experimental preparation, noradrenergic transmission, cholinergic receptors, drug absorption and distribution, drug metabolism, and tolerance and dependence.
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Semester I Examinations 2009/ 2010
Exam Code(s) 3BS9, 3BO2, 3BY1, 3BY2, 1EM1, 1OA1, 1MSR1, 1MST1, 1NP1, 1MV Exam(s) Module Code(s) PM304, PM Module(s) Basic Pharmacology, Principles of Pharmacology Paper No. 1 Repeat Paper External Examiner(s) Prof. D. S. McQueen Prof. I. Campbell Prof. R. Docherty Internal Examiner(s) Dr. J. Kelly Ms. S. O’Brien Dr. M. Grealy *Dr. P. Welsby
Instructions: Answer 5 Questions
All questions carry equal marks. Duration (^) 3 Hours No. of Pages 1 Department(s) Pharmacology & Therapeutics Course Co-ordinator(s) Dr. P. Welsby Requirements : MCQ Release to Library: Yes No Handout Statistical/ Log Tables Cambridge Tables Graph Paper Log Graph Paper Other Materials
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PM304, PM551 Semester I 2009/ 2010
- Describe the different mechanisms by which drugs produce their effects, illustrating your answer with specific drug examples.
- Describe the guinea pig ileum experimental preparation and the means by which it can be used for elucidating drug action (50%). Characterize the different types of dose responses that can be elicited, citing five specific examples (50%).
- Describe with the aid of diagrams the sequence of events that occur in noradrenergic transmission from uptake of precursor to termination of transmitter action (50%). List three conditions that are treated by manipulation of noradrenergic transmission and detail how these treatments work, giving specific drug examples (50%).
- Write an essay on cholinergic receptors of the autonomic nervous system. Include in your answer receptor classification, location, physiological effects and examples of drugs acting at each receptor.
- Describe, with the aid of diagrams, how drugs are absorbed and distributed throughout the body after an oral dose, giving specific drug examples.
- Describe the metabolic events that occur during phase I and phase II reactions of drug metabolism. Use specific drug examples to illustrate your answer.
- Define the terms tolerance and dependence (10%). Using specific drug examples, describe the characteristics of each (90%).
- Describe the main methods of blinding and randomisation used in design of clinical trials.