CPIA Exam 2024 Version Best Studying Material with All Questions from Actual Past Exam, Exams of Laboratory Practices and Management

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This individual is appointed to the IACUC, who has direct or delegated program responsibility, and has training or experience in laboratory animal science and medicine or in the care of the species being used. a. IACUC Chair b. Chief Executive Officer (CEO) c. Institutional Official (IO) d. Attending Veterinarian (AV) ---------- Correct Answer ---------- d. Attending Veterinarian (AV) This individual is appointed to the IACUC as a knowledgeable and effective leader is crucial to an effective IACUC. a. IACUC Chair b. Chief Executive Officer (CEO) c. Institutional Official (IO) d. Attending Veterinarian (AV) ---------- Correct Answer ---------- a. IACUC Chair True/ False: The Non-Affiliated Member is appointed to the IACUC as a representative of the general community interests, and not affiliated in any way with the facility other than as a member of the Committee,and shall not be a member of the immediate family of a person who is affiliated with the facility. ---------- Correct Answer ---------- True According to USDA Regulations, an IACUC may have no more than how many members from any one administrative unit? a. 3 b. 4 c. 5 d. 6 ---------- Correct Answer ---------- a. 3 True/ False. The third Nuremberg Code states that experiments should be designed and based on animal experimentation. ---------- Correct Answer ---------- True What year did Congress pass the Laboratory Animal Welfare Act? a. 1971 b. 1963 c. 1966 d. 1979 ---------- Correct Answer ---------- c. 1966 In what year was the Animal Care Panel established? a. 1950 b. 1976

c. 1963 d. 1985 ---------- Correct Answer ---------- a. 1950 True False, in 1963 the incorporation of the American Association for the Accreditation of Laboratory Animal Care (AAALAC) was established. ---------- Correct Answer ---------- False, AAALAC was incorporated in 1965. In what year was the first edition of the Guide was developed? a. 1950 b. 1963 c. 1965 d. 1967 ---------- Correct Answer ---------- b. 1963 True/ False: The Animal Care Panel changed its name to the American Association for Laboratory Animal Science (AALAS) in 1967. ---------- Correct Answer ---------- True In what year was the first Public Health Service Policy on Humane Care and Use of Laboratory Animals? a. 1971 b. 1973 c. 1974 d. 1979 ---------- Correct Answer ---------- b. 1973 Public Responsibility in Medicine and Research (PRIM&R) was established in which year? a. 1973 b. 1974 c. 1979 d. 1982 ---------- Correct Answer ---------- a. 1973 True/False: The PHS Policy required each animal-using grantee institution to have a PHS Assurance and a committee to maintain oversight of its animal care program in

1979. ---------- Correct Answer ---------- True What year was the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research and Training promulgated? a. 1979 b. 1982 c. 1985 d. 1986 ---------- Correct Answer ---------- c. 1985 What year was the Health Research Extension Act passed by congress? a. 1979 b. 1982 c. 1985 d. 1986 ---------- Correct Answer ---------- c.

True/ False: The Animal Welfare Act Amendments passed by Congress in 1985. ---------

• Correct Answer ---------- True AAALAC became the Association for the Assessment and Accreditation of Laboratory Animal Care International in what year? a. 1990 b. 1991 c. 1996 d. 2000 ---------- Correct Answer ---------- c. 1996 According to which regulation requires a member of the IACUC to be a practicing scientist experienced in research involving animals. a. AWA b. PHS Policy c. HREA d. U.S. Government Principles ---------- Correct Answer ---------- b. PHS Policy According to the Animal Welfare Act, what is the minimum number of members for the IACUC? a. Five b. Two c. Three d. Four ---------- Correct Answer ---------- c. Three According to the PHS Policy, what is the minimum number of members for the IACUC? a. Five b. Two c. Three d. Four ---------- Correct Answer ---------- a. Five What are the required IACUC members according to the Animal Welfare Act? a. Chair, Veterinarian, Non-Scientist b. Chair, Veterinarian, Scientist c. Chair, Veterinarian, Non-Affiliated d. Veterinarian,Non-Affiliated, Non-Scientist ---------- Correct Answer ---------- c. Chair, Veterinarian, Non-Affiliated What are the required IACUC members according to the PHS Policy? a. Chair, Veterinarian, Non-Scientist, Researcher, Administrator b. Chair, Veterinarian, Scientist, Non-scientist, Non-affiliated c. Chair, Veterinarian, Non-Affiliated, CEO, IO d. Veterinarian,Non-Affiliated, Non-Scientist, CEO, IO ---------- Correct Answer ---------- b. Chair, Veterinarian, Scientist, Non-scientist, Non-affiliated

A standard or guideline that specifies in detail a method, technology, or technique for achieving a desired outcome; it does not provide for modification in the event that acceptable alternative methods are available or unusual circumstances arise. a. Principles b. Policies c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- d. Engineering Standard A standard or guideline that, while describing a desired outcome, provides flexibility in achieving this outcome by granting discretion to those responsible for managing the animal care and use program, the researcher, and the IACUC. a. Practice Standard b. Study Design c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- c. Performance Standard The application of professional judgement by qualified, experienced individuals to a task or process over time, an approach that has been demonstrated to benefit or enhance animal care and use. a. Practice Standard b. Principles c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- a. Practice Standard Commonly derived from public agencies or private entities, they are generally practical statements of collective wisdom, convention, or management direction that are internal to the entity. a. Practice Standard b.Policies c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- b. Policies Broader in their scope and intended application, they are accepted generalizations about a topic that are frequently endorsed by many and diverse organizations. a. Practice Standard b. Principles c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- b. Principles Typically detailed, they are a step-by-step process meant to ensure the consistent application of institutional practices. a. Procedures b. Policies c. Principles d. Performance Standards ---------- Correct Answer ---------- a. Procedures

True/False: A quorum is the majority of the voting members of the IACUC (>50%). ------- --- Correct Answer ---------- True These official IACUC actions require a quorum. a. Full Commmittee Review and Designated Review b. Full Committee Review of a research project and suspension of an activity. c. Designated Member Review and suspension of an activity d. Facility Inspection and Program Review ---------- Correct Answer ---------- b. Full committee review of a research project and suspension of an activity. According to the Animal Welfare Act, what is the fifth IACUC Function? a. Review/Investigate Concerns b. Make Recommendations to IO c. Reports to IO d. Be authorized to suspend an activity ---------- Correct Answer ---------- b. Make Recommendations to IO True/ False: According to the Health Research Extension Act of 1985, the Secretary, acting through the Director of NIH, establishes the guidelines for the proper care of animals to be used in biomedical and behavioral research? ---------- Correct Answer ----- ----- True Which U.S. Government Principle states that the care and use of animals should be in accordance with the Animal Welfare Act? a. U.S. Government Principle I b. U.S. Government Principle II c. U. S. Government Principle III d. U. S. Government Principle IV ---------- Correct Answer ---------- a. U.S. Government Principle I True/ False: U.S. Government Principle II states that procedures involving animals should be designed and performed with due consideration of their relevance to human or animal health, the advancement of knowledge, or the good of society? ---------- Correct Answer ---------- True Which U. S. Government Principle indicates that animal should be of minimum number required to obtain valid results? a. U.S. Government Principle I b. U.S. Government Principle II c. U. S. Government Principle III d. U. S. Government Principle IV ---------- Correct Answer ---------- c. U.S. Government Principle III True/False: The recognized methods of review in accordance to the PHS Policy and Animal Welfare Act are Full Committee Review and Expedited Review? ---------- Correct Answer ---------- False. Full Committee Review and Designated Member Review

The three Rs of Russell and Burch stand for what? a. Research, refinement, and recovery. b. Replace, recognize, and recover. c. Research, results, and review. d. Replacement, reduction, and refinement. ---------- Correct Answer ---------- d. Replacement, reduction, and refinement. True/ False: Endpoint criteria describe when it is time to submit an updated animal protocol form. ---------- Correct Answer ---------- Fals. Endpoint criteria describe when it is time to Intervene to remove an animal from a study, sometimes by euthanizing an animal. True/ False: An example of refinement is the use of a new blood collection technique that causes less pain and distress. ---------- Correct Answer ---------- True Because they cannot vomit and are not prone to aspiration pneumonia, which of the following animals should not routinely be fasted prior to surgery? a. Ferrets and cats b. Dogs and cats c. Rodents and rabbits d. Dogs, cats, and primates ---------- Correct Answer ---------- c. Rodents and rabbits True/ False: The proper sequence for a designated review by the IACUC is: Review materials sent to a quorum of voting members; a majority do not request full committee review; the Chair assigns one or more members as designated reviewers. ---------- Correct Answer ---------- False. The proper sequence for designated review by the IACUC is: Review materials are sent to all voting members; full committee review is not requested by any member; the Chairperson assigns one or more IACUC members as designated reviewers. To comply with the Animal Welfare Regulations, what is the proper course of action to follow if a significant deficiency is NOT corrected according to the plan set forth in the semi-annual evaluation report? a. Report the situation through the IO to USDA within 30 days. b. Report the situation through the IO to USDA within 15 days. c. Report the situation through the IO to USDA within 3 months. d. Report the situation through the IO to USDA within 6 months. ---------- Correct Answer ---------- b. Report the situation through the IO to USDA within 15 days. True/ False: Although opinions vary about the details needed in IACUC minutes, a typical standard is that IACUC minutes should provide as little information as possible to prevent outside observers from understanding how the IACUC operates. ---------- Correct Answer ---------- False. the IACUC minutes should allow an outside observer to verify that deliberations occurred, and understand the outcomes of those deliberations.

Which of these IACUC protocol review outcomes are recognized in the Animal Welfare Regulations and PHS Policy? a. Approve, disapprove, and probationary approval. b. Approve, conditional approval, and approval pending modifications. c. Approve, require modifications (to secure approval), and deferred approval. d. Approve, require modifications (to secure approval), and withhold approval. ---------- Correct Answer ---------- d. Approve, require modifications (to secure approval), and withhold approval. Which of the following statements is TRUE regarding review outcomes in FCR versus DMR of animal protocols? a. The "withhold approval" option is available in FCR, but not DMR. b. Requiring modifications before approval is available in FCR but not in DMR. c. The "approval" option is available in FCR, but not DMR. d. Requiring modifications before approval is available in DMR but not in FCR. ---------- Correct Answer ---------- a. The "withhold approval" option is available in FCR, but not DMR. According to the PHS Policy and the AWRs what is required for the institutions to keep in the IACUC meeting minutes? a.Attendance Records, Committee Activities, Committee Deliberations b. Meeting Date, Attendance Records, Committee Deliberations c. Full Committee Review and Designated Review d. Approve, Modifications required (to secure approval), or Withhold Approval ---------- Correct Answer ---------- a.Attendance Records, Committee Activities, Committee Deliberations True/ False: Animal applications and proposed significant changes, in accordance with the PHS Policy and AWRs,should be retained for the duration of the animal activity and an additional two years after the end of the activity. ---------- Correct Answer ---------- False. For the duration of the animal activity and an additional three years after the end of the activity. According to the PHS Policy and the AWRs, how long should the Semiannual IACUC reports and recommendations be retained by the institution? a. Three months b. Three Years c. Five months d. Five Years ---------- Correct Answer ---------- b. Three years In order to qualify for support from the PHS for activities involving animals, what must institutions provide? a. A Memorandum of Understanding b. An Agreement c. An Assurance of Compliance with the PHS Policy

d. A Standard Operating Procedure ---------- Correct Answer ---------- c. An Assurance of Compliance with the PHS Policy True/ False: Institutions containing species of animals covered by the AWRs must be registered with AAALAC? ---------- Correct Answer ---------- False. Must be registered with the Animal Care division of the Animal Plant Health Inspection Service (APHIS). How often is the USDA registration renewed? a. Annually b. Every Three Years c. Semi-Annually d. Every Five Years ---------- Correct Answer ---------- b. Every Three Years When should an institution notify the AC Director with changes to the institution's name, address, ownership, or operations affecting its status as a research facility? ---------- Correct Answer ---------- Within 10 days of the change How often should a PHS Assured institution report to OLAW through the IO? ---------- Correct Answer ---------- Annually When should the USDA registered institution report to APHIS/AC Regional Director? ---- ------ Correct Answer ---------- Annually, on or before December 1st. What circumstances require the IACUC of a PHS Assured institution to report through the IO to OLAW? ---------- Correct Answer ---------- Any serious reoccurring noncompliance with the PHS Policy, any serious deviation from the Guide, and any suspension of any activity by the IACUC. What two circumstances allow for the semiannual reports to be submitted to OLAW? ---- ------ Correct Answer ---------- If an institution is not accredited by AAALAC, or upon request by OLAW or other PHS representative. According to federal law, what are types of proprietary information? ---------- Correct Answer ---------- Copyrights, patents, trademarks, and trade secrets Under federal law, what protection can be attached to "original works of authorship fixed in any tangible medium of expression?" ---------- Correct Answer ---------- Copyright What can be obtained for a "new and useful process, machine, manufacture, or composition of a matter, or any new and useful improvement?" ---------- Correct Answer ---------- Patent This is something that distinguishes the goods or services of the owner from those of others. ---------- Correct Answer ---------- Trademark

This is information that has economic value by virtue of its not being generally known to or readily ascertainable by the public. ---------- Correct Answer ---------- Trade Secret This may be defined by federal or state law or by private agreements or policies. ---------

• Correct Answer ---------- Confidential information True/ False, the animal care and use program includes animal and veterinary care, policies and procedures, personnel and program management and oversight, occupational health and safety, IACUC functions, and animal facility design and management. ---------- Correct Answer ---------- True The primary oversight responsibilities in the Program rest with who? ---------- Correct Answer ---------- Institutional Official (IO), Attending Veterinarian (AV), and the IACUC What must inter-institutional collaboration have to eliminate potential ambiguities about responsibility for animal care and use? a. A formal written understanding, such as a contract, memorandum or understanding, or agreement. b. A USDA registration c. AAALAC Accreditation d. Policies and Procedures ---------- Correct Answer ---------- a. A formal written understanding, such as a contract, memorandum of understanding, or agreement. What must the inter-institutional collaboration's formal written understanding address? a. The PHS Policy b. The responsibility for offsite animal care and use, animal ownership, and IACUC review oversight. c. The Disaster Plan d. The Occupational Health and Safety Program ---------- Correct Answer ---------- b. The responsibility for offsite animal care and use, animal ownership, and IACUC review and oversight. True/ False. According to the Guide, what is the IACUC responsible for being the police of the animal care and use program. ---------- Correct Answer ---------- False. According to the Guide, the IACUC is responsible for the oversight and evaluation of the entire Program and its components. According to the AWRs what are animal study areas? a. Areas where survival surgery occur b. Areas where animals are housed outside of core for greater than 12 hours. c. Areas where animals are housed outside of core for greater than 24 hours. d. Areas where nonsurvival procedures occur. ---------- Correct Answer ---------- b. Areas where animals are housed outside of core for greater than 12 hours According to the PHS Policy, what are satellite facilities? a. Areas where survival surgery occur

b. Areas where animals are housed outside of core for greater than 12 hours. c. Areas where animals are housed outside of core for greater than 24 hours. d. Areas where nonsurvival procedures occur. ---------- Correct Answer ---------- c. Areas where animals are housed outside of core for greater than 24 hours What is the minimum number of members needed to form a subcommittee for facility inspection? a. Quorum b. Three c. Five d.Two ---------- Correct Answer ---------- d. Two, no member should be excluded, if they wish to participate. Who is responsible for providing the resources to support personnel training? a. Institution b. IACUC c. Animal Facility d.AttendingVeterinarian ---------- Correct Answer ---------- a. The Institution, the IACUC is responsible for providing oversight and evaluating the effectiveness of the training program. All program personnel training should be documented True/ False: Each institution should establish and maintain an occupational health and safety program (OHSP) as an essential part of the overall Program of animal care and use. ---------- Correct Answer ---------- False. Each institution MUST establish and maintain an OHSP as an essential part of the overall Program of Animal Care and Use. True/ False: Animals that cannot be relocated or protected from the consequences of the disaster must be humanely euthanized. ---------- Correct Answer ---------- True True/False: Contingency plans should address more than natural disasters, they should also address security risks. ---------- Correct Answer ---------- True. Criminal activities such as personnel harassment and assault, facility trespassing, arson, and vandalism pose to laboratory animals, research personnel, equipment and facilities, and biomedical research at the institution threaten the security of the program. What regulations require the institution to verify, before the award, that the IACUC has reviewed and approved the components of the grant applications related to the care and use of lab animals. a. AWARs b. PHS Policy c. U.S.Government Principles d. PHS Policy and NIH Grants Policy Statement ---------- Correct Answer ---------- d. PHS Policy and NIH Grants Policy Statement (Chapter 4.1.1.2.) Which of the following offers a voluntary accreditation program of institutional animal care and use programs?

a. PHS b. USDA c. OLA d. AAALAC ---------- Correct Answer ---------- d. AAALAC Which of the following is a required member of the IACUC? a. Institutional Official b. Laboratory Animal Technician c. Individual not Otherwise Affiliated with the Institution d. Representative from a Local Animal Advocacy Organization ---------- Correct Answer - --------- c. Individual not Otherwise Affiliated with the Institution True/False: OPRR Division of Animal Welfare was separated from OPRR and became the Office of Laboratory Animal Welfare (OLAW), NIH in 2002. ---------- Correct Answer - --------- False. The OPRR Division of Animal Welfare became the Office of Laboratory Animal Welfare (OLAW) in 2000 True/ False: There are 10 U.S.Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. ---------- Correct Answer -- -------- False. There are 9 U.S. Government Principles True/ False: Risk/ Benefit Analysis is for research that involves more than minimal risk of harm to the subjects, the investigator must assure that the amount of benefit clearly outweighs the amount of risk. Only if there is a favorable risk - benefit ratio may a study be considered ethical. ---------- Correct Answer ---------- True What agency is responsible for overseeing the Animal Welfare Act? a. PHS Policy b. OLAW c. AAALAC d. USDA ---------- Correct Answer ---------- d. USDA What agency is responsible for overseeing the PHS Policy? a. AWA b. OLAW c. AAALAC d. USDA ---------- Correct Answer ---------- b. OLAW Which agency is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs? a. DoD b. OLAW c. AAALAC d. USDA ---------- Correct Answer ---------- c. AAALAC

Which agency is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices; and by ensuring the safety of our nation's food supply, cosmetics, and products that emit radiation. a. DoD b. FDA c. OLAW d. USDA ---------- Correct Answer ---------- b. FDA What is the official VA animal protocol form called? a. Chief Research and Development Office(CRADO) b. Chief Veterinary Medical Officer (CVMO) c. Animal Component of Research Protocol (ACORP) d. Department of Defense (DoD) ---------- Correct Answer ---------- c. Animal Component of Research Protocol (ACORP) True/ False: The VA Central Office given the authority and the responsibility for managing all human,animal, and laboratory VA research activities is the Chief Research and Development Office (CRADO). ---------- Correct Answer ---------- True Who is the VA Central Office veterinarian, who is given the primary responsibility for formulating VA animal research policy, advising senior VA administrators on animal research issues, and providing support and guidance as needed to field research personnel conducting animal research? a. Chief Research and Development Office(CRADO) b. Chief Veterinary Medical Officer (CVMO) c. Animal Component of Research Protocol (ACORP) d. Department of Defense (DoD) ---------- Correct Answer ---------- b. Chief Veterinary Medical Officer (CVMO). What is the term used by scientists to describe many different processes that involve making duplicates of biological material? a. Cloning b. Somatic Cell Nuclear Transfer c. Stem Cells d. ES Cells ---------- Correct Answer ---------- a. Cloning The cloning technique that led to the cloning of Dolly the sheep in 1997, which resulted in an animal that was a genetic twin -- although delayed in time -- of an adult sheep. a. Cloning b. Somatic Cell Nuclear Transfer c. Stem Cells d. ES Cells ---------- Correct Answer ---------- b. Somatic Cell Nuclear Transfer What are unique and essential cells found in animals that are capable of continually reproducing themselves and renewing tissue throughout an individual organism's life?

a. Cloning b. Somatic Cell Nuclear Transfer c. Stem Cells d. ES Cells ---------- Correct Answer ---------- c. Stem cells What are the most versatile of all stem cells because they are less differentiated, or committed, to a particular function than adult stem cells. These cells have offered hope of new cures to debilitating and even fatal illness? a. Cloning b. Somatic Cell Nuclear Transfer c. Stem Cells d. ES Cells ---------- Correct Answer ---------- d. ES cells .What is an organism whose genome has been altered by the techniques of genetic engineering so that its DNA contains one or more genes not normally found there. a. Cloning b. Genetically Modified Organism (GMO) c. Stem Cells d. Xenotransplantation ---------- Correct Answer ---------- b. Genetically Modified Organism (GMO) Any scientific technique or method should only be used when it is appropriate to what the researcher hopes to discover. a. Risk/ Benefit Analysis b. Study Design c. Performance Standards d. Engineering Standards ---------- Correct Answer ---------- b. Study Design The process of grafting or transplanting organs or tissues between members of different species. a. Cloning b. Genetically Modified Organism (GMO) c. Stem Cells d. Xenotransplantation ---------- Correct Answer ---------- d. Xenotransplantation True/ False: The Institutional Official (IO) is individual is the highest operating official of the organization, and is responsible for appointing the IACUC. May delegate authority to appoint the IACUC if the delegation is specific and in writing. ---------- Correct Answer --- ------- False. The Chief Executive Officer (CEO) is the highest operating official and responsible for appointing the IACUC, but may specifically delegate in writing. True/ False: The Attending Veterinarian (AV) is who the IACUC reports to, and has administrative and operational authority to commit institutional resources to ensure compliance with the PHS Policy and other requirements. ---------- Correct Answer -------- -- False. The Institutional Official (IO) is who the IACUC reports to, and has

administrative and operational authority to commit institutional resources to ensure compliance with the PHS Policy and other requirements. Which of the following does not need to be maintained by the IACUC? a. Copy of Assurance b. Semiannual Reports c. Logs of Laboratory Records d. Minutes from IACUC meetings ---------- Correct Answer ---------- c. Logs of Laboratory Records The IACUC may suspend an activity only after: a. a vote of a majority of the quorum present at a convened meeting. b. a discussion with the Principal Investigator takes place. c. the Institutional Official has be notified in writing of the event. d. all fact finding of the event has been conducted and documented. ---------- Correct Answer ---------- a. a vote of a majority of the quorum present at a convened meeting. Training and instruction of personnel must include guidance in which of the following areas? a. Effective writing of animal use proposals b. Proper use of personal protective equipment c. Appropriate communication with animal activist groups d. Research or testing methods that limit the use of animals ---------- Correct Answer ---- ------ d. Research or testing methods that limit the use of animals True/ False: The Microenviorment is the physical environment of the secondary enclosure, such as the room, a barn or an outdoor habitat. ---------- Correct Answer ------ ---- False. The Macroenvironment is the physical environment of the secondary enclosure, such as the room. An example of the microenvironment is: a. Cage b. Room c. Outdoor habitat d. Barn ---------- Correct Answer ---------- a. Cage True/ False: Exposure to wide temperature and humidity fluctuations or extremes may result in behavioral, physiologic, and morphologic changes, which might negatively affect animal well-being and research performance, as well as, outcomes of research protocols. ---------- Correct Answer ---------- True The acceptable relative humidity range for must mammalian species is between: a. 30-70% b. 40-80% c. 20-60% d. 50-90% ---------- Correct Answer ---------- a. 30-70%

What could be the cause for high intracage ammonia concentration in rodent isolator cages? a. Elevated microenvironmental relative humidity b. Inadequate resources for thermoregulation c. Exposure to wide temperature and humidity fluctuations d. The use of recycled air to ventilate animal rooms ---------- Correct Answer ---------- a. Elevated microenvironmental relative humidity What is the acceptable guideline for fresh air changes per hour in animal housing rooms to maintain macroenvironmental air quality? a. 5- 10 b. 10- 15 c. 15- 20 d. 20- 25 ---------- Correct Answer ---------- b. 10- 15 True/ False: Single housing of social species should be the default, and no justification is needed. ---------- Correct Answer ---------- False. Single housing of social species should be the exception and justified based on experimental requirements or veterinary- related concerns about animal well-being. True/ False: The animal cage cards should include the following: Source, Strain/ Stock, PI Name/Contact Information, Pertinent Dates, and Protocol Number. ---------- Correct Answer ---------- True True/ False: The composition of the water quality is essential to aquatic animal well- being. ---------- Correct Answer ---------- True True/ False: The three general categories of life support systems for aquatic animals are:Recirculating Systems, Flow Through Systems, and Static Systems. ---------- Correct Answer ---------- True True/ False: The Attending Veterinarian is responsible for providing guidance to investigators and personnel involved in the care and use of animals to ensure appropriate husbandry, handling, medical treatment, immobilization, sedation, analgesia, anesthesia, and euthanasia. ---------- Correct Answer ---------- True True/ False: The Principal Investigator is responsible for providing guidance and oversight to surgery program and perioperative care involving animals. ---------- Correct Answer ---------- False. The Attending Veterinarian is responsible for providing guidance and oversight to the surgery program. Animals must be acquired from: a. Pet Stores b. Shelters and Pounds c. Stray animals from the street

d. Vendors evaluated for the quality of animals they supply ---------- Correct Answer ------ ---- d. Vendors evaluated for the quality of animals they supply. What should the facilities provide for the safe and secure transfer of animals at an institution: a. appropriate shipping containers b. serum samples c. appropriate loading and unloading facilities d. personal vehicle ---------- Correct Answer ---------- c. appropriate loading and unloading facilities True/ False: Animal Biosecurity includes all measures to control known or unknown infection in laboratory animals. ---------- Correct Answer ---------- True What is an essential component of comprehensive veterinary medical care and biosecurity programs: a. Animal Transport b. Animal Acqusision c. Disease Prevention (Preventive Medicine) d. Quaranite ---------- Correct Answer ---------- c. Disease Prevention (Preventive Medicine) True/ False: Aseptic technique is used to reduce microbial contamination to the lowest possible practical level. ---------- Correct Answer ---------- True Which of the following statements is true if an investigator wants to use a human clinical area for animal research? a. signs must be posted for 14 days prior to use b. Permission should be obtained from IACUC and clinical administrators. c. Signs must be posted for the duration of the procedure d. sanitizing the area after use can be left to the night housekeeping crew. ---------- Correct Answer ---------- b. Permission should be obtained from IACUC and clinical administrators. True/ False: The Principal Investigator is responsible for ensuring that the study is performed in accordance with the IACUC approved protocol. ---------- Correct Answer --- ------- True According to the Aninal Welfare Regulations, prior to IACUC review of a protocol with procedures that cause more than momentary pain or distress requires: a. IACUC Chair to be a consultant on project b. Veterinary Consult c. Requires institution to be AAALAC Accredited d. Consult with IACUC Chair ---------- Correct Answer ---------- b. Veterinary Consult Before making significant changes to the IACUC protocol, the PI must:

a. Obtain approval from animal care staff b. Modify protocol, and get a colleague to review it c. Obtain IACUC approval d. Modify protocol to keep in files ---------- Correct Answer ---------- c. Obtain IACUC Approval True/ False: Exterior windows with a nice view is required for all animal rooms as a measure of environmental enrichment. ---------- Correct Answer ---------- False. Exterior windows in an animal facility, creates a potential security risk, and creates problems with temperature and lighting control. Windows can provide environmental enrichment for some species, such as nonhuman primates. What is an example of an appropriate storage area for bedding and food: a. Dirty Side of Cagewash Room b. Corridors c. A Separate Area Free from Vermin and Toxic or Hazardous Substances. d. Surgical Suite ---------- Correct Answer ---------- c. A separate area free from vermin and toxic or hazardous substances. According to the VA handbook prior to protocol review: a. Each IACUC member is provided a list of the protocols. b. Each IACUC member is provided the lay summary of the protocols. c. A quorum of the IACUC receives the complete copies of the protocols. d. All IACUC members receive complete copies of the protocols to determine to request for FCR. ---------- Correct Answer ---------- d. All IACUC members receive complete copies of the protocols to determine to request for FCR. According to the VA handbook, all research protocols involving animals must be approved by: a. The IACUC b. The R&D Committee c. The IO d. The IACUC and then by the R&D Committee ---------- Correct Answer ---------- d. The IACUC and then by the R&D Committee True/ False: According to the USDA and PHS, the IACUC shall notify investigators and the institution in writing of its decision to approve or withhold approval. ---------- Correct Answer ---------- True According to the VA handbook, the Principal Investigator must receive notification from who before initiating the research. a. the IACUC b. The R&D Committee c. the CVMO d. ACOS ---------- Correct Answer ---------- d. ACOS

According to the Ag Guide, what are the minimum number of IACUC members: a. 2 b. 3 c. 4 d. 5 ---------- Correct Answer ---------- d. 5 According to the Ag Guide, what are the requirements for the veterinarian IACUC member: a. Training and experience in lab animal medicine b. Not affiliated with the institution c. qualified in ag animal medicine and licensed or eligible to be licensed to practice veterinary medicine. d. Practicing Scientist ---------- Correct Answer ---------- c. qualified in agricultural animal medicine and licensed or eligible to be licensed to practice veterinary medicine. According to the DoD what are the IACUC membership components: a. Veterinarian with program authority and experience in lab animal med, Nonaffiliated, and Nonscientist, 5. b. Chair, Veterinarian, Nonaffiliated, 3 c. Veterinarian, Nonaffiliated, Scientist, Nonscientist, 4 d. Chair, Veterinarian with ag experience, nonaffilliated, 3. ---------- Correct Answer ------ ---- a. Veterinarian with program authority and experience in lab animal med, Nonaffiliated, and Nonscientist, 5. What regulations require the Justification for animals, species, and numbers: a. US Government Principle III, PHS Policy D.1, AWR 2.31(e) b. US Government Principle II, PHS Policy C. 2., AWR 2.31 (c) c. US Government Principle I, PHS Policy A.2., AWR 2.31 (a) d. US Government Principle IV, PHS Policy E.1., AWR 2.36 (a) ---------- Correct Answer ---------- a. US Government Principle III, PHS Policy D.1, AWR 2.31(e) What regulations require a complete deception of proposed use of animals? a. US Government Principles, PHS Policy b. VA Handbook, AWR c. PHS Policy, AWR d. US Government Princples, PHS Policy, AWR ---------- Correct Answer ---------- c. PHS Policy, AWR Which of the following are true regarding a statistical analysis to justify animal numbers: a. Statistical analysis should be used when possible b. statistical analysis is not appropriate because IACUC can't evaluate the results. c. Statistical analysis must be performed for every protocol. d. Statistical analysis is rarely used for justifying group sizes, as it only gives estimates. ---------- Correct Answer ---------- a. Statistical analysis should be used when possible When must personnel receive training to perform animal procedures:

a. before any procedure is performed, unless waived by supervisor b. at the end of the experiment c. before any procedures are performed d. before any procedure is performed, unless have a doctoral or medical degree. ---------

• Correct Answer ---------- c. before any procedures are performed True/ False: Prolonged restraint of animals can be justified as a convenience for the research staff. ---------- Correct Answer ---------- False. Restraint devices should not be used simply as a convenience in handling or managing animals. True/ False: According to the Animal Welfare Regulations, unnecessary duplication of animal experiments is not allowed. ---------- Correct Answer ---------- True According to the AVMA Guidelines for Euthanasia, amphibians and fish can be euthanized by: a. There is no specific method, as IACUCs do not oversee cold-blooded species. b. Rapid maceration c. overdose of buffered tricaine methane sulfonate or injected barbiturates d. This is not addressed by the AVMA Guideline for euthanasia. ---------- Correct Answer ---------- c. overdose of buffered tricaine methane sulfonate or injected barbiturates True/ False: The IACUC can exempt a primate from the psychological enrichment program mandated by the Animal Welfare Act Regulations for scientific reasons, if documented in the approved protocol. ---------- Correct Answer ---------- True A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time? a. 3% b. 4% c. 1% d. 2% ---------- Correct Answer ---------- c. 1% True/ False: AWIC can be a resource for the requirement for the search in the area of alternatives. ---------- Correct Answer ---------- True A complex experience that typically results from stimuli that damage or have potential to damage tissue is: a. Pain b. Distress c. Experimental Endpoint d. Humane Endpoint ---------- Correct Answer ---------- a. Pain An aversive state in which an animal fails to cope or adjust to various stressors with which it is presented: a. Pain b. Distress

c. Experimental Endpoint d. Humane Endpoint ---------- Correct Answer ---------- b. Distress A complete loss of sensitivity to pain: a. Analgesia b. Anesthesia c. Sedation d. Tranquilization ---------- Correct Answer ---------- A. Analgesia A total loss of sensation in a part or in the entire body: a. Analgesia b. Anesthesia c. Sedation d. Tranquilization ---------- Correct Answer ---------- b. Anesthesia A state characterized by decreased awareness of surroundings, relaxation, and sleepiness: a. Analgesia b. Anesthesia c. Sedation d. Tranquilization ---------- Correct Answer ---------- c. Sedation A state of mental calming, decreased response to environmental stimuli, and muscle relaxation: a. Analgesia b. Anesthesia c. Sedation d. Tranquilization ---------- Correct Answer ---------- d. Tranquilization True/ False: Farm animals used for improving animal nutrition, breeding, management, production efficiency, or the quality of food and fiber are specifically excluded from the definition of "animal" in the AWA. ---------- Correct Answer ---------- True True/False: USDA-APHIS decided to regulate farm animals used in research in 1991, and adopted the Ag Guide and the Guide as Guidance Documents. ---------- Correct Answer ---------- True True/ False, The three factors evaluated in protocols that involve the use of food or fluid regulation are: necessary level of regulation, potential adverse consequences, methods for assessing animal well being. ---------- Correct Answer ---------- True How often should body weights be recorded for animals requiring food or fluid restriction: a. Weekly b. Twice a Week c. Monthly

d. Daily ---------- Correct Answer ---------- a. Weekly