Drugs acting on peripheral nervous system, Exams of Pharmacology

Download Drugs acting on peripheral nervous system and more Exams Pharmacology in PDF only on Docsity! The Future Pharmacist isit our website:-| www.thefuturepharmacist.com For more information follow us o Instagram, YouTube, elegram and Twitte Scanned with CamScanner Drugs Acting on Peripheral (Somatic) Nervous System 23.1 23.2 23.3 CHOOSE THE MOST APPROPRIATE RESPONSE Which of the following drugs is a nondepolarizing neuromuscular blocker: A. Succinylcholine B. Vecuronium C. Decamethonium D. Dantrolene sodium (p. 309, 314) The site of action of d-tubocurarine is: A. Spinal internuncial neurone B. Motor nerve ending C. Muscle end-plate D. Sodium channels in the muscle fibre (p. 310) At the muscle end-plate, d-tubocurarine reduces the: A. Number of Nat channels B. Duration for which the Na* channels remain open C. Ion conductance of the open Na* channel D. Frequency of Na* channel opening (p. 310) 23.1B 23.2C 23.3D | Scanned with CamScanner 23.13 23.14 23.15 23.16 23.17 Peripheral Nervous System 151 Succinylcholine is the preferred muscle relaxant for tracheal intubation because: A. It produces rapid and complete paralysis of respiratory muscles with quick recovery It does not alter heart rate or blood pressure It does not cause histamine release It does not produce postoperative muscle soreness (p. 313-314) Which of the following is applicable to mivacurium: A. It undergoes Hoffmann elimination B. It is the shortest acting nondepolarizing neuromuscular blocker C. It is excreted unchanged by kidney D. It does not cause histamine release (p. 313, 314) Neostigmine reverses the following actions of d-tubocurarine except: A. Motor weakness B. Ganglionic blockade C. Histamine release D. Respiratory paralysis (p. 315) pow Postoperative muscle soreness may be a side effect of the following neuromuscular blocker: A. d-tubocurarine B. Succinylcholine C. Pancuronium D. Atracurium (p. 313-314) The following antibiotic accentuates the nuromuscular blockade produced by pancuronium: A. Streptomycin B. Erythromycin C. Penicillin G D. Chloramphenicol (p. 315) | 23.13A 23.14B 23,15C 23.16B 23.17A Scanned with CamScanner 152 MCQs in Pharmacology 23.18 23.19 23.20 23.21 23.22 Dantrolene sodium reduces skeletal muscle tone by: A. Reducing acetylcholine release from motor nerve endings B. Suppressing spinal polysynaptic reflexes C. Inhibiting the generation of muscle action potential D. Reducing Ca?* release from sarcoplasmic reticulum in the muscle fibre (p. 316) Which of the following is a centrally acting skeletal muscle relaxant: A. Carisoprodol B. Dantrolene sodium C. Quinine D. Decamethonium (p. 317) Select the muscle relaxant that is used to contro! spasticity associated with upper motor neurone paralysis: A. Vecuronium B. Succinylcholine C. Chlorzoxazone D. Baclofen (p. 317, 318) The GABAg receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP (p. 317) The following is a skeletal muscle relaxant that acts as a central oz adrenergic agonist: A. Tizanidine B. Brimonidine C. Chlormezanone D. Quinine (p. 318) 23.18D 23.19A 23.20D 23.21C 23.22A Scanned with CamScanner 23.23 23.24 23.25 241 Peripheral Nervous System 153 Which of the following is not true of tizanidine: A. It is a clonidine congener used in spasticity due to stroke or spinal injury B. It reduces muscle tone by activating GABA, receptors C. It inhibits release of excitatory amino-acids in spinal interneurones D. It reduces muscle spasms without produ- cing weakness (p. 318) Diazepam is used as a muscle relaxant for: A. Deep intra-abdominal operation B. Tracheal intubation C. Tetanus D. Diagnosis of myasthenia gravis (p. 317) Indications of centrally acting muscle relaxants include ail of the following except: A. Balanced anaesthesia B. Traumatic muscle spasms C. Torticollis D. Electroconvulsive therapy (p. 318-319) The clinically used local anaesthetics have the follow- ing common features except: A. They are amphiphilic weak bases B. They are used for surgery in non-cooperative patients C. In their use, care of vital functions is gene- rally not needed D. They are safer than general anaesthetics in patients with respiratory and cardiovascular disease (p. 320) 23.23B 23.24C 23.25A 24.1B Scanned with CamScanner 24.6 24.7 24.8 24.9 Peripheral Nervous System 155 A resting nerve is relatively resistant to blockade by lignocaine compared to one which is repeatedly stimulated because: A. Lignocaine penetrates resting nerve memb- rane poorly B. Lignocaine binds more avidly to the inactiva- ted Na* channel C. Nerveimpulse promotes ionization of lignocaine D. Nodes of Ranvier are inaccessible in the resting state (p. 321-322) Which of the following is not the reason for greater susceptibility of smaller sensory fibres to blockade by local anaesthetics than larger motor fibres: A. Sensory fibres are inherently more sensitive than motor fibres B. More slender fibres have shorter internodal distances C. Small sensory fibres generate higher frequency longer lasting action potential D. Smaller fibres have shorter critical lengths for blockade (p. 3283) Which sensation is blocked first by low concentra- tions of a local anaesthetic: A. Pain B. Temperature C. Touch D. Deep pressure (p. 323) Injection of adrenaline along with a local anaesthetic serves the following purpose: A. Lowers the concentration of the local anaes- thetic to produce nerve block Prolongs the duration of local anaesthesia Increases the anaesthetised area Reduces the local toxicity of the local anaes- thetic (p. 323) 24.6B 24.7A 24.8A 24.9B poe Scanned with CamScanner 156 MCQs in Pharmacology 24.10 24.11 24.12 24.13 24.14 Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: Prolongs the duration of local anaesthesia Makes the injection less painful Provides a more bloodless field for surgery Reduces systemic toxicity of the local anaes- thetic (p. 323) The following local anaesthetic raises BP instead of tending to cause a fall: A. Cocaine B. Dibucaine C. Lignocaine D. Procaine (p. 324) Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue (p. 324) CORP The local anaesthetic with the longest duration of action is: A. Procaine B. Chloroprocaine C. Lignocaine D. Dibucaine (p. 325, 326) Which of the following is a poor surface anaesthetic: A. Procaine B. Lignocaine C. Tetracaine D. Benoxinate (p. 325) 24.10B 24.11A 24.12C 24.13D 24.14A Scanned with CamScanner 24,15 24.16 24.17 24.18 Peripheral Nervous System 157 The local anaesthetic having high cardiotoxic and arrhythmogenic potential is: A. B. G D. Lignocaine Procaine Bupivacaine Ropivacaine (p. 326) Which of the following statements is true for lignocaine: A. B. Cc. D. It is an ester-linked local anaesthetic It is not likely to exhibit cross-sensitivity with procaine It has a shorter duration of action than procaine It is not a surface anaesthetic (p. 325) Low concentration of bupivacaine is preferred for spinal / epidural obstetric analgesia because: A. B. Cc. D. It has a longer duration of action It can produce sensory blockade without paralysing abdominal muscles It distributes more in maternal tissues so that less reaches the foetus All of the above are correct (p. 326) The following local anaesthetic is poorly water soluble, PABA derivative and primarily used for anorectal lesions, wounds and ulcers: As B. Cc. D. Benzocaine Dibucaine Procaine Benoxinate (p. 326) 24.15C 24.16B 24.17D 24.18A Scanned with CamScanner 160 MCQs in Pharmacology 24.29 Epidural anaesthesia differs from spinal anaesthesia in that: A. Epidural anaesthesia produces less cardio- vascular complications B. Headache is more common after epidural anaesthesia C. Blood concentrations of the local anaesthetic are lower after epidural anaesthesia D. Greater separation between sensory and motor blockade can be obtained with epidu- ral anaesthesia (p. 329) 24.30 Intravenous regional anaesthesia is suitable for: A. Orthopedic manipulations on the upper limb B. Vascular surgery on the lower limb C. Head and neck surgery D. Caesarian section (p. 329-330) 24.29D 24.30A Scanned with CamScanner The Future Pharmaeist | ____ Visit our website:-| www.thefuturepharmacist.com For more information follow us o nstagram, YouTube, elegram and Twitte