Heme Immunotherapy and antineoplastics Exam 2023
with complete solution
What are two situations in which it would be advantageous to temporarily suppress
inflammatory responses? - Answer<>Transplantation, treatment of autoimmune
disease
What are two situations in which it would be advantageous to enhance immune
responses? - Answer<>Prevention/treatment of infectious diseases and cancer
what type of immunization is Vaccination considered (active vs passive)? What type
of response is elicited preferably? - Answer<>Active immunization
Humoral response (antibody production from B/plasma cells)- this is preferably to
cell-mediated immunity
what two bacteria are targeted in Caries Vaccines? How do they prevent the
bacterial disease process? Is there a commercially available vaccine for caries? -
Answer<>Streptococcus mutans and Streptococcus subrinus
prevent adherence of bacteria via generation of secretory IgA antibodies and
targeting isolated antigens needed by bacteria in plaque formation
there is no commercially active vaccine available
what are two given categories of immunostimulants? How do they work? -
Answer<>1. Thymic extracts such as Thymosin and Thymostimulin
-induce T-cell maturation
-especially effective in patients with absence of thymus (DiGeorge Syndrome)
2. Levamisole (ergamisol)
-antihelminthic agent
-thymomimetic effects; affects multiple cell populations as well (PMNs, MQs, etc.)
-show to be effective for recurrent aphthous ulcers and herpes labialis
What type of immunity is generated in antibody therapy (active vs passive) vs a
vaccine? How is this immunity different? - Answer<>Antibody therapy is PASSIVE
immunization, vs vaccines which are ACTIVE
passive immunization provides antibodies but does not induce autonomous
generation of them; therefore antibody therapies are subjected to half-lives
what are two main uses for polyclonal antibodies (what can they treat)? -
Answer<>1. PASSIVE IMMUNITY for diseases in which there is a deficiency in
humoral immunity (such as multiple myeloma)- provides rapid (but short lasting)
immunity
2. ANTITOXIN/ANTIVENIN to bind to and neutralize toxic compounds such as
rattlesnake venom, diptheria toxin, etc.
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