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solutions graded A+ 2024
- Target HBPM goal for treatment is:: <135/
- Target HBPM goal for treatment in high risk patients is:: <130/
- Above 115/75, for each increase of 20mmHg in SBP or 10mmHg in DBP, the risk of major CV and stroke events:: doubles
- in 3 adults >18yrs have HTN.: 1
- What percent of patients with HTN are under control?: 52.5%
- What two populations have the worse BP control?: -Black males -Hispanic males
- Why are black males more at risk for uncontrolled HTN?: -enhanced renal sodium absorption -3-5x more likely to whites to have stroke and kidney disease
- Prevalence of HTN:: -higher in men until age 45 years -similar rate men and women 45-65 years -higher in women after 65 years
- Is DBP or SBP more important CV risk factor until age 50.: -DBP
- SBP or DBP is more important after age 50.: SBP
- BP in Europeans:: -stroke risk assessed by both SBP and DBP until 62 years
solutions graded A+ 2024
- Nocturnal BP dips how much at night:: 15%
- Non dipper has what higher risk?: CVD and renal disease
- What is the most common problem in primary care?: hypertension
- Risk of HF in women with HTN:: increased 3x
- HTN present in majority of:: -MI -1st strokes -CHF -PAD
- Modifiable risk factors for HTN:: -obesity -metabolic syndrome -high dietary intake of fat -excessive sodium intake -physical inactivity -excessive alcohol intake -tobacco use
- Non-modifiable risk factors for HTN:: -AA -advancing age -family history
solutions graded A+ 2024
-daytime avg >140/ -nighttime avg >125/
- checking for orthostasis:: -have patient stand for one full minute before taking BP
- Target organ damage to the brain:: -CVA -encephalopathy -dementia -multi-infarct -early cognitive decline
- Target organ damage to the eye:: -can damage retina -hard exudates -flame hemorrhage -cotton wool spots
- Target organ damage to the heart:: -LVH -CAD -MI -Rhythm disorders -aortic and PAD
solutions graded A+ 2024
-AAA
- what drug is most effective for decreasing LVH?: ACEI
- LVH is a risk factor for:: -stroke -CAD -PAD -HF
- target organ damage to the kidney:: -CKD -GFR <
- What is the new target organ to assess:: -erectile dysfunction -is independent CVD risk factor
- Normal BP classification:: SBP <120 DBP <
- Prehypertension classification:: -SBP 120- -DBP 80-
- Stage I hypertension classification:: -SBP 140- -DBP 90-
- Stage II hypertension classification:: -SBP >= 160 -DBP >= 100
solutions graded A+ 2024
- Hypertensive emergency:: -hypertensive encephalopathy -dissecting AAA -unstable angina -acute HF -pulmonary edema -acute RF -eclampsia
- Drugs used in clinic to lower BP in hypertensive urgency:: - furosemide 20mg -clonidine 0.2mg
- Accelerated HTN:: -clinical evidence of severe arteriolosclerosis -Grade 2/4 hypertensive retinopathy -poor prognosis if untreated -renal insufficiency w/o apparent cause except HTN
- Meds that can elevate BP:: -oral contraceptives -cyclosporine -tricyclic antidepressants -sympathomimetic decongestants
solutions graded A+ 2024
-corticosteroids -NSAIDS
- Mnemonic for secondary HTN causes: ABCDE: -Accuracy, aldosteronism, apnea -Bruits, bad kidneys -catecholamines, cushings, coarct -drugs, diet -endocrine, erythropoeitin
- Sleep apnea:: -CPAP
- Coarctation of aorta:: -htn in young person -decreased BP in LE -diminished or absent femoral pulses -CXR: post-stenotic dilation of aorta
- Pseudohypertension:: -wall of brachial artery is rigid from calcification -in office test: see if radial pulse obliterates when cuff is inflated. -suspect in patient with dizziness/weakness who has normal to high cuff reading on tx.
- Renovascular HTN clinical findings increase probability: -unilateral
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-LFT
- Heart exam:: -louder S2 or systolic ejection murmur, split S2, high-pitched diastolic murmurs -LVH (heave or EKG) -echo
- Kidney exam:: -UA -Cr -microalbumin -renal artery bruits -potassium (high can be renal, low aldosterone excess)
- JNC8 BP goals:: -SBP <140mm (150 if >60 yrs old) -DBP <90mm -DM, HF, CRF: <140/90mm
- BP goals in older adults:: -<140/90: 65- -140-145 for 80+
- HTN lifestyle modifications:: -weight loss -DASH diet -decreased salt intake
solutions graded A+ 2024
-limit ETOH -tobacco cessation
- Alternative tx options:: -Aerobic exercise: Level A -acupuncture: Level B -guided breathing: Level B 60. BP algorithm:
- Potassium in HTN:: -increasing potassium lowers BP -low sodium diet is high in potassium -high sodium diet lowers potassium
- Sodium recommendations:: -2,300 mg for avg adult -1500mg for persons with HTN, middle-aged+, blacks
- Recommended amount of sodium intake per day:: 1500mg
- Stage I HTN DOC in blacks:: CCB or Thiazide
- Stage I HTN DOC nonblack <60 years old:: -ACEI or ARB
- Stage I HTN DOC nonblack >60 years old:: CCB or Thiazide
solutions graded A+ 2024
-caution in gout/hyperlipidemia -may increase lipids -reduces urinary calcium; may prevent stones -NOT EFFECTIVE with high serum Cr/impaired RF
- Loop diuretics:: -used in pts with renal insufficiency -not in gout -may increase calcium loss causing osteoporosis
- Furosemide, bumetanide, torsemide:: loop diuretics
- Non-thiazide diuretics:: -indapamide -increases glucose -prolong QT interval 80. Potassium sparing diuretics Mineralocorticoid antagonist:: -blocks aldosterone effects -caution if renal insufficiency -has anti-androgen effects -often 3rd or 4th drug add-on
- Potassium sparing diuretics:: spironolactone
- Epithelial sodium transport channel antagonist:: -amiloride and
solutions graded A+ 2024
triamterene -K+ retention
- ACEI:: -blocks conversion of angiotensin I to II -lower peripheral vascular resistance and BP -no reflex stimulation of HR and contractility -preferred in DM, MI, HF -reduce morbidity and mortality in HF and MI -retard progression of diabetic renal disease and hypertensive nephrosclerosis
- ACEI or ARB + diuretic + NSAID or ASA can:: -lead to acute RF
- ACEI and serum Cr:: -can increase serum Cr by 30%; it reduces pressure w/in glomerulus and decreases filtration. -reversible
- ARB:: -blocks action of angiotensin II -used in HF, DM -NOT in pregnancy
- What drugs should you not combine?: ACEI with ARB or renin inhibitors
- CCB:: -widely variable effects on heart
solutions graded A+ 2024
- Alpha-adrenergic antagonist: -blocks alpha 1 adrenergic receptors causing vasodilation -increased incidence of HF -not first line agents
- Centrally acting BP agents:: -clonidine -excessive sleepiness, fatigue, BP rebound -start dosing at bedtime
- first line combo therapy:: -consider if >20/10mmHg above goal
- orthostatic hypotension:: -at least 20mmHg fall in systolic -at least 10mmHg fall in diastolic -sx of cerebral hypoperfusion such as dizzines
- ACEI + thiazide:: -preferred; good -decreases risk of hypokalemia
- ACEI + dihydro CCB:: -ACEI reduces edema from dihydro CCB -use ARBS when unable to tolerate ACEI
- Caution in lowering DBP to quickly:: -AHA recommends caution in lowering DBP quickly or below 60mmHG in those with occlusive CAD, myocardial ischemia,
solutions graded A+ 2024
60 years old, diabetics
- African Americans:: -do not respond well to ACEI or BB; -do better with diuretics and CCB
- Elders with isolated systolic HTN:: -low dose thiazide or log- ating CCB reduces mortality and morbidity
- LVH:: -ACEI or ARB reduce ventricular mass and help with remodeling
- diastolic dysfunction:: -CCB or BB may provide symptom relief and modest decrease in contractility
- adverse effect of ACEI: -cough -angioedema -teratogenic
- adverse effect ARB:: -angioedema -teratogenic
- adverse effect CCB:: -ankle edema
- adverse effect hydralazine:: -lupus like syndrome -peripheral sensory neuropathy
- adverse effect of diuretics:: -gouty arthritis
solutions graded A+ 2024
- JNC8 preferred agents:: -general population: thiazid e CCB ACEI ARB -black: CCB or thiazide -DM: thiazid e CCB ACEI ARB -CKD: ACE ARB
- If goal BP not met after 1 month tx:: -increase dose of initial drug or -add second drug
solutions graded A+ 2024
- If goal BP not met with 2 meds:: -add and titrate third med -do not use ACEI or ARB together
- JNC8 three choices to dose meds:: 1. titrate to max dose, then add second drug. 2.Add second drug before achieving max dose of initial drug. 3.start with two drugs at some time if SBP >160 and/or DBP>100mmHG
- Refractory HTN is usually due to:: -ETOH -non-adherence -hyperaldosterone
- Resistant HTN defined as:: on 3 drugs w/o control and one must be diuretic.