NR507/ NR 507 MIDTERM EXAM (LATEST 2024/ 2025 UPDATE) ADVANCED PATHOPHYSIOLOGY, Exams of Nursing

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NR507/ NR 507 MIDTERM EXAM (LATEST 2024/ 2025

UPDATE) ADVANCED PATHOPHYSIOLOGY |

COMPLETE GUIDE WITH QUESTIONS AND

VERIFIED ANSWERS| 100% CORRECT |GRADE A –

CHAMBERLAIN

3 characteristics of bronchitis ...ANSWER... bronchial inflammation hypersecretion of mucus chronic productive cough for at least 3 consecutive months for at least 2 successive years 3 layers of the bronchioles ...ANSWER... innermost layer middle layer - lamina propria outermost layer Acute Kidney Injury ...ANSWER... Sudden decline in kidney function with a decrease in GFR and an increase in plasma creatinine and BUN levels - results in oliguria After air passes through the trachea where does it go? ...ANSWER... goes into the left or right bronchi

Afterload ...ANSWER... the amount of resistance to open the semilunar valves and eject of blood from the ventricle alveolar hyperinflation ...ANSWER... When air is unable to move out of the alveolar like it should due to bronchial walls collapsing around possible mucus plug thus trapping air inside anemia risk factors ...ANSWER... acute or chronic blood loss, increased hemolysis, inadequate dietary intake or malabsorption, bone marrow suppression, age angiotensin converting enzyme (ACE) ...ANSWER... an enzyme that converts angiotensin I to angiotensin II Ascending infection ...ANSWER... - urethra to bladder, and then to kidney

• due to: bacteria from residual fecal contamination Asthma ...ANSWER... Chronic disease due to bronchoconstriction and an excessive inflammatory response in the bronchioles average amount of preload? ...ANSWER... 120-130 mls Azoetmia ...ANSWER... presence of elevated plasma creatinine

benign prostatic hyperplasia ...ANSWER... benign growth of cells within the prostate gland Biventricular failure ...ANSWER... unresolved left sided heart failure will increase pressure on the right side of the heart contributing to right sided heart failure as well Bladder anatomy ...ANSWER... - ureter

• bladder
• urethra blood cell formation in adults over 20 ...ANSWER... red marrow in large bones
• illium, vertebrae, cranium, jaw, sternum, ribs, humerus, and femur Blood cell formation in chidren 0-5 years old ...ANSWER... red marrow of all bones to make blood cells blood hydrostatic pressure ...ANSWER... the pressure produced by a fluid against a surface BPH (benign prostatic hyperplasia) ...ANSWER... Age-associated prostate gland enlargement that can cause urination difficulty.

BPH treatment ...ANSWER... - Alpha-adrenergic antagonists: terazosin, doxazosin

• 5 - alpha reductase inhibitors: finasteride, dutasteride
• Transurethral prostatectomy
• Open prostatectomy Bronchioles ...ANSWER... smaller passageways that originate from the bronchi that become the alveoli bronchitis ...ANSWER... inflammation of the bronchial tubes cardiac reserve ...ANSWER... difference between resting and maximal CO; should be about 4-5x as high but does decrease 1% per year after age 30 causes of anemia ...ANSWER... - impaired RBC production
• excessive blood loss
• increased RBC destruction Causes of bronchitis ...ANSWER... - long term exposure to environmental irritants
• repeated episodes of acute infection (RSV infection in early infancy)
• Factors affecting gestational childhood lung development (preterm birth)

causes of hemolytic anemia ...ANSWER... infection transfusion reaction hemolytic disease of the newborn (Rh incompatibility) autoimmune reaction drug induced causes of high output failure ...ANSWER... Severe anemia Nutritional deficiencies Hyperthyroidism Sepsis Extreme febrile state Causes of intrarenal disease ...ANSWER... ATN Acute glomerulonephritis causes of kidney stones ...ANSWER... Family HX, chronic dehydration and infection, dietary factors, medications, imobility. Stoned more common in men than women usually ages 30/50. Causes of left sided heart failure ...ANSWER... systemic hypertension left ventricle MI LV hypertrophy Aortic SL valve or bicuspid valve damage Secondary to right heart failure

Causes of postrenal disease ...ANSWER... BPH Calculi Inflammation Tumors Causes of right sided heart failure ...ANSWER... - pulmonary disease

• pulmonary hypertension
• RV MI
• RV Hypertrophy
• pulmonary SLV or tricuspid valve damage
• secondary to left heart failure Causes of tubular necrosis ...ANSWER... - being post operative
• severe sepsis
• burns
• trauma
• contrast chemical use in medical imaging procedures Chronic kidney disease ...ANSWER... progressive, irreversible deterioration in renal function Labs: elevated BUN, Cr Phosphorus.

Rx: meds for hypertension, statins, epoetin, diuretics, calcium, LOW protein, low salt, restrict K, phosphorus (no chicken, milk, legumes, carbonated drinks), dialysis. clinical indicators of glomerulonephritis ...ANSWER... - proteinuria

• hematuria
• edema
• azotemia
• oliguria
• coagulation cascade activation Conditions associated with renal failure ...ANSWER... - congenital abnormalities in the urethral tract development
• kidney and bladder cancer
• infections
• glomerulonephritis
• acute/ tubular necrosis
• AKI cor pulmonale ...ANSWER... right-sided heart failure Descending infection ...ANSWER... The blood can carry bacteria from a focus of infection in another part of the body to the kidneys. The bacteria then pass with the urine down the ureters to the bladder.

Describe how blood flows to become oxygenated ...ANSWER... - deoxygenated systemic blood flows from the vena cava to R atrium

• Tricuspid valve opens to flow to R ventricle
• Pulmonary semilunar valve opens and blood flows to the alveolar capillaries for gas exchange from the pulmonary trunk and L & R pulmonary arteries
• blood goes from alveolar capillaries to pulmonary veins to return oxygenated blood to the left atrium
• bicuspid valve opens to allow blood to go to left ventricle
• aortic semilunar valve opens and blood goes to the aorta
• aorta pushes oxygenated blood out to the body development of anemia due to gastrectomy ...ANSWER... loss of intrinsic factor from surgery results in the loss of protein necessary for vitamin B12 absorption an can lead to anemia Effect of hyperinflation of the alveolar ...ANSWER... - expanded thorax and hypercapnia (retention of CO2)
• respiratory acidosis ejection fraction ...ANSWER... measurement of the volume percentage of left ventricular contents ejected with each contraction Erythrocyte function ...ANSWER... transport oxygen and carbon dioxide

Erythrocyte life span ...ANSWER... 120 days Erythropietin ...ANSWER... Produce: Kidney (small amount in liver) Released: Kidney Target: Bone Marrow Functions: Stimulates bone marrow to produce more red blood cells filtration (kidney) ...ANSWER... movement of solutes from blood to filtrate at bowman's capsule 20% of the blood that goes through the glomerulus is passed as filtrate into the bowman's capsule depends on the hydrostatic and oncotic pressures/ starling forces between the glomerulus and bowman's capsule hydrostatic pressure: a lot higher in the glomerulus (move into the nephron/bowman's capsule) oncotic pressure: higher in the blood/glomerulus than in the bowman's capsule (move into the blood/glomerulus) hydrostatic pressure is greater so there will be movement into bowman's capsule

usually favors the filtrate to go into the bowman's capsule each persons full body is filtered about every 40 minutes filtration (kidney) ...ANSWER... movement of solutes from blood to filtrate at bowman's capsule 20% of the blood that goes through the glomerulus is passed as filtrate into the bowman's capsule depends on the hydrostatic and oncotic pressures/ starling forces between the glomerulus and bowman's capsule hydrostatic pressure: a lot higher in the glomerulus (move into the nephron/bowman's capsule) oncotic pressure: higher in the blood/glomerulus than in the bowman's capsule (move into the blood/glomerulus) hydrostatic pressure is greater so there will be movement into bowman's capsule usually favors the filtrate to go into the bowman's capsule each persons full body is filtered about every 40 minutes

function of hemoglobin ...ANSWER... In red blood cells, carries oxygen from the lungs to body's tissues and returns carbon dioxide from tissues back to lungs. It also maintains the shape of red blood cells. glomerulonephritis ...ANSWER... inflammation of the glomeruli of the kidney heart failure ...ANSWER... cardiac dysfunction caused by the inability of the heart to provide adequate CO resulting in inadequate tissue perfusion Hematopoiesis ...ANSWER... formation of blood cells hematopoietic stem cells ...ANSWER... The stem cells that give rise to RBC WBC and platelets through the process of haematopoiesis. hemolytic anemia ...ANSWER... premature destruction of RBCs hemolytic anemia is what kind of anemia ...ANSWER... normocytic normochromic anemia High output failure ...ANSWER... inability of the heart to pump sufficient amounts of blood to meet the circulatory needs of the body despite normal blood volume and cardiac contractility

How does a hematopoietic stem cell produce a red blood cell ...ANSWER... hematopoietic stem cells produces an unndifferentiated hemocytoblast

• erythropoietin binds to it and createsa a proerythroblast
• cell develops into an erythrocyte 7 days later How does Aortic SL valve or bicuspid valve damage lead to heart failure ...ANSWER... damage leads to back flow into the left atrium or ventricle after ejection how does chronic bronchitis lead to respiratory acidosis? ...ANSWER... hyperinflation of the alveoli causes CO2 retention How does heart failure progress from hypertension? ...ANSWER... - high systemic vascular pressure causes high after load requires the left ventricle to increase contraction force to eject the blood
• damage causes reduced ejection fraction and left ventricle gets tired and becomes unable to eject normal amount of blood
• increased amount of blood remaining in left ventricle and increased left ventricle preload causes the left atrium unable to eject the normal amount of blood into the left ventricle

• blood volume and pressure backs up into the pulmonary veins
• increased pressure will force fluid from the pulmonary capillaries into the pulmonary tissues how does hyperinflation occur? ...ANSWER... the ongoing inflammatory process of asthma produces mucus and pus plug that the bronchial walls collapse around How does LV hypertrophy lead to left sided heart failure ...ANSWER... The hypertrophy is secondary to cardiac damage resulting in an enlarged by weaker structure that holds more blood How does the lamina propria effect the lungs in regards to asthma ...ANSWER... the WBCs protective feature goes into overdrive causing an inflammatory response that damages host tissue How does the thickening and rigidity of bronchial basement membranes effect the lungs? ...ANSWER... leads to further narrowing of the bronchial passageways Hypertrophy and hyperplasia of goblet cells do what in the bronchials ...ANSWER... promotes hypersecretion of mucus Intrarenal disease ...ANSWER... disease or damage within the kidney

Kidney Anatomy ...ANSWER... renal artery renal vein cortex, medulla, renal pelvis ureter renal pyramid nephron kidney stone treatment ...ANSWER... high fluid intake, decreasing dietary intake of stone-forming substances, stone removal kidney stones ...ANSWER... Solid crystalline masses formed in the kidney, resulting from an excess of insoluble salts or uric acid crystallizing in the urine; may become trapped anywhere along the urinary tract. lamina propria ...ANSWER... the middle layer of the bronchioles Left sided heart failure characteristic ...ANSWER... inability of the left ventricle to provide adequate blood flow into systemic circulation MOA of anticholinergic drugs for asthma ...ANSWER... the parasympathetic system is stimulated by the vagal nerve to release acetylcholine which binds to the cholinergic receptors of the respiratory tract to cause bronchial constriction = decreased airflow

• blocking the cholinergic receptors prevents acetylcholine binding preventing the bronchial constriction most common irritant with bronchitis is? ...ANSWER... tobacco product smoke

Nephron Anatomy ...ANSWER... 1. glomerulus

2. bowman's capsule
3. collecting duct
4. tubule
5. capillary normocytic normochromic anemia ...ANSWER... Characterized by red cells that are relatively normal in size and hemoglobin content but insufficient in number Pathogenesis of bronchitis ...ANSWER... - Exposure to airborne irritants

• Irritant activates bronchial smooth muscle constriction and mucus secretion
• Triggers release of inflammatory mediators from immune cells located in the lamina propria pathogenesis of primary glomerulonephritis ...ANSWER... - infection triggers of immune response to cause formation of antibodies
• antibodies form complexes with the pathogen that should be rapidly phagocytized by WBC
• in glomerulonephritis the Ag-Ab complexes are not phagocytized in a timely manner and continue to circulate in the blood stream
• the Ag-Ab complexes get trapped in the narrow vasculature of the glomerular capillaries

• build up of the Ag-Ab complexes signals that immune system and the complement system and WBC infiltration of the site
• Complement protein with enzymes released by phagocytic cells attack the complexes and cause collateral damage to the glomerular area
• Damage weakens thee glomerular structure and plasma proteins with blood leak into the tubular system and pass out into the urine Pathophysiology of asthma (5) ...ANSWER... - airway inflammation, bronchial hyper-reactivity and smooth muscle spasm
• excess mucus production and accumulation
• hypertrophy of bronchial smooth muscle
• airflow obstruction
• decreased alveolar ventilation Pathophysiology of tubular necrosis ...ANSWER... - ischemia or nephrotoxin exposure occurs to the renal tubules
• inflammation and tubular injury occur
• cast formation and tubular obstruction occurs
• tubular injury, leakage, increased glomerular pressure causes decreased capillary perfusion further decrease in GFR occurs
• oliguria results Perfusion ...ANSWER... The supply of oxygen to and removal of wastes from the cells and tissues of the body as a result of the flow of blood through the capillaries.

polycystic kidney disease ...ANSWER... - Mutant PKD genes cause fluid accumulation in kidney tubules "cysts"

• The cysts can be the size of grapes or oranges and compress and destroy nephrons polycythemia vera ...ANSWER... condition characterized by too many erythrocytes; blood becomes too thick to flow easily through blood vessels postrenal disease ...ANSWER... obstruction in the lower urinary tract that prevents urine flow from the kidneys Potter syndrome ...ANSWER... Syndrome characterized by bilateral renal agenesis and incompatibility of live birth Prerenal disease ...ANSWER... decreased blood flow to and through the kidney prerenal disease causes ...ANSWER... - hypotension
• decreased cardia output
• decreased blood volume Process of high output failure ...ANSWER... - impaired oxygen delivery of excessive tissue oxygen demands cause tissue hypoxia

• catecholamines initiation increase HR and stroke volume
• increased cardiac output is produced but depletes cardiac muscle reserve overtime and leads to low output failure over time Progression of right sided heart failure ...ANSWER... - damage causes the right ventricle to increase contraction force to eject/unload the blood
• over time EF is reduced and right ventricle us unable to eject the normal amount of blood
• the blood remaining in the RV increases and RA preload increases until the RA is unable to eject the normal amount of blood into the RA
• the amount of blood remaining in the right atrium increases causing an increase in RA preload
• blood volum enad pressure then backs up into the vena cava and systemic veins purpose of the lamina propria ...ANSWER... white blood cells are present to help protect the airways

reabsorption (kidney) ...ANSWER... movement of solutes from filtrate to blood things taken back that were secreted of filtered by the kidney renal agenesis ...ANSWER... unilatral or bilateral failure of the kidneys to develop in utero results of chronic bronchitis/ low perfusion ...ANSWER... cyanosis right to left shunting chronic hypoxemia right sided heart failure ...ANSWER... inability of the right ventricle to provide adequate blood flow into the pulmonary circulation Right to left shunting ...ANSWER... when blood passes from the right ventricle through the lungs and to the left ventricle without perfusion Role of macrophages ...ANSWER... - In Innate:

1. Phagocytosis PRR or opsonization w/ complement
2. Secrete Cytokines: Recruit more cells, inflammation, fever, etc.

• In Adaptive:

1. Phagocytosis: opsonization with complement or Abs

2. Secrete cytokines: recruit more cells etc.
3. Antigen presentation: peptides from the broken down pathogen are displayed on surface of the cell. secretion (kidney) ...ANSWER... movement of solutes from blood to filtrate anywhere besides bowman's capsule able to secrete salts, acids, bases and urea directly into the tubule via active or passive transport what is secreted into the tubule depends on what the body needs at that time ex. eating a lot of protein nitrogen waste is a product of protein metabolism (ammonia) liver converts ammonia to urea and the kidneys secreted urea into the tubule for secretion also possible to eliminate products that are in excess in the blood -- potassium, hydrogen, metabolites or medications can secrete things that were too larger to fit through the glomerulus's pore

signs and symptoms of right sided heart failure ...ANSWER... jugular vein distension hepatosplenomegaly peripheral edema sliding filament theory ...ANSWER... theory that actin filaments slide toward each other during muscle contraction, while the myosin filaments are still Stenosis of a heart valve, may result in what? ...ANSWER... Narrowing of the heart valves means that blood moves with difficulty out of the heart. Results may include chest pain, edema in the feet or ankles, and irregular heartbeat. and hypertrophy Stenosis of heart valve ...ANSWER... A narrowing of the valve opening, causing turbulent flow and enlargement of the emptying chamber Stimulation of what set a resting HR (chronotropic state) ...ANSWER... parasympathetic system structure of the lamina propria ...ANSWER... embedded with connective tissue cells and immune cells Troponin-Calcium Binding ...ANSWER... Calcium binds to troponin on the thin filament

tubular necrosis ...ANSWER... the renal tubules cells are highly sensitive to low oxygen levels or presence of toxins and leads to tubular necrosis vesicoureteral reflux ...ANSWER... Abnormal ureter-bladder connection allowing retrograde flow of urine from bladder to ureters and/or kidneys What acid-base disorder is seen in chronic bronchitis? ...ANSWER... respiratory acidosis What are 5 s/s of asthma ...ANSWER... coughing wheezing shortness of breath rapid breathing chest tightness What are characteristics of epithelial cell metaplasia? ...ANSWER... squamous cells become nonciliated and are less protective; allow passage of toxins and WBCs What are most cases of AKI caused by? ...ANSWER... prerenal issues

What are the atrioventricular valves? ...ANSWER... tricuspid and bicuspid (mitral) valves What are the semilunar valves? ...ANSWER... pulmonary and aortic valves What are the two parts of the cardiac cycle? ...ANSWER... diastole and systole What are two anticholinergic drugs used for asthma ...ANSWER... tiotropium and ipratropium What are two common causes of hypovolemia ...ANSWER... dehydration and hemorrhage what can cause an increase in afterload ...ANSWER... systemic hypertension valve disease COPD (pulmonary hypertension) What can cause decreased preload ...ANSWER... cardiac tamponade and hypovolemia What can cause increased preload ...ANSWER... CHF and hypervolemia

what can decrease afterload ...ANSWER... hypotension or vasodilation What can extreme vagal response result in? ...ANSWER... life threatening bradycardia What can uncontrolled tachycardia lead to? ...ANSWER... reduced stroke volume and fatigue What causes blood to move from the atria to the ventricles ...ANSWER... gravity and atriole systole What causes the S1 heart sound? ...ANSWER... Bicuspid/Mitral and Tricuspid valves closing What causes the S2 heart sound? ...ANSWER... closing of semilunar (aortic and pulmonary) valves What causes the semilunar valves to close? ...ANSWER... ventricles relax and intraventricular pressure falls, blood flows back from the arteries, and fill the cusps of the semilunar valves What causes the semilunar valves to open? ...ANSWER... As ventricles contract and intraventricular pressure rises, blood is pushed up against the SL valves, forcing them to open