bazicna radiologija urinarnog sistema, Beleške' predlog Radiologija. Univerzitet u Beogradu

bazicna radiologija urinarnog sistema, Beleške' predlog Radiologija. Univerzitet u Beogradu

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DOI: 10.5152/eurjrheum.2015.0032

Basic radiological assessment of synovial diseases: a pictorial essay

Abstract The synovium is a specialized tissue lining the synovial joints, bursae, and tendon sheaths of the body. It is affected by various localized or systemic disorders. Synovial diseases can be classified as inflammatory, infectious, degenerative, traumatic, hemorrhagic, and neoplastic. Damage in other intraarticular structures, particularly cartilages, generally occurs as a part of pathologic processes involving the synovi- um, leading to irreversible joint destruction. Imaging has an essential role in the early detection of synovial diseases prior to irreversible joint damage. Obtaining and understanding characteristic imaging findings of synovial diseases enables a proper diagnosis for early treatment. This article focuses on the recent literature that is related with the role of imaging in synovial disease. Keywords: Synovium, synovial hypertrophy, synovitis, magnetic resonance imaging

Introduction The synovium is a thin specialized membrane lining the diarthrodial joint surfaces, bursae, and tendon sheaths. Synovium coats the inner surface of the fibrous joint capsule, fat pads, and intraarticular ligaments. Other intraarticular structures such as the articular cartilage, menisci, labra, and small bone bare area are not covered by the synovium (1, 2). The synovium provides nutrition and lubrication to the joint cartilage by fluid secretion (3).

Synovial diseases are classified as inflammatory, infectious, degenerative, traumatic, hemorrhagic, and neoplas- tic. There are also tumor-like conditions such as pigmented villonodular synovitis, nodular synovitis, giant cell tumor of tendon sheath, synovial chondromatosis/osteochondromatosis, and lipoma arborescens (1, 3).

Damage in other intraarticular structures, particularly cartilages, generally occurs as a consequence of pathologic processes involving the synovium, leading to irreversible joint destruction (4). Imaging plays a crucial role in the early detection of synovial diseases prior to the occurrence of irreversible joint damage. Plain radiography, ultrasonography (US), and magnetic resonance imaging (MRI) are utilized in the diag- nosis and follow-up of synovial diseases. Gadolinium-enhanced MRI is the best tool to diagnose synovial disorders (1, 3).

MRI findings of synovial diseases include thickening of the synovium, hyperintensity on T2-weighted imag- es (T2WI) due to water accumulation, and prominent contrast enhancement on postcontrast T1-weighted images (T1WI). Because of the high soft-tissue contrast resolution of MRI, besides synovitis diagnosis, joint effusion, articular cartilage, subchondral bone, ligaments, muscles, and juxtaarticular soft tissues can be evaluated (5). Herein, each of these synovial diseases were explained in detail.

Rheumatoid arthritis Rheumatoid arthritis (RA) is a joint-based chronic, progressively destructive inflammatory systemic dis- ease. Synovial hypertrophy occurs initially, and locally invasive behavior causes cartilage destruction and bone erosions. RA proceeds progressively, ultimately causing multiple deformities. All synovial joints can be affected; however, metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints are the most frequently involved ones. Bilateral and symmetric involvement is a rule and atlantoaxial joint particularly involved in the spine (6, 7). RA also has extraarticular musculoskeletal manifestations such as rheumatoid nodules, enthesopathy, bursitis, tenosynovitis, and tendon rupture.

Radiographs show typical findings such as soft-tissue swelling, marginal erosions, periarticular osteopenia, joint space narrowing, and joint subluxation. Besides bone alterations, this imaging modality is unable to display synovitis at an early stage. Identification of early changes facilitate the prevention of joint damage

Aynur Turan1, Pınar Çeltikçi1, Abdurrahman Tufan2, Mehmet Akif Öztürk2

Invited Review

1 Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital Ankara, Turkey

2 Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Turkey

Address for Correspondence: Aynur Turan, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Radyoloji Anabilim Dalı, Ankara, Türkiye

E-mail: [email protected]

Submitted: 08.04.2015 Accepted: 01.07.2015 Available Online Date: 29.01.2016

Copyright 2015 © Medical Research and Education Association

via more effective therapies, promoting the im- portance of advanced imaging methods (3, 8).

US and MRI can detect synovial proliferation, tenosynovitis, and bone erosions. Fat saturated T2WI and postcontrast fat saturated T1WI are useful for the evaluation of synovitis (Figure 1a), tenosynovitis (Figure 1 a-c), and adjacent soft tissues. Also, postcontrast fat saturated T1WI is essential to distinguish synovial prolif- eration from joint effusion (Figure 1a, b). Bone marrow edema and erosions are detected on MRI at the same time (6, 8). Dynamic MRI de- terminates active disease by demonstrating a synovial enhancement pattern (9). Pannus is defined as persistent synovitis, hypervascular synovial tissue, and destruction of cartilage and bone. This lesion is responsible for the ir- reversible joint destruction due to locally inva- sive properties. Pannus has similar MRI findings to synovitis with associated bone and cartilage disruption (10).

Psoriatic arthritis Psoriatic arthritis (PsA) is one of the seroneg- ative spondyloarthropathy-spectrum diseases related with psoriasis. The prevalence is ap- proximately 30% in psoriatic cases, and there is no gender predilection (11, 12).

Joint damage appears at the early stages of the disease; thus, the detection and treatment of joint inflammation is crucial. Clinical findings alone are generally insufficient to determinate the severity of the disorder. High-resolution US and MRI provide an accurate and early assess- ment of synovial inflammation. Imaging is also used to differentiate PsA from other arthropa- thies such as RA. Hand and feet finger joints are most commonly affected, but sacroiliac joints, spine, knees, elbows, ankles, and shoulders can be involved. Sausage digit is a form of dactylitis that is described as a swelling of the whole fin- ger in PsA (11, 13).

On radiography images, the best diagnostic clue for PsA is the simultaneous presence of eccentric erosive changes and new bone formation at the same joints. PsA particularly affects the distal interphalangeal (DIP) joints. Periostitis, pencil-in-cup deformities, joint space narrowing, ankylosis, osteolysis, arthri- tis mutilans, and ivory phalanx are the oth- er radiographic manifestations of PsA. Axial skeletal involvement presents with syndes- mophyte formation, sacroiliitis, atlantoaxial subluxation, apophysial joint ankylosis, and ligament calcification. DIP involvement and the asymmetric pattern without periarticular osteoporosis are the factors that differentiate PsA from RA. However, RA primarily affects

MCP with osteoporosis, and bone prolifera- tion is not a feature of RA (11, 14).

MRI is very sensitive to inflammatory and de- structive changes in PsA. MRI allows the de- tection of synovitis, osteitis, erosions (Figure 2a, b), effusions, enthesitis, tenosynovitis, and dactylitis in addition to the involvement of axi- al skeleton and sacroiliitis. This method also de- termines disease activity and response to the treatment (11).

Gout arthropathy Gout is a disease that is characterized with deposition of monosodium urate (MSU) crys- tals in soft tissues and joints secondary to hy- peruricemia. The deposition of MSU crystals activate the inflammatory process and cause gout tophi formation. Gout tophi are foreign body granulomas that include macrophages and MSU crystals. Arthropathy develops sec- ondary to the inflammatory reaction. Chronic arthropathy develops after several years of recurring acute arthritis attacks. Thus, chronic gout arthritis generally affects older patients. The first MTP joints and knees are the most fre- quently affected joints. The diagnosis is gener- ally straightforward and based on clinical, labo- ratory, and radiological evaluation. Sometimes, biopsy may be required (12, 15).

Radiographic findings include dense nodular soft tissue masses, well-defined bony erosions, and bony proliferation (12).

MRI findings are quite non-specific. Gout tophi frequently mimic other conditions such as tu- mor or infection (16) (Figure 3a, b). Dual-en- ergy computed tomography (DECT) is a new technology that provides a non-invasive deter- mination of MSU crystal deposits. DECT differ- entiates MSU crystals from calcium via specific attenuation characteristics. This technology is not only useful for diagnosis but also useful in monitoring of the disease (15, 17). Therefore, DECT is the test of choice in patients with sus- pected gouty arthritis.

Juvenile idiopathic arthritis Juvenile idiopathic arthritis (JIA) is one of the most common manifestations of rheumatic disease with an unknown etiology in the pedi- atric group. This entity is composed of all cases of IA that occur before the age of 16 years and persist for at least 6 weeks. The knee is the most commonly affected joint (1).

The International League of Associations for Rheumatology classifies JIA into seven sub- groups, which are listed below (18); - Systemic arthritis: 10–20% of JIA cases are

characterized with polyarticular involve- ment and may be associated with rash, hepatosplenomegaly, adenopathy, fever, myalgias, and serositis.

- Oligoarthritis: The most common sub- group in which 1–4 joints are affected in the first 6 months from the onset of the disease .

Eur J Rheumatol 2015Turan et al. Radiology of synovial disease

Figure 1. a-c. 60 year old woman with RA; axial post-contrast fat-saturated T1W consecutive images (a, b) and sagittal image (c) of the right hand revealed contrast enhancement, indicating synovial hypertrophy of the second metacarpophalangeal (MCP) joint and tenosynovitis of flexor pollicis longus and extensor tendons of the third and fourth finger (from the courtesy of Dr. A. Turan)

a c


- Rheumatoid factor (RF)-negative polyar- thritis: RF-negative patients with at least ≥5 joints affected.

- RF-positive polyarthritis: RF-positive pa- tients with at least ≥5, similar to the adult form of RA.

- Psoriatic arthritis: Patients with arthritis and psoriasis or arthritis accompanied by ≥2 of the following: dactylitis, nail pitting, onycholysis, rash, or positive family histo- ry. Generally, the knee, ankle, DIP, and PIP joints of the hands and feet are affected.

- Enthesitis-related arthritis: Arthritis and en- thesitis or arthritis or enthesitis accompa- nied by ≥2 of the following: inflammatory lower back pain; sacroiliac joint tenderness; positive HLA-B27 antigen; male over 6 years of age at onset; acute anterior uveitis; or positive family history of enthesitis-re- lated arthritis, sacroilitis with inflammatory bowel disease, or Reiter syndrome.

- Undifferentiated arthritis: Remaining pa- tients that fit into none or at least two subgroups.

Radiographic findings include bone erosions, joint space narrowing due to cartilage destruc- tion, and growth retardation. Although radi- ography can demonstrate chronic irreversible joint damage, it is unable to display cartilage

destruction. Cases should be identified during the preradiographic period to administer ap- propriate treatment. MRI is an effective imag- ing modality for this task (1, 18).

On MRI, the most common finding is synovitis that appears hypointense on T1WI, hyperin- tense on T2WI, and marked enhancement fol- lowing intravenous (IV) contrast administration (Figure 4a, b, 5a, b). In some cases, the menis- cus may be smaller in size because of synovial hypertrophy. Also, some additional findings are joint effusion, Baker cyst, lymphadenopathy in the popliteal fossa, extraarticular tenosynovitis, and rice bodies (Figure 4a) (18).

Pigmented villonodular synovitis Pigmented villonodular synovitis (PVNS) is a form of villonodular proliferation of synovium with hemosiderin pigment deposition. This entity may develop in the bursa and tendon sheaths as well and named as pigmented vil- lonodular bursitis (PVNB) and pigmented vil- lonodular tenosynovitis (PVNTS), respectively. PVNS is considered to be a benign neoplasm, but rare cases of a malignant transformation of PVNS is reported (19, 20).

The most common type of intraarticular PVNS is the diffuse form, but a localized form of PVNS

may rarely be encountered. The clinical and radiological findings of these two forms are different (19).

Diffuse PVNS is most commonly presented with pain, swelling, and restriction of move- ment. The lesion generally affects the knee. Other joints such as the hip, ankle, shoulder, and elbow are rarely involved (19, 20).

Radiographs are non-specific for diagnosis and can reveal soft-tissue swelling without calcifi- cation with preserved joint space (Figure 6a). Cartilage disruption and degenerative arthritis develops at the chronic stage (20).

US findings of PVNS are joint effusion and sy- novial thickening with villous projections. The local form of appearance is different, in which only a nodulary soft tissue lesion is depicted. Doppler US shows hypervascularity of the le- sions (20).

MRI reveals prominent diffuse villous or nodular proliferation of synovium and associated joint effusion. Synovial thickening is visualized as an intermediate to low signal intensity on T1WI. There are low signal intensity areas due to the hemosiderin on T2WI. Particularly, hemosiderin appears as blooming artifacts on gradient echo (GRE) images because of its magnetic suscep- tibility, which is is almost pathognomonic in all forms of PVNS (Figure 6b). Lesions show evident contrast enhancement after IV gadolinium ad- ministration (20, 21) (Figure 6c).

Surgical resection is the preferred treatment option, but recurrence rates are high.

The localized form of PVNS commonly affects the knee, particularly the infrapatellar region, and also affects the suprapatellar and posterior intercondylar area at times. Generally, radio- graphs are negative, but soft-tissue opacity is occasionally observed. US reveals only a nod- ulary soft tissue lesion. On MRI, it is a well-de- fined nodulary lesion including hemosiderin pigments, and postcontrast images displays the contrast enhancement (22) (Figure 7a, b).

Giant cell tumor of the tendon sheath Giant cell tumors of the tendon sheath (GCTTs) are known as a tumoral lesion; however, it is a benign proliferative lesion of synovium such as PVNS and PVNB.

GCTTs commonly occur in the hand and are the second most common soft tissue tumor of the hand after ganglion cyst. Women are frequently affected, and patients generally present with a slowly growing, painless mass (23, 24).

Eur J Rheumatol 2015 Turan et al. Radiology of synovial disease

Figure 2. a, b. 28-year-old man with psoriasis; axial T1W (a) and proton-density SPAIR images (b) show bone erosion of the distal phalanges, inflammatory changes in adjacent soft tissues, and synovitis in the distal interphalangeal (DIP) joint of the fifth toe (from the courtesy of Dr. A. Turan)

a b

Radiography shows a soft tissue mass with ad- jacent bone erosion. US detects a well-defined lesion with a different echo texture, related to tendon sheath. GCTTs are hypervascular on Doppler US (23).

MRI depicts a well-defined tumor related to the tendon. Characteristically, the lesion con- tains hemosiderin pigments that cause a low to intermediate signal intensity on T1WI and T2WI. Moreover, on GRE images, the magnetic susceptibility of hemosiderin leads to the for- mation of blooming artifacts because of low signal intensity. After the contrast injection, the lesions show prominent enhancement (Figure 8). Additionally, MRI depicts the relationship of the tumor with soft tissues and joint space (23).

The differential diagnosis of GCTTs include the other soft tissue tumors and tumor-like lesions such as ganglion cyst, hemangioma, nerve sheath tumor, foreign body granuloma, syno- vial sarcoma, desmoids, and fibromatosis (23).

Although GCTTs are considered to be a benign lesion, the recurrence rate is high (23).

Synovial chondromatosis/osteochondromatosis Synovial chondromatosis/osteochondromato- sis (SC/O) is a rare monoarticular benign neo- plasm. This entity is characterized with chon- droid metaplasia in the synovium, resulting in the formation of chondral-osseous bodies in the intraarticular space. SC/O commonly affects joints with a predilection to the knee. Also, the involvement of bursas and tendons were reported. SC/O is frequent in the third to fifth decades, and the etiology is unknown. The clinical findings include pain, swelling, and restriction of motion. Chondral-osseous bod- ies that are supplied by the synovial fluid may enlarge with time. The method of treatment is surgical resection; however, incomplete re- section may result in recurrence. The local re- currence rate is approximately 25% following treatment (25, 26).

The radiographical appearance of SC/O is frequently pathognomonic. Typically, multi- ple chondral-osseous bodies that are similar in shape and size fill the joint space entirely. Moreover, these bodies may show a ring-and- arc pattern secondary to peripheral calcifica- tion or rarely form a conglomerate, mineralized mass form (Figure 9a). At the same time, joint effusion, osteopenia, and bone erosion can be present (25).

US reveals a heterogeneous mass with hy- perechogenic foci, which resembles chon- droid bodies. Osseous bodies show posterior

Eur J Rheumatol 2015Turan et al. Radiology of synovial disease

Figure 3. a, b. 57-year-old man with gouty arthritis; axial T1W (a) and proton-density SPAIR (b) images reveal tophi formation and bone erosions with accompanying bone marrow edema in the fourth proximal interphalangeal, first metatarsophalangeal, and interphalangeal joints with adjacent soft tissue involvement (from the courtesy of Dr. A. Turan)

a b

Figure 4. a, b. 15-year-old boy with oligoarticular juvenile idiopathic arthritis (JIA) who had knee pain for 1 year; proton-density SPAIR image (a) depicts Rice bodies inside Baker’s cyst (arrow). Post-contrast fat-sat- urated T1WI (b) displays enhancing of synovial proliferation (arrow) (from the courtesy of Dr. A. Turan)

a b

Figure 5. a, b. 12-year-old boy with familial Mediterranean fever and accompanying oligoartic- ular JIA of the right ankle. Sagittal proton-density SPAIR image (a) shows joint and tenosynovial effusion. Sagittal post-contrast fat-saturated T1WI (b) displays enhancing of synovial proliferation (from the courtesy of Dr. A. Turan)

a b

acoustic shadowing. The Doppler sonographic appearance of SC/O is hypovascular. CT is the best diagnostic modality for the visualization of osseous bodies (25).

MRI appearance depends on the calcification. Only 30% of patients have unmineralized chon- droid bodies. These appear iso-hypointense on T1WI and hyperintense on T2WI. Osseous bodies present as hypointense on both T1WI and T2WI (Figure 9b). GRE images reveal calci- fications as a marked hypointensity due to the magnetic susceptibility effects (Figure 9c). In

some cases, osseous bodies may contain fatty marrow and appear hyperintense on T1WI and T2WI (25).

Synovial sarcoma Synovial sarcoma (SS) is the fourth most common type of soft tissue sarcomas. Both genders are equally affected. SS is frequently seen in young adults. The clinical findings are non-specific and generally presents with pain and a slowly growing tumor. Frequently, most tumors are larger than 5 cm at the time of diag- nosis. However, superficial tumors can be de-

tected when they are smaller in size, and they show smooth contours with a homogenous structure, mimicking benign lesions. The local recurrence and distant metastasis rate is very high. A tumor size larger than 5 cm is consid- ered as a poor prognostic factor. SS may con- tain intratumoral calcification and necrosis. The most common location is lower extremities, specifically popliteal fossa. SS can be occasion- ally present in the intraarticular region (27, 28).

On the radiography images, there are generally specific findings. Soft tissue masses that con- tain calcification should suggest SS (3, 27).

US reveals a hypoechoic soft tissue mass. CT shows a soft tissue mass that contains necrosis, hemorrhagic areas, and punctate or peripheral calcifications (27).

MRI is the best imaging modality to character- ize the lesion and its relationship with the adja- cent structures. Generally, the mass is localized close to the bones and appears well-defined and shows low signal intensity on T1WI (Figure 10a). On T2WI, a prominently heteroge- neous mass that contains hypointense calcifi- cations or fibrosis, isointense solid component, and hyperintense (Figure 10b) hemorrhagic or necrosis areas are observed. These three differ- ent intensity findings compose the triple sign. Moreover, fluid–fluid levels secondary to hem- orrhagic areas and adjacent bone or soft tissue invasion can be seen. Dynamic gadolinium-en- hanced MRI shows an arterial phase enhance- ment as a result of the malignant features. Also,

Eur J Rheumatol 2015 Turan et al. Radiology of synovial disease

Figure 6. a-c. 25-year-old woman with diffuse pigmented villonodular synovitis (PVNS) of the knee; lateral radiograph (a) shows soft tissue swelling in the left knee. Sagittal GRE image (b) reveals an extensive suprapatellar effusion and diffuse synovial thickening with hypointense blooming arti- facts. Axial post-contrast fat-saturated T1WI(c) displays enhancing villonodular synovial fronds (from the courtesy of Dr. A. Turan)

a b c

Figure 7. a, b. 29-year-old man with localized intraarticular PVNS; sagittal GRE image(a) shows a nodular lesion with millimetric blooming artifacts of hemosiderin in suprapatellar bursa. Axi- al post-contrast fat-saturated T1WI (b) displays a marked enhancement of the lesion (from the courtesy of Dr. A. Turan)

a b

postcontrast images provide a distinction from cysts and hematomas by showing the enhanc- ing solid compenent (3, 27) (Figure 10c).

Standardized uptake values (SUV) higher than 4.4 on the positron emission tomography (PET CT) is an evidence of higher cellularity, mitotic rate, and poor prognosis (27).

Following the lungs, the lymph nodes, liver, and brain are the other common locations for metastasis. A long-term follow-up is required because 50% of deaths occur within 5–10 years after diagnosis. Both early and late me- tastases are more frequent than any other sar- comas (27).

Eur J Rheumatol 2015Turan et al. Radiology of synovial disease

Figure 8. 40-year-old woman with a giant cell tumor of the tendon sheath in the volar aspect of the second finger of left hand; axial post-contrast fat-saturated T1WI shows an enhancing lesion that nearly surrounds the flexor tendon (from the courtesy of Dr. A. Turan)

Figure 9. a-c. 53-year-old man with synovial osteochondromatosis of the knee; lateral radiograph (a) shows intraarticular calcification with a ring- and-arc shape appearance. Sagittal proton-density SPAIR image (b) displays hyperintense intraarticular osteochondral bodies. On GRE image (c), some of these bodies contain hypointense areas that indicate calcification (from the courtesy of Dr. A. Turan)

a b c

Figure 10. a-c. 49-year-old man with synovial sarcoma of antecubital fossa; Axial T1WI (a) shows isointense soft tissue tumor adjacent to the muscle (asterisk). Axial T2WI (b) reveals a hyperintense mass. Coronal post-contrast fat-saturated T1WI (c) displays a marked enhancement of the lesion (from the courtesy of Dr. A. Turan)

a b c

Surgical resection combined with radiothera- py and chemotherapy is an effective treatment methods. Imaging is useful in follow-up and assessing the response to the treatment (27).

Hemophilic arthropathy Hemophilia is an X-linked autosomal recessive- ly inherited disease; however, approximately one-third of all cases are associated with spon- taneous mutations. The prevalence of the dis- ease is 1 in 10,000 males. The level of clotting factors determines the severity of the bleed- ing. The most common sites of hemorrhage are joints, particularly the knees, ankles, and elbows. Hemorrhage may occur spontaneous- ly or as a result of trauma. Recurrent hemar- throsis causes hemosiderin deposition and synovial hypertrophy, which results in cartilage destruction and degenerative changes in the bones, ligaments, and joint capsules. The early detection of disease has a critical importance because the replacement of deficient factors prevents hemorrhage (29, 30).

Radiography only shows the late bone alter- ations such as osteopenia, overgrowth of the epiphysis, erosions, squaring of the patella, widening of the intercondylar notch, subchon- dral cysts, and joint space narrowing and con- tracture (29).

US easily detects joint effusions and synovitis, whereas cartilage damage could not be rec- ognized. Hemarthrosis can appear in different echogenicities according to the age of bleed- ing (1, 3, 29).

MRI not only detects the early soft tissue find- ings but also evaluates the bone changes and cartilage damage. T1WI reveals structural bone deformity, and fat-saturated T2WI displays

bone marrow edema. Intraarticular hemosid- erin appears as blooming artifacts on GRE im- ages (1, 3, 29) (Figure 11). The use of a contrast agent for the demonstration of synovitis is not recommended because the deposition of he- mosiderin restricts the visualization of the en- hancement (29).

Synovial vascular malformation Vascular malformations (VMs) are classified as capillary, venous, arterial, lymphatic, or mixed form. VMs involving the synovium are pres- ent at birth and grow slowly. Synovial VMs are generally encountered in children and young adults presenting with pain and swelling. The knee is the most commonly affected joint. In addition, the elbows, wrists, and ankles can be affected as well (16, 31).

Radiography shows nonspecific soft tissue swelling accompanied by phlebolithis and os- teoporosis. US reveals a heterogeneous lesion containing vascular channels (31).

MRI is the most useful modality in which sy- novial VMs appear hypointense on T1WI and hyperintense on T2WI (Figure 12a). High-flow vessels within the lesion are seen as flow void tubular structures on T2WI. The contrast en- hancement pattern differs according to the type of vascular content of the malformation. For instance, although the venous compo- nent shows homogenous intense enhance- ment (Figure 12b), lymphatic areas have a cystic nature, tending to enhance peripher- ally (31).

Lipoma arborescens Lipoma arborescens (LA) is a rare, idiopathic, intra/extraarticular disorder. LA can affect any joint, with knee joints being the most com- mon. Villous lipomatous proliferation of the synovium is typical (3, 32).

Radiography is generally nonspecific with de- generative alterations (Figure 13a). MRI exhib- its a synovial proliferation and frond-like fatty content, which is similar to subcutaneous fat on all sequences and shows a suppression on fat-saturated images (1,3) (Figure 13b, c).

Reactive synovitis Synovitis has primary or secondary causes. The term for secondary causes of synovitis is reac- tive synovitis (RS). RS develops as result of joint pathology such as trauma, foreign body, bone infarction, osteochondrondritis dissecans, and bone tumor of the epiphysis, i.e., juxtaarticular osteoid osteoma. Imaging findings include pri- mary lesions with concomitant synovitis and joint effusion (1) (Figure 14a, b).

Eur J Rheumatol 2015 Turan et al. Radiology of synovial disease

Figure 11. 15-year-old boy with hemophilic arthropathy; sagittal GRE image of the left elbow displays blooming artifacts of hemo- siderin deposition within the joint and slight joint effusion with synovitis (from the courte- sy of Dr. A. Turan)

Figure 12. a, b. 29-year-old man with synovial venous malformation; sagittal proton-density SPAIR image (a) demonstrates a hyperintense tubular structured lesion in Hoffa fat pad. Axial post-contrast fat-saturated T1WI (b) displays a contrast enhancement of the lesion (from the courtesy of Dr. A. Turan)

a b

Conclusion Synovitis is one of the most common clinical

scenarios in daily practice of rheumatologists

with diverse differential diagnosis. Although

a clinical assessment is generally adequate

for diagnosis, US and gadolinium-enhanced

MRI are helpful imaging modalities for the diagnosis and follow-up of synovial diseas- es. Radiography and DECT can contribute as well in some particular diseases. Definitive diagnosis by imaging alone is generally not possible, except in some specific conditions. However, imaging modalities provide infor-

mation on synovial proliferation and accom- panying findings that guides the clinician in differential diagnosis.

Peer-review: Externally peer-reviewed.

Author Contributions: Concept - A.T.; Design - A.T., P.Ç.; Supervision - A.T.; Materials - A.T.; Data Collection and/or Processing - A.T., P.Ç.; Analysis and/or Inter- pretation - A.T.; Literature Review -A.T.; Writer - A.T., P.Ç.; Critical Review - A.T., M.A.Ö.

Conflict of Interest: No conflict of interest was de- clared by the authors.

Financial Disclosure: The author declared that this study has received no financial support.

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Eur J Rheumatol 2015Turan et al. Radiology of synovial disease

Figure 13. a-c. 55-year-old woman with lipoma arborescens of the knee; radiography (a) demonstrates degenerative osteoarthritis of the right knee. Coronal T1WI (b) reveals frond-like fatty content, and axial post-contrast fat-saturated T1WI (c) displays enhancing synovial proliferation (from the courtesy of Dr. A. Turan)

a b c

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