Anatomy and Function of the Skin: Layers, Accessory Structures, and Pigmentation, Exercises of Anatomy

Download Anatomy and Function of the Skin: Layers, Accessory Structures, and Pigmentation and more Exercises Anatomy in PDF only on Docsity! 35 CHAPTER Overview CHAPTER SUMMARY Skin, the largest organ in the body, forms the integumentary system in conjunc- tion with its accessory structures. The skin consists of two layers: the epidermis, which includes the outer protective stratum of keratinized epithelial cells, and the dermis, the underlying layer of connective tissue containing blood vessels and nerve endings. The accessory structures include outgrowths of the epidermis (hair and nails). Hair is based in a follicle, which is found in the dermis. Sweat glands and sebum-producing glands are also based in the dermis, releasing their secre- tions onto the skin surface or into hair follicles via ducts. The skin is not just an “envelope” separating our body from the environment. The integumentary system is important in thermoregulation, protection against infection, protection against dehydration, and sensation. These roles are accomplished, in part, by the physical structure of the skin (the epidermal layer is virtually impermeable), but acces- sory structures are also involved. For instance, eccrine sweat glands are critical for cooling, and sebum renders skin more water-resistant. Skin and the accessory structures are capable of regeneration, providing that at least some actively divid- ing cells (for instance, in the nail bed or the stratum germinativum) are unharmed. This chapter does not contain any difficult concepts, but it does contain a large amount of information. Try to get students to integrate the material to the greatest extent possible, using summary tables, concept maps (see the Study Guide), and perhaps case studies. 5 The Integumentary System Memmler_SFHB_IM_Chap05.indd 35 2/13/2012 8:26:12 PM 36 Unit I The Body as a Whole UPDATES FROM THE PRIOR EDITION Significant changes to this edition include the following: 1. The dermal papillae and the labels of Figure 5-1 (skin) have been altered. 2. Typos in the labels of Figures 5-2 and 5-3 have been corrected. GENERAL RESOURCES 1. This introductory video discusses skin anatomy, function, and some of the cultural aspects of skin and its decorations. • Skin, 2002. Films for the Humanities and Sciences. ISBN 978-1-61616-525-3 (56 minutes). 2. This article in National Geographic has exceptional images and authoritative, engaging text about the amazing powers of skin. • Swerdlow JL. Unmasking skin. National Geographic 2002(November);202:36–63. 3. Online dermatology textbooks provide information about all of the topics discussed in this chapter. • Drugge R. Electronic Textbook of Dermatology, 2010. Available at: http://www.telemedicine.org/stamford.htm • John Hopkins University. Online Dermatology Atlas, 2010. Available at: http://www.dermatlas.org/ Learning Outcomes and Teaching Tools 1 NAME AND DESCRIBE THE LAYERS OF THE SKIN. The layers of the skin are illustrated in diagrammatic form (Fig. 5-1) and in a photomicrograph (Fig. 5-2) and summarized in the Web Chart on thePoint. The thickness of the epidermis and der- mis varies in different body areas (Box 5-1). The outermost protective portion of the skin is the epidermis, which contains several layers (strata) of epithelial cells (Fig. 5-1; Chapter 4) Only the cells in the bottom layer (stratum basale or germinativum) divide. Epidermal cells become progressively flatter and keratin-filled (Fig. 5-3) and eventually die as they are pushed into the outer layer (the stratum corneum). The epidermis also contains melanocytes, which synthesize pigment (melanin) and transfer it to the epithelial cells. Melanin protects cells against ultraviolet radiation from the sun. The thickness of the epidermis can be observed in some blisters (the accumulation of fluid between epidermal layers or at the epidermal–dermal boundary). Blisters result when the epidermis detaches from the dermis (or epidermal layers separate) as a result of excess heat or shearing. The dermis contains dense, fibrous, elastic connective tissue ( Chapter 4), blood vessels, nerves, and accessory organs (sweat glands, oil glands, hair follicles). The dermis also contains nerve endings involved in the detection of physical sensations (light touch, deep pressure, tem- perature, pain). Components of the connective tissue (collagen, elastin, and other components of the matrix) are synthesized by fibroblasts within the dermis. The uppermost portion of the dermis is thrown into folds (dermal papillae; Fig. 5-1) that appear as ridges on the surface of the skin. Because the pattern of ridges is genetically determined and unique to each individual, fingerprints and footprints can be used for identification. The dermal papillae also prevent the epidermis from Memmler_SFHB_IM_Chap05.indd 36 2/13/2012 8:26:14 PM Chapter 5 The Integumentary System 39 • Sensation: The skin contains free nerve endings, which detect pain and temperature changes, Meissner corpuscles, which respond to light touch, and Pacinian corpuscles, which detect deep pressure ( Chapter 10). Teaching Tools Ask students to add these functions to the table prepared for Outcome 3. For instance, “ther- moregulation” could be mentioned for the eccrine sweat glands. The delivery of some medications through the skin (transdermal patches) is discussed in Box 5-2 and in the article listed below. • Langer R. Where a pill won’t reach. Sci Am 2003(April);288:50–57. Mucosal membranes ( Chapter 4) do not have a thick epithelial layer and are subject to many more infections than regular skin. For instance, mouth ulcers (cold sores) are much more common than skin ulcers. The epithelial layer is thus critical for immune defense. The skin contains an important population of harmless and beneficial microbes . These microbes help prevent harmful microbes from colonizing the skin. Some cosmetics may harm the resident flora, and thereby enhance susceptibility to disease. Perhaps “probiotic cosmetics” might be a future trend—students can do a Web site search for this phrase and check for developments. Since skin can initiate vitamin D production under the influence of ultraviolet light, some con- sider the skin to be the largest endocrine gland in the body. A bikini-clad woman with white skin sunbathing in the summer sun can generate 10,000 IU of vitamin D in about 15 minutes, a higher dose than that found in many multivitamin supplements! The low levels of UV light in wintry climes can cause vitamin D deficiency, especially in sunscreen users and individuals with darker skin. Recent studies have linked vitamin D deficiency to cancers and autoimmune diseases. See the article below for more information. • Tavera-Mendoza LE, White JH. Cell defenses and the sunshine vitamin. Sci Am 2007(November);62–72. The movie listed below discusses how the structure and function of skin has changed over the course of evolution. • Evolve: Skin. Films for the Humanities and Sciences. 2008. Item #BVL42672 (ISBN not avail- able) (45 minutes). 5 DISCUSS THE FACTORS THAT CONTRIBUTE TO SKIN COLOR. • The pigment melanin contributes a brownish coloration to skin. Melanin levels are determined genetically and by ultraviolet light exposure. Hemoglobin in blood cells usually contributes a reddish coloration, especially when blood flow is high. The vegetable pigment carotene contrib- utes a yellow-orange color. Teaching Tools Whenever possible, ask students to link changes in skin appearance with changes in skin. It is often thought that darker pigmentation (more melanin) has evolved to protect humans from skin cancer. However, since skin cancer occurs later in life (usually post-reproductive age), Memmler_SFHB_IM_Chap05.indd 39 2/13/2012 8:26:16 PM 40 Unit I The Body as a Whole it cannot exert much evolutionary pressure. Moreover, increased pigmentation decreases vitamin D synthesis, as discussed in Outcome 4. The possibility that melanin has evolved to protect body stores of folate from ultraviolet-induced degradation is discussed in the article below. • Jablonski NG, Chaplin G. Skin deep. Sci Am 2002(October);287:74–81. The response of skin to ultraviolet radiation involves multiple stages. First, existing melanin is redistributed to the superficial side of the cell. This rapid effect explains why individuals can appear to “tan” very rapidly. Second, melanocyte activity is increased. Third, repeated exposure to UV radiation can result in increased numbers of melanocytes. 6 USING INFORMATION IN THE CASE STUDY AND TEXT, DESCRIBE THE SPECIFIC LAYER OF THE INTEGUMENTARY SYSTEM THAT WAS SUN-DAMAGED. Ultraviolet light damages the epidermis. The article and movie below discuss the historical development of the theory linking skin can- cer and sunlight. • Brash L. Sunlight and skin cancer. Sci Am. 1996(July);52–59. • Skin Cancer. Films for the Humanities and Sciences. ISBN 978-1-61616-384-6. (24 minutes). 7 SHOW HOW WORD PARTS ARE USED TO BUILD WORDS RELATED TO THE INTEGUMENTARY SYSTEM. Word parts applicable to this and other chapters are listed in the Word Anatomy chart. Learning these word parts will help students memorize terms relevant to the anatomy of skin and the accessory structures. Memmler_SFHB_IM_Chap05.indd 40 2/13/2012 8:26:17 PM