9. Biochemistry I – Contractility., Study notes of Medicine

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3/10/25, 7:33 PM about:blank 9. Biochemistry | — Contractility Biochemistry I - Contractility = Revise (of refer to the Foundation System) the actions of myosin, actin, troponin ‘and tropomyosin - Define winy calcium is essential for contraction - Identify the different types of muscle histology with regards to the CVS system - Define what is meant by a myocyte, sarcomeres, troponin, ATP including each of their relevant functions - Define Starlings law and illustrate its importance in the CVS system = Ilustrate and recall the process of how the cellular and molecular events underlying cardiac contraction and relaxation occur - Define the very basic role of Na, K and Ca homeostasis in maintaining cardiac contractility ‘Stmicture of the heart Epon Sats - There are four cardiac chambers within the heart that is built upon a ring of fibrous tissue which is located at the ATRIO-VENTRICULAR JUNCTION ‘©. This is called the ANNULUS FIBROSIS ‘© Ithas an important role in electrically insulating the atria from the ventricles ‘©. This would then allow ATRIAL SYSTOLE to occur where there would be ‘emptying of the blood in the atria into the ventricle © This could happen without contraction of ventricles as excitation ‘wave is not spread due to the annulus fibrosis, - The heart would consist of © ENDOCARDIUM composed of endothelial cells © MYOCARDIUM — composed of specialised muscle cells called MYOCYTES ‘© EPICARDIUM — composed of a thin layer of mesothelial cells as well as the connective tissue © PERICARDIUM ~ a fibrous sac that would enclose the heart 4/15