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A comprehensive set of questions and answers related to urinalysis and body fluids, covering key aspects of renal anatomy, nephron function, and urine examination. It includes topics such as glomerular filtration, tubular reabsorption, urine concentration, and the chemical examination of urine, making it a valuable resource for students studying clinical laboratory science or related fields. The material covers urine color, appearance, odor, specific gravity, and the clinical significance of various analytes found in urine, such as ph, glucose, protein, ketones, nitrite, leukocyte esterase, bilirubin, urobilinogen, and hemoglobin. It also addresses microscopic examination of urine, including the identification of cells, casts, and crystals.
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What consists of the gross renal anatomy? - Correct Answer-Kidneys, Ureters, Bladder, and Urethra What is the anatomy of the Nephron? - Correct Answer-Glomerulus. proximal convoluted tubule, descending Loop of Henle, Ascending Loop of Henle, distal convoluted tubule, and collecting duct. What are the 3 primary functions of the kidneys? - Correct Answer-Glomerulur Filtration, Tubular Reabsorption, and Tubular Secretion True or False: Cells are filtered through the glomerulus? - Correct Answer-False What is the GFR? - Correct Answer-Volume of blood filtered per minute. What does the glomerulus filter? - Correct Answer-The Blood The fluid that is filtered from the blood in the glomerulus travels to where? - Correct Answer-The nephron The proximal convoluted tubule reabsorbs what? - Correct Answer-Sodium, Potassium, Bicarbonate, and Water. The proximal convoluted tubule secretes what? - Correct Answer-Hydrogen Ions, Urea, Creatinine, and Uric Acid. What is the primary function of the Loop of Henle? - Correct Answer-To reabsorb water, sodium, and chloride. What is the function of aldosterone in the Distal Convoluted Tubule? - Correct Answer- To increase Sodium re-absorption. Where is aldosterone produced? - Correct Answer-In the adrenal cortex Where is the final site for urine concentration? - Correct Answer-Collecting Duct What is the function of antidiuretic hormone? - Correct Answer-To act on the collecting ducts and stimulate water reabsorption. Where is antidiuretic hormone stored? - Correct Answer-The Posterior Pituitary
What is produced by the kidney? - Correct Answer-Renin, Prostaglandins, and Erythropoietin. The kidney is the target tissue for what? - Correct Answer-Aldosterone and Antidiuretic Hormone What is the most preferred urine collected? - Correct Answer-First morning specimen What is the most common urine specimens? - Correct Answer-Random Specimens First morning urine specimens must be examined when? - Correct Answer-Within 1 hour of collection What happens to a urine sample after one hour? - Correct Answer-The bacteria multiplies, false positives for Nitrate, pH becomes alkaline, casts disintegrate, and red cells are lysed. The physical examination of urine includes? - Correct Answer-Color, appearance, odor, and specific gravity. Urine color, correlates with what? - Correct Answer-Concentration Dark yellow urine is ___________________? - Correct Answer-Concentrated Light yellow urine is _______________? - Correct Answer-Diluted What makes urine yellow? - Correct Answer-Urochrome What causes a dark yellow/amber/orange color in urine? - Correct Answer- Concentration, bilirubin, and pyridium What causes urine to be red in color? - Correct Answer-Hemoglobin and red blood cells. What causes urine to be blackish brown? - Correct Answer-Homogentistic Acid Urine appearance may be reported? - Correct Answer-Clear, Hazy, Cloudy, or Turbid What are common causes of hazy, cloudy, or turbid urine specimens? - Correct Answer-Bacteria, hematuria, mucus, or amorphous crystals. A freshly voided urine should have what type of odor? - Correct Answer-Aromatic Oder A patient with diabetes mellitus may have a urine with what type of odor? - Correct Answer-Fruity Odor
What analytes are commonly examined during the chemical examination of urine? - Correct Answer-pH, Glucose, Protein, Ketones, Nitrite, Leukocyte esterase, Bilirubin, Urobilinogen, and Hemoglobin. What is the normal pH range for urine? - Correct Answer-4.5-8.0 pH What is the principle for the urine pH strip test? - Correct Answer-Double indicator system What is the renal threshold for glucose? - Correct Answer-160-180 mg/dL Does normal urine contain glucose? - Correct Answer-No Glucose is often present in the urine of patients with? - Correct Answer-Diabetes mellitus What is the principle for the urine glucose strip test? - Correct Answer-Double enzymatic reaction What enzymes are in the glucose strip test for urine? - Correct Answer-Peroxidase and Glucose oxidase Clinitest should be performed on who? - Correct Answer-Newborns Why should Clinitest be used in a routine analyses of a newborn's urine? - Correct Answer-Because it can detect galactose (as well as other sugars) What are ketones? - Correct Answer-The breakdown products of lipids. Ketones are normally ___________ in urine. - Correct Answer-Absent Ketones may appear in the urine due to? - Correct Answer-Weight loss, Starvation, and diabetes mellitus What is the principle of the reagent strip test for urine Ketones? - Correct Answer- Sodium Nitroprusside Reaction What does the protein reagent strip measure in urine? - Correct Answer-Albumin True or False: Normal urine is free of proteins. - Correct Answer-True What can cause a false positive for proteins in urine? - Correct Answer-An alkaline pH What test method is used to confirm the presence of protein in urine? - Correct Answer- Sulfosalicyclic Acid
What is the principle behind the urine protein reagent strip test? - Correct Answer- Protein error of indicators A Gram-negative bacillus (e.g. E. coli) can reduce nitrate to what? - Correct Answer- Nitrite True or False: Gram-positive bacillus (Staphyl, Strep, Entero) is unable to reduce nitrate to nitrite. - Correct Answer-True What is the principle for the reagent strip test for Nitrite? - Correct Answer-Griess's Reaction What can cause false negatives in the reagent strip test for urine nitrite? - Correct Answer-Inadequate incubation of urine in bladder A positive esterase urine test indicates? - Correct Answer-White Blood cells in the urine When are WBCs typically seen in urine? - Correct Answer-During an infection A purple color in the urine esterase test is? - Correct Answer-Positive (WBCs present) What is Bilirubin? - Correct Answer-A breakdown product of hemoglobin degradation. Is urine bilirubin present in pre-hepatic jaundice? - Correct Answer-No Increased amounts of urobilinogen occurs during? - Correct Answer-Pre-hepatic Jaundice Urine bilirubin and urobilinogen increases during what disease state - Correct Answer- Hepatic Jaundice What is an example of post hepatic jaundice? - Correct Answer-Bile duct obstruction Increased urine bilirubin and normal urobilinogen levels indicate? - Correct Answer-Post hepatic Juandice What is the principle for the urine bilirubin reagent strip test? - Correct Answer-The Diazo Reaction What is urine bilirubin broken down to? - Correct Answer-Urobilinogen Where is Uroblininogen produced? - Correct Answer-The intestines (bacteria breaks down Bilirubin)
Clue cells are indicative of? - Correct Answer-G. vaginalis Urine with may epithelial cells is considered to be? - Correct Answer-Contaminated An increased amount of transitional epithelial cells indicates? - Correct Answer-An invasive urological procedure (catheter specimen) A small amount of transitional epithelial cells in the urine is considered to be? - Correct Answer-Normal Transitional epithelial cells originated from? - Correct Answer-Lining cells for the renal pelvis, ureters, bladder, and upper portion of urethra. Renal tubular epithelial cells are almost ___________ clinically significant. - Correct Answer-Always Where do the Renal tubular epithelial cells originate from? - Correct Answer-Proximal and Distal convoluted tubules. What is the cause of renal tubular epithelial cells in urine? - Correct Answer-Tubular necrosis, acute pyelonephritis, rejection of a transplant, and acute glomerulonephritis. When are oval fat bodies observed in urine? - Correct Answer-Nephrotic syndrome Describe the appearance of oval fat bodies? - Correct Answer-Highly retractile RTE cells contain fat and form maltese cross under polarized light. When is bacteria in urine clinically significant? - Correct Answer-In the presence of WBCs (indicating an infection) What fungi can be present in urine? - Correct Answer-Budding yeast and branching mycelium. Patients with diabetes mellitus and vaginal yeast infections may have what in their urine? - Correct Answer-Budding yeast cells or mycelium What are four parasites found in the urine? - Correct Answer-Trichomonas vaginalis, Enterobius vermicularis, Strongyloides stercoralis, and Schistosoma haematobium. This urine parasite has a pear shaped flagellate? - Correct Answer-Trichomonas vaginalis This urine parasite has a bread shaped ova and results from fecal contamination? - Correct Answer-Enterobius vermicularis
This rhabdiform larvae appears in urine contaminated with feces? - Correct Answer- Strongyloides stercoralis This urine parasite is commonly known as a blood fluke? - Correct Answer-Schistosoma haematobium If urine has casts in it, the protein test should be? - Correct Answer-Positive Red blood cell's casts appear in the urine during? - Correct Answer-Acute Glomerulonephritis and strenuous exercise A urine with Red blood cell casts should be positive for? - Correct Answer-Protein and occult blood What infection would cause white blood cell casts to appear in the urine? - Correct Answer-Acute pyelonephritis and acute interstitial nephritis When WBC casts are noted in the urine, what other tests should be positive? - Correct Answer-Protein and esterase Bacterial casts in urine occur in patients with? - Correct Answer-Pyelonephritis If bacterial casts are noted in the urine, what other tests should be positive? - Correct Answer-Protein and nitrite When can granular casts be seen in the urine? - Correct Answer-Stress, strenuous exercise, acute glomerulonephritis, and pyelonephritis Why are waxy casts clinically significant? - Correct Answer-Because the urine stopped flowing in the nephrons, chronic glomerulonephritis, and chronic renal failure. When are fatty casts noted in the urine? - Correct Answer-Nephrotic syndrome and Tubular necrosis Fatty casts should correlate with what other urine test? - Correct Answer-Positive protein test and oval fat bodies. Broad casts are seen in the urine of what conditions? - Correct Answer-Chronic renal failure and chronic glomerulonephritis Broad casts in the urine should correlate with what other urine tests? - Correct Answer- Positive protein test and waxy casts. What three crystals are normally found in the acid urine? - Correct Answer-Uric acid crystals, Amorphous urate crystals, and Calcium oxalate crystals.
Urine cholesterol crystals are caused by? - Correct Answer-lipiduria and nephrotic syndrome These urine crystals appear as fine, colorless needle forming rosettes? - Correct Answer-Tyrosine crystals What is the cause of urine tyrosine crystals? - Correct Answer-Tyrosinuria These urine crystals appear as colorless concentric circles with radial striations? - Correct Answer-Leucine crystals What are the cause of urine leucine crystals? - Correct Answer-Maple syrup disease What are the chemical findings in acute pyelonephritis? - Correct Answer-Positive protein, nitrite, and leukocyte esterase. What are the microscopic findings in acute pyelonephritis? - Correct Answer-WBCs, WBC casts, bacteria, and RBCs. What are the chemical findings for acute glomerulonephritis? - Correct Answer-Positive for protein, blood, and an increased specific gravity. What are the microscopic findings for acute glomerulonephritis? - Correct Answer- RBCs, WBCs, RBC casts, and granular casts.