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Revision:06/14/
Acetaminophen
SAFETY DATA SHEET
Supersedes Revision: 09/14/ according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/
1.1 Product Code: 22629
Section 1. Identification of the Substance/Mixture and of the Company/Undertaking
Product Name: Acetaminophen
Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Ann Arbor, MI 48108
Emergency Contact: CHEMTREC Within USA and Canada: +1 (800)424- CHEMTREC Outside USA and Canada: +1 (703)527-
Information: Cayman Chemical Company +1 (734)971-
Relevant identified uses: For research use only, not for human or veterinary use.
Web site address: www.caymanchem.com
N-(4-hydroxyphenyl)-acetamide; Paracetamol; 4'-Hydroxyacetanilide; NSC 109028; NSC 3991; APAP; 4-Acetamidophenol;
Synonyms:
1.3 Details of the Supplier of the Safety Data Sheet:
1.2 Relevant identified uses of the substance or mixture and uses advised against:
1.4 Emergency telephone number:
Section 2. Hazards Identification
Acute Toxicity: Oral, Category 4 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Skin Sensitization, Category 1B Specific Target Organ Toxicity (single exposure), Category 3 Aquatic Toxicity (Acute), Category 2 Aquatic Toxicity (Chronic), Category 2
2.1 Classification of the Substance or Mixture:
H302: Harmful if swallowed. H315: Causes skin irritation. H317: May cause an allergic skin reaction. H319: Causes serious eye irritation. H335: May cause respiratory irritation. H401: Toxic to aquatic life. H411: Toxic to aquatic life with long lasting effects.
GHS Hazard Phrases:
2.2 Label Elements:
GHS Signal Word: Warning
Revision:06/14/
Acetaminophen
SAFETY DATA SHEET
Supersedes Revision: 09/14/
P261: Avoid breathing {dust/fume/gas/mist/vapors/spray}. P264: Wash {hands} thoroughly after handling. P272: Contaminated work clothing should not be allowed out of the workplace. P273: Avoid release to the environment. P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
GHS Precaution Phrases:
P301+312: IF SWALLOWED: P312: Call a POISON CENTER or doctor/physician if you feel unwell. P302+352: IF ON SKIN: Wash with plenty of soap and water. P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P321: Specific treatment {see ... on this label}. P330: Rinse mouth. P332+313: If skin irritation occurs, get medical advice/attention. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P337+313: If eye irritation persists, get medical advice/attention. P362+364: Take off contaminated clothing and wash it before reuse. P391: Collect spillage.
GHS Response Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.
GHS Storage and Disposal Phrases:
2.3 Causes serious eye irritation. Causes skin irritation. Causes damage to organs through prolonged or repeated exposure. Harmful if swallowed. Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause an allergic skin reaction. May cause respiratory system irritation. Toxic to aquatic life with long lasting effects. To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
Adverse Human Health Effects and Symptoms:
CAS # /
RTECS
Hazardous Components (Chemical Name)/ REACH Registration No.
Section 3. Composition/Information on Ingredients
Concentration EC No./ EC Index No.
GHS Classification
103-90- AE
4-Acetamidophenol 100.0 % 203-157- NA
Acute Tox.(O) 4: H Skin Corr. 2: H Skin Sens. 1B: H Eye Damage 2: H STOT (SE) 3: H335 H Aquatic (A) 2: H Aquatic (C) 2: H
Revision:06/14/
Acetaminophen
SAFETY DATA SHEET
Supersedes Revision: 09/14/
Respiratory Equipment^ NIOSH approved respirator, as conditions warrant. (Specify Type):
Eye Protection: Safety glasses Protective Gloves: Compatible chemical-resistant gloves Other Protective Clothing: Lab coat
Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits.
Engineering Controls (Ventilation etc.):
Do not take internally. Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower. Wash thoroughly after handling.
Work/Hygienic/Maintenan ce Practices:
No data available.
8.2 Exposure Controls:
8.2.2 Personal protection equipment:
Section 9. Physical and Chemical Properties
Physical States: [ ] Gas [ ] Liquid [ X ] Solid
Melting Point: No data. Boiling Point: No data. Flash Pt: No data.
Explosive Limits: LEL: No data. UEL: No data. Vapor Pressure (vs. Air or mm Hg):
No data.
Vapor Density (vs. Air = 1): No data.
Evaporation Rate: No data.
pH: No data.
Appearance and Odor: A crystalline solid
9.1 Information on Basic Physical and Chemical Properties
Flammability (solid, gas): No data available.
Specific Gravity (Water = 1): No data. Solubility in Water: No data. Solubility Notes: ~2 mg/ml in PBS (pH 7.2); ~25 mg/ml in EtOH & DMF; ~20 mg/ml in DMSO; Octanol/Water Partition Coefficient:
No data.
Decomposition Temperature: No data.
Autoignition Pt: No data.
Viscosity: No data.
Percent Volatile: No data.
9.2 Other Information
Molecular Formula & Weight: C8H9NO2 151.
Revision:06/14/
Acetaminophen
SAFETY DATA SHEET
Supersedes Revision: 09/14/
Section 10. Stability and Reactivity
Conditions To Avoid: No data available.
Stability: Unstable [ ] Stable [ X ]
Incompatibility - Materials strong oxidizing agents To Avoid: carbon dioxide carbon monoxide nitrogen oxides
Hazardous Decomposition or Byproducts:
Polymerization:^ Will occur [^ ]^ Will not occur [ X ]
Stability Note(s): Stable if stored in accordance with information listed on the product insert.
Reactivity: No data available.
CAS # Hazardous Components (Chemical Name) NTP
Section 11. Toxicological Information
The toxicological effects of this product have not been thoroughly studied. Acetaminophen - Toxicity Data: Oral LD50 (rat): 1944 mg/kg; Intraperitoneal LD50 (rat): 1205 mg/kg; Oral LD50 (mouse): 338 mg/kg; Intraperitoneal LD50 (mouse): 367 mg/kg; Oral TDLO (woman): 325 mg/kg; Oral LDLO (human): 143 mg/kg;
Information on Toxicological Effects:
Acetaminophen - Investigated as a drug, mutagen, reproductive effector, and tumorigen. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information. Acetaminophen RTECS Number: AE
Chronic Toxicological Effects:
IARC ACGIH OSHA
103-90-2 4-Acetamidophenol n.a. 3 n.a. n.a.
Avoid release into the environment. Runoff from fire control or dilution water may cause pollution.
Toxicity:
Section 12. Ecological Information
Persistence and No data available. Degradability: Bioaccumulative No data available. Potential: Mobility in Soil: No data available. Results of PBT and vPvB No data available. assessment: 12.6 Other adverse effects: No data available.
13.1 Waste Disposal Method: Dispose in accordance with local, state, and federal regulations.
Section 13. Disposal Considerations
