Antiviral Therapy - Microbiology - Lecture Slides, Slides of Microbiology

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Antiviral Therapy

Antiviral Therapy

• Antiviral chemotherapy
• Interferon
• Gene therapy
• Chinese Herbs

Targets for chemotherapeutic agents

• Attachment to host cell
• Uncoating – (amantadine)
• Synthesis of viral mRNA-(interferon)
• Translation of mRNA-(interferon)
• Replication of viral RNA or DNA- (nucleoside anologues)
• Maturation of new virus proteins-(protease inhibitors)
• Budding , release

Diseases for which effective therapy is

available

• AIDS:

Zidovudine叠氮胸苷+ Lamivudine拉米夫定+ protease inhibitors

• Influenza: Amantadine
• Herpes simplex virus: Acyclovir
• Varicella-Zoster virus: Acyclovir
• Cytomegalovirus : Gancyclovir更昔洛韦, Foscarnet膦甲 酸
• Respiratory syncitial virus: Ribavirin利巴韦林

Interferon

• Direct antiviral effect ( prevents the infection of

new cells) by a) degradation of viral mRNA, and b)

inhibition of protein synthesis

• Enhancement of the specofic immuneresponse

by increasing the expression of MHC class I

molecules on the surface of infected cells, the

interferons increase the opportunity for specifif

cytotoxic T cells to recognise and kill infected cells

• Chronic hepatitis B and C virus