Homework๎on๎Repeated๎Measures๎
A๎researcher๎is๎interested๎in๎the๎effects๎of๎different๎therapeutic๎treatment๎methods๎and๎how๎they๎
interact๎with๎varying๎dosages๎of๎a๎drug.๎Patients๎in๎a๎study๎are๎assigned๎to๎one๎of๎four๎therapeutic๎
treatment๎methods๎(A,๎B,๎C)๎and๎are๎given๎a๎drug๎before๎each๎of๎four๎different๎office๎visits.๎The๎
dosage๎is๎varied๎across๎visits.๎In๎other๎words,๎each๎participant๎receives๎four๎different๎dosages๎of๎the๎
drug.๎However,๎the๎order๎of๎dosage๎is๎randomized๎across๎time.๎Each๎patient๎is๎measured๎on๎a๎key๎
response๎indicator๎at๎each๎office๎visit.๎๎
The๎data๎set๎doses๎contains๎the๎data๎for๎48๎patients.๎The๎following๎variables๎are๎in๎the๎data๎set:๎
Method๎๎ therapeutic๎treatment๎method๎A,๎B,๎or๎C๎
D1๎๎ response๎at๎10๎mg๎dosage๎of๎the๎drug๎๎
D2๎๎๎ response๎at๎20๎mg๎dosage๎of๎the๎drug๎
D3๎๎ response๎at๎50๎mg๎dosage๎of๎the๎drug๎
D4๎๎ response๎at๎100๎mg๎dosage๎of๎the๎drug๎
Perform multivariate repeated measures analysis on the doses data using Method as a between-
subjects variable and D1-D4 as the repeated measurements variables. Use polynomial contrasts with
the numeric values 10, 20, 50, and 100 to set the spacing for the orthogonal polynomial contrasts.
Provide a means plot, displaying the mean on the vertical axis, the dose on the horizontal axis, with
different symbols for each of the three methods. Connect the means for each method with straight
lines.
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