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ASCP CHEMISTRY COMPREHENSIVE STUDY
GUIDE 2026 FULLY SOLVED QUESTION SET
◉Photodiode array. Answer: Which component is required in a spectrophotometer in order to produce a spectral absorbance curve? ◉The range of wavelengths passed at 50% maximum transmittance. Answer: The half-band width of a monochromator is defined by: ◉The color of reagents. Answer: The reagent blank corrects for absorbance caused by: ◉100% reflectance is set with an opaque film called a white reference. Answer: Reflectometry does not follow Beers-Law but the relationship between concentration and reflectance can be described by a logistic formula. Name the statement that best describes Reflectometry? ◉Ruthenium. Answer: Which substance is used to generate the light signal in electrochemiluminescence? A. Acridinium
B. Luminol C. Dioxetane phosphate D. Ruthenium ◉Nephelometry. Answer: Measuring light scattered at 90* to the incident light for maximum sensitivity to small particles which cause cloudiness in drinking water. ◉Convert ions to atoms. Answer: The pourpose of the nebulizer in an atomic absorption spectrophotometer that uses a flame is to: ◉A graphite capillary furnace. Answer: Flameless atomic absorption uses a hollow tube of graphite with quartz ends. The tube is heated in stages by an electric current to successfully dry, ash and atomize the sample. A flameless atomic absorption spectrophotometer dehydrates and atomizes a sample using what? ◉20:1. Answer: At blood ph 7.40, what is the ratio of bicarbonate to carbonic acid? ◉7.35-7.45. Answer: The reference range for the pH of arterial blood measured at 37 degrees C is:
◉sodium. Answer: The solute that contributes the most to the total serum osmolality is: ◉whole blood specimens are acceptable. Answer: Which of the following is true about direct ion selective electrodes for electrolytes? ◉elevated lipid levels. Answer: Sodium determination by indirect ion selective electrode is falsely decreased by: ◉Na is falsely decreased by indirect ISE. Answer: A physician requested that electrolytes on a multiple myeloma patient specimen be run by direct ISE and not indirect ISE because: ◉Parathyroid hormone. Answer: Calcium concentration in the serum is regulated by: ◉parathyroid. Answer: The regulation of calcium and phosphorous metabolism is accompanied by which of the following glands? ◉Hypothyroidism. Answer: A 45-year-old female presents to her physician with chronic constipation, fatigue, and cold intolerance.
◉hyperparathyroidism. Answer: A generalized mottled appearance of the bone and partial loss of the lamina dura - loosening of teeth can also occur with ______. ◉Steatorrhea. Answer: Discharge of fat in the feces due to improper digestion and malabsorption of fat. ◉calcium. Answer: A hospitalized patient is experiencing increased neuromusclular irritability (tetany). Which of the following test should be ordered immediately? ◉magnesium. Answer: Which of the following is most likely to be ordered in addition to serum calcium to determine the cause of tetany? ◉calcium and phosphate. Answer: A reciprocal relationship exist between: A. sodium and potassium B. calcium and phosphate C. chloride and CO D. calcium and magnesium
◉ionic charge. Answer: The realative migration rate of proteins on cellulose acetate is based on: ◉cystine. Answer: Which of the following amino acids is associated with sulfhydryl group? ◉valine, leucine and isoleucine. Answer: Maple syrup urine disease is characterized by an increase in which of the following urinary amino acids? phenylalanine tyrosine valine, leucine and isoleucine cysteine and cysteine ◉dehydration. Answer: Increased serum albumin concentrations are seen in which of the following conditions? nephrotic syndrome acute hepatitis chronic inflammation dehydration ◉gamma. Answer: A patient is admitted with biliary cirrhosis. If a serum protein electrophoresis is performed, which of the following globulin fractions will be most elevated?
alpha- 1 alpha- 2 beta gamma ◉alpha-2 globulin. Answer: Which of the following serum protein fractions is most likely to be elevated in parents with nephrotic syndrome? ◉at 100 degrees C. Answer: A characteristic of the Bence-Jones protein that is used to distinguish it from other urinary proteins is it soulability ◉immunofixation. Answer: The identification of Bence-Jones protein is best accomplished by: ◉transferrin. Answer: Total iron-binding capacity measures the serum transporting capacity of: ◉separation of iron from transferring. Answer: The first step in the quantitation of serum iron is: ◉spun, separated, iced, and tested immediately. Answer: To assure accurate ammonia level result, the specimen should be:
◉GGT (Gamma-glutamyl transpeptidase). Answer: ____ diagnoses and monitors hepatobiliary disease. ◉Wheatstone bridge. Answer: What type of measuring circuit is used in a freezing point osmometer? ◉Seebeck. Answer: Which measurement principal is employed in a vapor pressure osmometer? ◉flame ionization. Answer: The most commonly used detector for clinical gas-chromatography (GLC) is based upon: ◉boiling point. Answer: In gas chromatography, the elution order of volatiles is usually based upon the: ◉Hemolytic Anemia. Answer: Which of the following is an unusual complication that may occur in infectious mononucleosis? ◉Neutropenia. Answer: An absolute decrease in the number of circulating neutrophils is defined as ___________. This condition is present in patients having neutrophil counts of less than 1.5 x 10*9/L.
◉Giant lysosomal granules. Answer: The morphological characteristic(s) associated with the Chediak-Higashi syndrome is __________. ◉A shift to the left increase in immature granulocytes. Answer: The familial condition of Pelger-Huet anomaly is important to recognize because this disorder must be differentiated from________. ◉Dohle bodies. Answer: Which inclusions may be seen in leukocytes? ◉50% - 70%. Answer: What is the typical range of relative lymphocyte percentage in the peripheral blood smear of a 1-year old child? ◉May-Hegglin anomaly. Answer: The familial disorder featuring pseudo-Dohle bodies, thrombocytopenia, and large platelets is called________ ◉G6PD Deficiency. Answer: If a patients Blood cells lyse after a drug is given what do they have? ◉Auer Rods. Answer: slender, rod-shaped bodies within the cytoplasm that are similar to azurophilic granules; seen within the
◉At least 20%. Answer: The WHO classification requires what percentage for the blast count in the bone marrow for diagnosia of AML? ◉ALL Acute Lymphoblastic Leukemia. Answer: 80% from B cells 20% T cells; primarily a children's disorder; lymphoblasts give rise to malignant proliferation ◉Acute Lymbhoblastic Leukemia. Answer: An acute form of leukemia, or cancer of the white blood cells. A patient with this form of leukemia overproduces lymphoblast in the bone marrow and causes damage by inhibiting the production of normal cells. ◉CML Chronic myelogenous leukemia. Answer: A Myeloproliferative disorder characterized by a slowly progressing blood and bone marrow disease. Too many granulocytes are abnormal and do not become healthy white blood cells. ◉Rouleaux. Answer: What is the characteristic finding seen in the peripheral smear of a patient with multiple myeloma? ◉Philidelphia chromosome. Answer: The Ph1 chromosome is a diagnostic marker for CML Osteolytic lesions, monoclonial gammopathy, and bone marrow infiltration by plasma cells constitute the triad of diagnostic markers for multiple myeloma.
◉Lymphoplasmacytoid cells. Answer: Waldenstrom's macroglobulinemia is a malignancy of the_______. ◉Tissue Factor. Answer: _______ is found on the surface of many cells outside the vascular system and indicates in vivo coagulation by activation of factor VII, ◉XII a. Answer: This clotting factor plays a role in clot formation in vitro. ◉Polycythemia. Answer: A disorder characterized by an abnormal increase in the number of red blood cells in the blood. ◉Both prolonged. Answer: What results would be expected for the prothrombin time(PT) and activated partial thromboplastin time (aPTT) in a patient with polycythemia? ◉Thromboplastin and calcium. Answer: What reagents are used in the PT test? ◉Thrombin time. Answer: Which test would be abnormal in a patient with factor X deficiency?
◉Hypersplenism. Answer: Thrombocytopenia may be associated with____. ◉Glycoprotein Ib. Answer: Normal platelet adhesion depends on_____. ◉Platelet count. Answer: A patient with classic von Willebrands disease will have a___. ◉Cyclo-oxygenase. Answer: Asprin permanently shuts down __ which inhibits thromboxane A ◉Bernard-Soulier syndrome. Answer: Patient labs show deficient GPIb-IX-V receptor and lack of platelet binding even though platelets are present. What is the name of this autosomal recessive disorder?
