ToxFAQsTM: Beryllium Exposure and Health Effects, Study notes of Toxicology

Answers to frequently asked questions (faqs) about beryllium, its properties, environmental behavior, and health effects. It covers topics such as what beryllium is, how it enters the environment, ways of exposure, health impacts, and regulatory measures.

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BERYLLIUM
CAS #7440-41-7
Division of Toxicology ToxFAQsTM September 2002
This fact sheet answers the most frequently asked health questions (FAQs) about beryllium. For more
information, call the ATSDR Information Center at 1-888-422-8737. This fact sheet is one in a series
of summaries about hazardous substances and their health effects. It is important you understand this
information because this substance may harm you. The effects of exposure to any hazardous substance
depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other
chemicals are present.
HIGHLIGHTS: People working or living near beryllium industries have the
greatest potential for exposure to beryllium. Lung damage has been observed
in people exposed to high levels of beryllium in the air. About 1-15% of all
people occupationally-exposed to beryllium in air become sensitive to beryllium
and may develop chronic beryllium disease (CBD), an irreversible and
sometimes fatal scarring of the lungs. CBD may be completely asymptomatic or
begin with coughing, chest pain, shortness of breath, weakness, and/or fatigue.
Beryllium has been found in at least 535 of the 1,613 National Priorities List
sites identified by the Environmental Protection Agency (EPA).
What is beryllium?
Beryllium is a hard, grayish metal naturally found in mineral
rocks, coal, soil, and volcanic dust. Beryllium ore is mined,
and the beryllium is purified for use in nuclear weapons and
reactors, aircraft and space vehicle structures, instruments, x-
ray machines, and mirrors. Beryllium oxide is used to make
speciality ceramics for electrical and high-technology
applications. Beryllium alloys are used in automobiles,
computers, sports equipment (golf clubs), and dental
bridges.
What happens to beryllium when it enters the
environment?
โ€˜ Beryllium dust enters the air from burning coal and oil.
This beryllium dust will eventually settle over the land and
water.
โ€˜ It enters water from erosion of rocks and soil, and from
industrial waste. Some beryllium compounds will dissolve in
water, but most stick to particles and settle to the bottom.
โ€˜ Most beryllium in soil does not dissolve in water and
remains bound to soil.
โ€˜ Beryllium does not accumulate in the food chain.
How might I be exposed to beryllium?
โ€˜ The general population is normally exposed to low levels
of beryllium in air, food, and water.
โ€˜ People working in industries where beryllium is mined,
processed, machined, or converted into metal, alloys, and
other chemicals may be exposed to high levels of beryllium.
People living near these industries may also be exposed to
higher than normal levels of beryllium in air.
โ€˜ People living near uncontrolled hazardous waste sites may
be exposed to higher than normal levels of beryllium.
How can beryllium affect my health?
Beryllium can be harmful if you breathe it. The effects
depend on how much you are exposed to, for how long, and
individual susceptibility. If beryllium air levels are high
enough (greater than 1000 ug/m3), an acute condition can
result. This condition resembles pneumonia and is called
acute beryllium disease Occupational and community air
standards are effective in preventing acute lung damage.
Some people (1-15%) become sensitive to beryllium. These
individuals may develop an inflammatory reaction in the
respiratory system. This condition is called chronic
beryllium disease (CBD), and can occur years after exposure
to higher than normal levels of beryllium (greater than 0.2
ug/m3). This disease can make you feel weak and tired, and
can cause difficulty in breathing. It can also result in
anorexia, weight loss, and may also lead to right side heart
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Public Health Service
Agency for Toxic Substances and Disease Registry
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BERYLLIUM

CAS #7440-41-

Division of Toxicology ToxFAQsTM^ September 2002

This fact sheet answers the most frequently asked health questions (FAQs) about beryllium. For more

information, call the ATSDR Information Center at 1-888-422-8737. This fact sheet is one in a series

of summaries about hazardous substances and their health effects. It is important you understand this

information because this substance may harm you. The effects of exposure to any hazardous substance

depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other

chemicals are present.

HIGHLIGHTS: People working or living near beryllium industries have the

greatest potential for exposure to beryllium. Lung damage has been observed

in people exposed to high levels of beryllium in the air. About 1-15% of all

people occupationally-exposed to beryllium in air become sensitive to beryllium

and may develop chronic beryllium disease (CBD), an irreversible and

sometimes fatal scarring of the lungs. CBD may be completely asymptomatic or

begin with coughing, chest pain, shortness of breath, weakness, and/or fatigue.

Beryllium has been found in at least 535 of the 1,613 National Priorities List

sites identified by the Environmental Protection Agency (EPA).

What is beryllium?

Beryllium is a hard, grayish metal naturally found in mineral rocks, coal, soil, and volcanic dust. Beryllium ore is mined, and the beryllium is purified for use in nuclear weapons and reactors, aircraft and space vehicle structures, instruments, x- ray machines, and mirrors. Beryllium oxide is used to make speciality ceramics for electrical and high-technology applications. Beryllium alloys are used in automobiles, computers, sports equipment (golf clubs), and dental bridges.

What happens to beryllium when it enters the

environment?

โ€˜ Beryllium dust enters the air from burning coal and oil. This beryllium dust will eventually settle over the land and water. โ€˜ It enters water from erosion of rocks and soil, and from industrial waste. Some beryllium compounds will dissolve in water, but most stick to particles and settle to the bottom. โ€˜ Most beryllium in soil does not dissolve in water and remains bound to soil. โ€˜ Beryllium does not accumulate in the food chain.

How might I be exposed to beryllium?

โ€˜ The general population is normally exposed to low levels

of beryllium in air, food, and water. โ€˜ People working in industries where beryllium is mined, processed, machined, or converted into metal, alloys, and other chemicals may be exposed to high levels of beryllium. People living near these industries may also be exposed to higher than normal levels of beryllium in air. โ€˜ People living near uncontrolled hazardous waste sites may be exposed to higher than normal levels of beryllium.

How can beryllium affect my health?

Beryllium can be harmful if you breathe it. The effects depend on how much you are exposed to, for how long, and individual susceptibility. If beryllium air levels are high enough (greater than 1000 ug/m^3 ), an acute condition can result. This condition resembles pneumonia and is called acute beryllium disease Occupational and community air standards are effective in preventing acute lung damage.

Some people (1-15%) become sensitive to beryllium. These individuals may develop an inflammatory reaction in the respiratory system. This condition is called chronic beryllium disease (CBD), and can occur years after exposure to higher than normal levels of beryllium (greater than 0. ug/m^3 ). This disease can make you feel weak and tired, and can cause difficulty in breathing. It can also result in anorexia, weight loss, and may also lead to right side heart

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Public Health Service Agency for Toxic Substances and Disease Registry

Page 2

Federal Recycling Program Printed on Recycled Paper

ToxFAQsTM^ Internet address is http://www.atsdr.cdc.gov/toxfaq.html

Where can I get more information? For more information, contact the Agency for Toxic Substances and

Disease Registry, Division of Toxicology, 1600 Clifton Road NE, Mailstop F-32, Atlanta, GA 30333. Phone: 1-888- 8737, FAX: 770-488-4178. ToxFAQs Internet address via WWW is http://www.atsdr.cdc.gov/toxfaq.html. ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.

enlargement and heart disease in advanced cases. Some people who are sensitized to beryllium may not have any symptoms. The general population is unlikely to develop chronic beryllium disease because ambient air levels of beryllium are normally very low (0.00003-0.0002 ug/m^3 ).

Swallowing beryllium has not been reported to cause effects in humans because very little beryllium is absorbed from the stomach and intestines. Ulcers have been seen in dogs ingesting beryllium in the diet. Beryllium contact with skin that has been scraped or cut may cause rashes or ulcers.

How likely is beryllium to cause cancer?

Long term exposure to beryllium can increase the risk of developing lung cancer in people.

The Department of Health and Human Services (DHHS) and the International Agency for Research on Cancer (IARC) have determined that beryllium is a human carcinogen. The EPA has determined that beryllium is a probable human carcinogen. EPA has estimated that lifetime exposure to 0.04 ug/m^3 beryllium can result in a one in a thousand chance of developing cancer.

How can beryllium affect children?

It is likely that the health effects seen in children exposed to beryllium will be similar to the effects seen in adults. We do not know whether children differ from adults in their susceptibility to beryllium.

We do not know if exposure to beryllium will result in birth defects or other developmental effects in people. The studies on developmental effects in animals are not conclusive.

How can families reduce the risk of exposure to

beryllium?

โ€˜ Individuals working at facilities that use beryllium should make sure that contaminated clothing and objects are not brought home.

โ€˜ Children should avoid playing in soils near uncontrolled hazardous waste sites where beryllium may have been discarded.

Is there a medical test to show whether Iโ€™ve been

exposed to beryllium?

Beryllium can be measured in samples from your blood, urine, skin, or lungs. These tests are rarely done because they are not reliable measures of your exposure over time. Also, these tests do not show if you have become sensitized to beryllium.

Another test, the beryllium lymphocyte proliferation test (BeLPT), can help your doctor decide if you are sensitized to beryllium. This test is only done in a few specialized laboratories, but doctors familiar with the test can collect blood samples and send them for testing by overnight carrier. The BeLPT is most often done for people who work with beryllium. It is also useful for separating chronic beryllium disease from diagnoses that resemble it (for example, sarcoidosis). Depending on your exposure history, clinical findings, and test results, your doctor may also recommend additional specialized testing.

Has the federal government made

recommendations to protect human health?

The EPA restricts the amount of beryllium that industries may release into the air to 0.01 ug/m 3 , averaged over a 30 day period.

The Occupational Safety and Health Administration (OSHA) sets a limit of 2 ug/m 3 for an 8-hour work shift measured as a personal sample.

References

Agency for Toxic Substances and Disease Registry (ATSDR). 2002. Toxicological Profile for Beryllium Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

CAS #7440-41-

BERYLLIUM