BIO 351: Module 6 Test Questions and Answers, Exams of Biology

A series of quiz questions and answers related to bio 351 module 6. The quizzes cover topics such as the development of germ cells, the formation of gonadal structures, sex determination in different species, and genetic factors influencing sexual development. The questions are designed to test understanding of key concepts and mechanisms in developmental biology and genetics, providing a valuable resource for students studying these topics. The material is presented in a question-and-answer format, making it easy to review and reinforce learning. The quizzes cover a range of topics, including the role of retinoic acid in meiosis, the function of bmp4 and bmp8b in primordial germ cell development, and the genetic basis of sex determination in drosophila and mammals. The document also includes questions on congenital adrenal hyperplasia and other genetic disorders affecting sexual development.

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BIO 351 MODULE 6 TEST QUESTIONS AND
ANSWERS
Quiz 6.1 - ANSWER 1. In the developing embryo ______________ induces
female germ cells to enter _______________. Fill in the blanks with the best
answer.
- retinoic acid, meiosis
2. BMP4 and BMP8b are secreted from extraembryonic ectoderm at E7.0. In
response to these factors, competent cells at the posterior of the embryo will
_____, and _________________. Complete the statement.
- Express Fragilis and become primordial germ cells
3. Primordial germ cells follow a migratory path that is directed by which of the
following? Pick the best answer.
- Steel factor and c-Kit
4. Nanos2 transgenic mice had the following phenotype: (pick the best answer)
- Female and male Nanos2 transgenic mice did not enter meiosis embryonically.
Quiz 6.2 - ANSWER 1. The Wolffian duct contributes to which of the
following male gonadal structures?
- Vas deferens
2. A researcher is studying a transcription factor that is essential for the
formation of the mesonephric duct. Based on your knowledge of the developing
urogenital tract, which of the following defects would you predict that you will
find in mice when a knockout mutation has been made in this gene?
- Male mice will have defects of their efferent ducts, epididymis and vas
deferens
3. During the development of the gonads, _____________ and
______________ have the same embryonic origin. Fill in the blanks.
- Sertoli cells and granulosa cells
4. Which of the following is a TRUE statement?
- The initial gonad is bipotential, neither male nor female.
Quiz 6.3 - ANSWER 1. If you had 12 freshly laid Trachemys scripta eggs, and
you wanted to have equal numbers of male and female hatchlings, at which
temperature would you choose to incubate these eggs?
- 28.5°C
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BIO 351 MODULE 6 TEST QUESTIONS AND

ANSWERS

Quiz 6.1 - ANSWER 1. In the developing embryo ______________ induces female germ cells to enter _______________. Fill in the blanks with the best answer.

  • retinoic acid, meiosis
  1. BMP4 and BMP8b are secreted from extraembryonic ectoderm at E7.0. In response to these factors, competent cells at the posterior of the embryo will _____, and _________________. Complete the statement.
  • Express Fragilis and become primordial germ cells
  1. Primordial germ cells follow a migratory path that is directed by which of the following? Pick the best answer.
  • Steel factor and c-Kit
  1. Nanos2 transgenic mice had the following phenotype: (pick the best answer)
  • Female and male Nanos2 transgenic mice did not enter meiosis embryonically. Quiz 6.2 - ANSWER 1. The Wolffian duct contributes to which of the following male gonadal structures?
  • Vas deferens
  1. A researcher is studying a transcription factor that is essential for the formation of the mesonephric duct. Based on your knowledge of the developing urogenital tract, which of the following defects would you predict that you will find in mice when a knockout mutation has been made in this gene?
  • Male mice will have defects of their efferent ducts, epididymis and vas deferens
  1. During the development of the gonads, _____________ and ______________ have the same embryonic origin. Fill in the blanks.
  • Sertoli cells and granulosa cells
  1. Which of the following is a TRUE statement?
  • The initial gonad is bipotential, neither male nor female. Quiz 6.3 - ANSWER 1. If you had 12 freshly laid Trachemys scripta eggs, and you wanted to have equal numbers of male and female hatchlings, at which temperature would you choose to incubate these eggs?
  • 28.5°C
  1. You incubate Alligator missippiensis eggs at 33 C during the TSP. What do you predict is the level of aromatase activity?
  • 10% (lowest level of activity)
  1. If there is a mutation that deletes the male specific exon of sexlethal, what sex would the Drosophila offspring be?
  • All female
  1. During sex determination in Drosophila, _______ and ____________ are _______________ proteins that regulate a cascade of male or female specific gene expression.
  • Sexlethal, Transformer1, splicing factors Quiz 6.4 - ANSWER 1. A conditional Cre knockout of Sox9 was made using a Sf-1cre. This caused Sox9 to be knocked out in the bipotential gonad. What do you expect the phenotype of XY mice to be?
  • Female
  1. Beta-catenin is necessary for ovary development. Which of the following factors are necessary for its activation?
  • Wnt4 and Rspo
  1. What phenotype would you expect to find if you made an SF1 homozygous null mouse mutant?
  • XY and XX embryos would not form a bipotential gonad.
  1. Which of the following constitutes proof of the importance of Sry in male sex determination?
  • Sry transgenic XX mice have complete sex reversal. Quiz 6.5 - ANSWER 1. Human infants with 21-hydroxylase deficiency (congenital adrenal hyperplasia) produce excess _________ , and this results in defects of the ___________. - androgens, external genitalia 2. A delay during embryogenesis in the expression of _________ will result in the development of ________________. Fill in the blanks. - Sry, ovotestes 3. You have a 16 year old female patient that has a lack of menstruation, and is demonstrating male secondary sex characteristics, such as deepening voice, and facial hair. You suspect which of the following may be the problem? - 5 alpha ketosteroid reductase deficiency 4. Which of the following will result in XX males? - Duplication of the Sox9 gene