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Unit 2 Quiz
1. Which level of protein structure is disrupted through the hydrolysis of peptide bonds?
a. Primary
b. Tertiary
c. Secondary
d. Quaternary
Answer: A. The primary structure of a protein is the sequence of amino acids held together by peptide bonds.
Peptide bonds are formed by dehydration reactions and disrupted by hydrolysis.
2. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid
glutamate in position 6 with the amino acid valine, leads to the development of sickle cell anemia. The
structures of glutamate and valine are shown below.
Amino acid structures of glutamate and valine
If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the valine in position 6
was replaced with a different amino acid, which replacement for valine would be expected to have the best clinical
outcome, in theory, for the patient? (Assume the valine can potentially be replaced with any amino acid other than
glutamate.)
A.
b. c. d.
