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A comprehensive overview of the human cardiovascular system, covering key anatomical structures like the heart chambers, valves, and major blood vessels. it delves into physiological processes such as blood flow through the heart and coronary circulation, and explores pathological conditions like angina pectoris and myocardial infarction. The detailed descriptions and question-answer format make it a valuable resource for students studying human anatomy and physiology.
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Pulmonary circuit - Correct Ans-- Right side of heart; carries blood to the lungs for gas exchange and returns it to the heart
Pericarditis - Correct Ans-inflammation of the pericardium Levels of the pericardium (superficial to deep) - Correct Ans-- Pericardial sac
What happens when the ventricles relax? - Correct Ans--pressure drops inside ventricles > semilunar valves close as blood attempts to back up into the ventricles from the vessels > AV valves open > blood flows from atria to ventricles What happens when the ventricles contract? - Correct Ans--AV valves close as blood attempts to back up into the atria > pressure rises inside of the ventricles > semilunar valves open and blood flows into great vessels Blood flow through the heart - Correct Ans- 1 - Superior & Inferior Vena Cava 2 - Rt Atrium, 3-Right AV (Tricuspid) Valve 4 - Rt Ventricle 5 - Pulmonary Valve 6 - Pulmonary Artery 7 - Lungs-pick up oxygen 8 - Pulmonary Veins 9 - Lt Atrium 10 - Left AV (Mitral) Valve (Bicuspid) 11 - Lt Ventricle 12 - Aortic Valve 13 - Aorta 14 - Body Coronary circulation - Correct Ans--5% of blood pumped by heart is pumped to the heart itself through the coronary circulation to sustain its strenuous workload
Parasympathetic nerves - Correct Ans-slow heart rate Pathway begins with nuclei of the vagus nerves in the medulla oblongata Extend to cardiac plexus and continue to the heart by way of the cardiac nerves Fibers of right vagus nerve lead to the SA node Fibers of left vagus nerve lead to the AV node Little or no vagal stimulation of the myocardium systole vs diastole - Correct Ans-Systole = contraction Diastole = relaxation
blood to surge against AV valves. ventricular systole begins at apex of heart, which is first to be stimulated, and moves upward- pushing blood up toward the SL valves. bcus of spiral arrangement of ventricular cardiocytes, ventricles twist slightly as they contract like someone is wringing a towel. Electrical Behavior of the Myocardium - Correct Ans-Depolarization phase (very brief) Stimulus opens voltage-regulated Na^+ gates (Na^+ rushes in), membrane depolarizes rapidly Action potential peaks at +30 mV Na^+ gates close quickly Plateau phase lasts 200 to 250 ms, sustains contraction for expulsion of blood from heart Voltage-gated slow Ca^(2+) channels open admitting Ca^(2+) which triggers opening of Ca^(2+) channels on sarcoplasmic reticulum (SR) Ca^(2+) (mostly from the SR) binds to troponin triggering contraction Repolarization phase: Ca^(2+) channels close, K^+ channels open, rapid diffusion of K^+ out of cell returns it to resting potential Has a long absolute refractory period of 250 ms (compared to 1 to 2 ms in skeletal muscle) Prevents wave summation and tetanus which would stop the pumping action of the heart What is the resting membrane potential of the myocardium - Correct Ans--90mV, depolarize only when stimulated Electrical Behavior of the Myocardium - Correct Ans-1. Na+ gates open
Ventricular filling - Correct Ans-Ventricles expand and their pressure drops below that of the atria AV valves open and blood flows into the ventricles Filling occurs in three phases: Rapid ventricular filling: first one-third Diastasis: second by one-third; slower filling P wave occurs at the end of diastasis Atrial systole: final one-third; atria contract End-diastolic volume (EDV) achieved in each ventricle (about 130 mL of blood) Isovolumetric contraction - Correct Ans-Atria repolarize, relax and remain in diastole for rest of cardiac cycle Ventricles depolarize, causing QRS complex, and begin to contract AV valves close as ventricular blood surges back against the cusps Heart sound S_1 occurs at the beginning of this phase "Isovolumetric" because although ventricles contract, they do not eject blood Pressures in aorta and pulmonary trunk are still greater than those in the ventricles Cardiomyocytes exert force, but with all four valves closed, the blood cannot go anywhere Ventricular ejection - Correct Ans-Begins when ventricular pressure exceeds arterial pressure and semilunar valves open Pressure peaks in left ventricle at about 120 mm Hg and 25 mm Hg in the right First: rapid ejection—blood spurts out of ventricles quickly Then: reduced ejection—slower flow with lower pressure Ejection lasts about 200 to 250 ms - corresponds to plateau phase of cardiac action potential T wave of ECG occurs late in this phase Stroke volume (SV) is about 70 mL Ejection fraction is about 54% of EDV (130 mL) 60 mL remaining blood is end-systolic volume (ESV) = EDV - SV Isovolumitric relaxation - Correct Ans-T wave ends and ventricles begin to expand Blood from aorta and pulmonary trunk briefly flows backward filling cusps and closing semilunar valves Heart sound S2 occurs "Isovolumetric" because semilunar valves are closed and AV valves have not yet opened Ventricles are therefore taking in no blood When AV valves open, ventricular filling begins again Cardiac cycle in a resting person - Correct Ans-Atrial systole lasts about 0.1 second
Also respond to hypoxemia (oxygen deficiency in blood) usually by slowing down the heart Stroke volume - Correct Ans-Preload—the amount of tension in ventricular myocardium immediately before it begins to contract Increased preload causes increased force of contraction Exercise increases venous return and stretches myocardium Cardiomyocytes generate more tension during contraction Increased cardiac output matches increased venous return Contractility refers to how hard the myocardium contracts for a given preload Affected by several chemicals, including electrolyte imbalances (K+ and Ca++) Afterload—sum of all forces opposing ejection of blood from ventricle Largest part of afterload is blood pressure in aorta and pulmonary trunk Opposes the opening of semilunar valves Limits stroke volume Hypertension increases afterload and opposes ventricular ejection Examples of stroke volume - Correct Ans-Increased preload or contractility increases stroke volume Increased afterload decreases stroke volume Exercise and Cardiac output - Correct Ans-Exercise makes the heart work harder and increases cardiac output Proprioceptors signal cardiac center At beginning of exercise, signals from joints and muscles reach the cardiac center of brain Sympathetic output from cardiac center increases cardiac output Increased muscular activity increases venous return Increases preload and ultimately cardiac output Increases in heart rate and stroke volume cause an increase in cardiac output Exercise produces ventricular hypertrophy Increased stroke volume allows heart to beat more slowly at rest Athletes with increased cardiac reserve can tolerate more exertion than a sedentary person Indicate which is the proper sequence of blood flow through the circulatory system: i. Right atrium ii. Left atrium iii. Right ventricle iv. Left ventricle v. Pulmonary artery vi. Pulmonary vein vii. Lungs viii. Systemic tissues ix. Aorta x. Venae cavae
a. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 b. 10, 2, 4, 5, 7, 6, 1, 3, 9, 8 c. 10, 1, 3, 5, 7, 6, 2, 4, 9, 8 d. 10, 1, 2, 3, 4, 5, 7, 6, 9, 8 e. None of the above sequences are correct - Correct Ans-c. 10, 1, 3, 5, 7, 6, 2, 4, 9, 8 The systemic circulation: a. Receives more blood than the pulmonary circulation b. Receives blood from the left ventricle c. Is a high pressure system compared to the pulmonary circulation d. Receives blood from the left ventricle and is a high pressure system compared to the pulmonary circulation e. All of these answers - Correct Ans-d. Receives blood from the left ventricle and is a high pressure system compared to the pulmonary circulation The direction of the impulse through the conduction system of the heart for each cardiac cycle is normally: a. AV node, SA node, AV bundle, Purkinje fibers b. AV node, AV bundle, SA node, Purkinje fibers c. AV bundle, AV node, Purkinje fibers, SA node d. SA node, AV node, AV bundle, Purkinje fibers e. SA node, AV bundle, AV node, Purkinje fibers - Correct Ans-d. SA node, AV node, AV bundle, Purkinje fibers Autorhythmic cells: a. Make up 1% of the heart b. Are able to develop action potentials without CNS input c. "Drift" in and out of threshold at specific rates d. Allow for coordinated muscle contraction in the heart e. All of the above are true of autorhythmic cells - Correct Ans-e. All of the above are true of autorhythmic cells The autorhythm properties of conducting cells in the heart is due to: a. The decrease outward movement of K+ from these cells b. The constant inward movement of Na+ into the these cells c. An increased movement of Ca++ into the cells d. The use of a localized neurotransmitter found only in the conducting cells of the heart e. All of the above EXCEPT D are correct statements concerning autorhythmicity - Correct Ans-b. The constant inward movement of Na+ into the these cells
The period lasting from closure of the AV valve to opening of the aortic valve is known as: a. Isovolumetric ventricular contraction b. Isovolumetric ventricular relaxation c. The rapid ejection phase d. The rapid filling phase e. None of these answers - Correct Ans-a. Isovolumetric ventricular contraction The volume of blood remaining in the ventricles after they have contracted and the semilunar valves have closed is known as the: a. Stroke volume b. Isovolumetric ventricular contraction c. End systolic volume d. Ejection fraction e. Cardiac output - Correct Ans-c. End systolic volume The cardiovascular center for systemic control is located in the: a. Carotid sinus b. SA node c. Medulla oblongata d. Primary motor cortex e. Arterioles - Correct Ans-c. Medulla oblongata Which of the following will not increase stroke volume? a. Increased end-diastolic volume b. Increased contractility of the heart c. Increased end-systolic volume d. Increased stretch of the cardiac muscle fibers during ventricular filling e. Iincreased venous return - Correct Ans-c. Increased end-systolic volume What force continues to drive blood through the vasculature during ventricular diastole? a. Ventricular contraction forces blood into the vasculature during ventricular diastole b. The elastic recoil of the stretched arterial walls provides the force to continue blood flow in the remaining vascular system during ventricular diastole c. Sympathetic stimulation produces arterial vasoconstriction, which drives the blood forward into the arterioles during ventricular diastole d. Skeletal muscle contraction squeezes the blood forward from the arteries during ventricular diastole e. Respiratory movements produce pressure changes in the chest, which establishes a pressure gradient that drives blood forward from the arteries into the microcirculation -
Correct Ans-The elastic recoil of the stretched arterial walls provides the force to continue blood flow in the remaining vascular system during ventricular diastole Elastic recoil of large arteries occurs during: a. Ventricular diastole b. Ventricular systole c. During the entire cardiac cycle d. Only when cardiac output is very low e. Both A and D are true statements - Correct Ans-a. Ventricular diastole The prime defect in heart failure is: a. A decrease in cardiocyte contractility, making a "weak" heart b. An increase in stroke volume c. A decrease in heart rate d. An increase in EDV (EFFECT) e. A decrease in an individual's cardiac reserve - Correct Ans-a. A decrease in cardiocyte contractility, making a "weak" heart Organs that recondition the blood: a. Receive disproportionately large percentages of the cardiac output b. Can withstand temporary reductions in blood flow much better than can organs that do not recondition the blood c. Must receive a constant blood supply in order to maintain homeostasis d. Both (a) and (b) above e. Both (a) and (c) above - Correct Ans-e. Both (a) and (c) above A. stroke volume if EDV is 130ml and ESV is 30ml B. stroke volume if EDV is 140ml and ESV is 60 ml a. A is greater than B b. B is greater than A c. Both A and B are equal - Correct Ans-a. A is greater than B A. Cardiac output if stroke volume is 70ml and heartrate is 70 bpm B. Cardiac output if stroke volume is 60ml and heartrate is 80 bpm a. A is greater than B b. B is greater than A c. Both A and B are equal - Correct Ans-a. A is greater than B A. volume of blood in ventricles at isometric ventricular relaxation B. volume of blood in ventricles at isometric ventricular contraction
e. Slight vasoconstriction of veins increases stroke volume - Correct Ans-b. Decreased end diastolic volume increases cardiac output If a disease caused an increase in blood pressure, what event must occur in total peripheral resistance to maintain the same degree of blood flow to tissues? a. Resistance must also increase to meet flow demands b. Resistance must decrease to maintain consistent blood flow c. There is no relationship between blood pressure and peripheral resistance, so no homeostatic response is required d. Total peripheral resistance cannot be altered or changed homeostatically e. An increase in blood pressure must effect blood flow to tissues, altering resistance would not have a homeostatic effect - Correct Ans-b. Resistance must decrease to maintain consistent blood flow Blood flow is affected by: a. Pressure differences b. The viscosity of the blood c. The amount of friction in the blood vessels d. The length and diameter of the blood vessels e. All of these answers - Correct Ans-e. All of these answers Which is NOT true of blood pressure: a. Its maximal during ventricular systole b. It decreases the farther away from the heart c. It increases with increasing resistance d. It decreases with increasing vessel diameter e. It can be increased by direct parasympathetic activity - Correct Ans-e. It can be increased by direct parasympathetic activity If the arterial blood pressure is recorded at 132/84, what is the mean arterial pressure? a. 100 mm Hg b. 93 mm Hg c. 108 mm Hg d. 48 mm Hg e. None of these answers - Correct Ans-a. 100 mm Hg Which of the following factors is most important in matching the blood flow through a specific tissue with the metabolic needs of that tissue? a. Sympathetically induced vasoconstriction of the arteries supplying a tissue forces more blood to flow into the tissue
b. Parasympathetically induced vasodilation of the capillaries within a tissue allows more blood to flow into the tissue c. Local changes within a tissue resulting from increased metabolic activity can produce local arteriolar vasodilation to allow more blood to flow into the tissue d. Widespread venous vasoconstriction allows blood to dam up at the tissue level e. The amount of blood flowing through each tissue remains constant through reflex controls to ensure that metabolic needs are continuously met - Correct Ans-c. Local changes within a tissue resulting from increased metabolic activity can produce local arteriolar vasodilation to allow more blood to flow into the tissue Functions of respiration - Correct Ans--Gas exchange: O2 and CO2 exchanged between blood and air