Cell Adaptations - Pathology - Lecture Slides, Slides of Pathology

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CELL ADAPTATIONS

CELL INJURY

CELL DEATH

OBJECTIVES

Understand the 3 main anatomic concepts of disease---Degenerative, Inflammatory, Neoplastic

Understand the concepts of cellular growth adaptations---Hyperplasia, Hypertrophy, Atrophy, Metaplasia

Understand the factors of cell injury and death---O2, Physical, Chemical, Infection, Immunologic, Genetic, Nutritional

OBJECTIVES

Identify common INTRA-cellular

accumulations---Fat, Hyaline, CA++, Proteins, Glycogen, Pigments

Understand aging and differentiate the

concepts of preprogrammed death versus wear and tear.

PATHOLOGY

Pathos (suffering)

Logos

PATHOLOGY

• ETIOLOGY (“Cause”)
• PATHOGENESIS (“Insidious

development”)

• MORPHOLOGY (ABNORMAL

ANATOMY)

• CLINICAL EXPRESSION

ETIOLOGY

• Cause

vs.

• Risk Factors

MORPHOLOGY

• Abnormal Anatomy
  • Gross
  • Microscopic
  • Radiologic
  • Molecular

CLINICAL EXPRESSION

• Ironically, even though “clinical expression” is not often present in subclinical diseases, it is the “pathos” of pathology.

CLINICAL/FUNCTIONAL

Rudolph Virchow

1821-

The Father of Modern Pathology

FUNCTIONAL DEFINITION OF

DISEASE

HOMEOSTASIS

The – plasia brothers

• HYPER-
• HYPO- (A-)
• NORMO-
• META-
• DYS-
• ANA-
• “Frank” ANA-

HYPO-TROPHY?

DE-CREASE IN SIZE OF CELLS?

RARELY

USED

TERM Docsity.com

ATROPHY

• DECREASED WORKLOAD
• DENERVATION
• DECREASED BLOOD FLOW
• DECREASED NUTRITION
• AGING (involution)
• PRESSURE

METAPLASIA

• A SUBSTITUTION of one NORMAL CELL or TISSUE type, for ANOTHER - COLUMNAR  SQUAMOUS (Cervix) - SQUAMOUS  COLUMNAR (Glandular) (Stomach) - FIBROUS  BONE - WHY?