The Discovery and Postulates of the Cell Theory, Lecture notes of Biology

The Cell Theory is a scientific concept that describes all living organisms as being composed of one or more cells, which are the basic unit of life. This theory was developed through the observations of scientists such as Robert Hooke, Anton van Leeuwenhoek, Matthias Schleiden, Theodor Schwann, and Rudolf Virchow. In this document, we will discuss the history of the cell theory and its postulates.

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General Biology 1 SHS
Week 1
Lesson 1. The Cell Theory
Cells are the basic building blocks of all living things. The human body is
composed of trillions of cells. They provide structure for the body, take in nutrients from
food, convert those nutrients into energy, and carry out specialized functions. Cells also
contain the body’s hereditary material and can make copies of themselves. Cells have
many parts, each with a different function. Some of these parts, called organelles, are
specialized structures that perform certain tasks within the cell. In this lesson, you are to
explain the postulates of the cell theory. The three postulates of the cell theory offer the
basis on how an organism is considered as a living thing.
Prior to the invention of the very first microscope, everything that could not be
seen by the naked eye was unexplainable. In 1665, English physicist Robert Hooke
used of the first light microscopes to look at thin slices of plant tissues. One of these, a
slice of cork, especially caught his eye. Under the microscope, cork seemed to be made
of thousands of tiny chambers. Hooke called this chambers ―cells‖ because they
reminded him of a monastery‘s tiny rooms, which were also known as cells. Until 1676,
Anton van Leeuwenhoek published his observations on tiny living organisms which he
named animalcules. It was believed that Leeuwenhoek was the first to observe under
his microscope the structure of a red blood cell of different animals as well as a sperm
cell. One of the leading botanists in his time, Robert Brown in 1831 was able to
compare diverse kinds of plant specimens under the microscope. He markedly indicated
that there is a common thing about them-they are all composed of cells, and inside the
cell is a dark dense spot which he termed as the nucleus. A few years later, German
botanist Matthias Schleiden (1838) concluded that all plant parts are made of cells.
Theodor Schwann (1839), also a botanist and a close friend of Schleiden, stated that all
animal tissues are composed of cells, too. In 1858, Rudolf Virchow concluded that all
cells come from pre-existing cells.
The discoveries made by Hooke, Leeuwenhoek, Schleiden, Schwann, Virchow,
and others led to the formulation of the cell theory. The cell theory describes the
properties of all cells. This theory can be summed up into three basic components: (1)
all living things are composed of one or more cells; (2) the cell is the basic unit of life;
and (3) all cells arise from pre-existing cells. Now, that you have an understanding of
the history of the cell theory, answer the activity that follows. What’s More A. The
Discovery of Cell Matthias Schleiden Robert Hooke Theodor Schwann Anton van
Leeuwenhoek Rudolf Virchow
Activity 1. Research on the ―Cell Theory which tells about the discovery of cell. Take
note of the scientists and their respective works.
Matthias Schleiden, Robert Hooke, Theodor Schwann , Anton van Leeuwenhoek,
Rudolf Virchow
Choose from above which scientist gave the following statements.
__________1. All cells come from pre-existing cells (1858).
__________2. All animals are made up of cells (1839).
__________3. All plants are made up of cells (1838).
__________4. Tiny living organisms are observed (1676).
__________5. Thousands of tiny empty chambers in cork are called cells (1665).
Activity 2: Answer the following questions on a separate sheet of paper.
1.What is the cell theory and what does it state?
_________________________________________________________________
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General Biology 1 SHS

Week 1

Lesson 1. The Cell Theory Cells are the basic building blocks of all living things. The human body is composed of trillions of cells. They provide structure for the body, take in nutrients from food, convert those nutrients into energy, and carry out specialized functions. Cells also contain the body’s hereditary material and can make copies of themselves. Cells have many parts, each with a different function. Some of these parts, called organelles, are specialized structures that perform certain tasks within the cell. In this lesson, you are to explain the postulates of the cell theory. The three postulates of the cell theory offer the basis on how an organism is considered as a living thing. Prior to the invention of the very first microscope, everything that could not be seen by the naked eye was unexplainable. In 1665, English physicist Robert Hooke used of the first light microscopes to look at thin slices of plant tissues. One of these, a slice of cork, especially caught his eye. Under the microscope, cork seemed to be made of thousands of tiny chambers. Hooke called this chambers ―cells‖ because they reminded him of a monastery‘s tiny rooms, which were also known as cells. Until 1676, Anton van Leeuwenhoek published his observations on tiny living organisms which he named animalcules. It was believed that Leeuwenhoek was the first to observe under his microscope the structure of a red blood cell of different animals as well as a sperm cell. One of the leading botanists in his time, Robert Brown in 1831 was able to compare diverse kinds of plant specimens under the microscope. He markedly indicated that there is a common thing about them-they are all composed of cells, and inside the cell is a dark dense spot which he termed as the nucleus. A few years later, German botanist Matthias Schleiden (1838) concluded that all plant parts are made of cells. Theodor Schwann (1839), also a botanist and a close friend of Schleiden, stated that all animal tissues are composed of cells, too. In 1858, Rudolf Virchow concluded that all cells come from pre-existing cells. The discoveries made by Hooke, Leeuwenhoek, Schleiden, Schwann, Virchow, and others led to the formulation of the cell theory. The cell theory describes the properties of all cells. This theory can be summed up into three basic components: (1) all living things are composed of one or more cells; (2) the cell is the basic unit of life; and (3) all cells arise from pre-existing cells. Now, that you have an understanding of the history of the cell theory, answer the activity that follows. What’s More A. The Discovery of Cell Matthias Schleiden Robert Hooke Theodor Schwann Anton van Leeuwenhoek Rudolf Virchow Activity 1. Research on the ―Cell Theory which tells about the discovery of cell. Take note of the scientists and their respective works. Matthias Schleiden, Robert Hooke, Theodor Schwann , Anton van Leeuwenhoek, Rudolf Virchow Choose from above which scientist gave the following statements. __________1. All cells come from pre-existing cells (1858). __________2. All animals are made up of cells (1839). __________3. All plants are made up of cells (1838). __________4. Tiny living organisms are observed (1676). __________5. Thousands of tiny empty chambers in cork are called cells (1665). Activity 2 : Answer the following questions on a separate sheet of paper. 1.What is the cell theory and what does it state?


  1. What do we call the basic generalizations that are accepted by modern science about cell? _________________________________________________________________
  2. Among the scientists, who advanced the cell theory with his conclusion that cells could only come from other cells?

  1. What discovery is Van Leeuwenhoek noted for?

  1. What caused scientists to discover the existence of cells?

Activity 3: Research on the theory of spontaneous generation or theory of abiogenesis by Stanley Miller and Francesco Redi and Louis Pasteur‘s experiment. Compare the two theories on the origin of life. Watch a video through YouTube link below entitled “Theories on the Origin of Life”, https://www.youtube.com/watch?v=2QLW7I_XBqo https://www.youtube.com/watch?v=NNijmxsKGbc Lesson 2: Cell Structure and Functions All living organisms are made up of one or many cells. The cells are the building block of life just as atoms are the basic building blocks of all matter. Each cell contains materials that carry out basic life processes. Cell structures can only be observed under high magnification electron microscope and are separated internally into numerous membranous compartments called organelles (little organs). These organelles perform a variety of functions like production of proteins, storage of important materials, harvesting energy, repairing cell parts, digestion of substances, and maintaining the shape and structure of the cell. Cell Structure and Functions Cells’ Structures Functions 1. Cell Membrane - Separates cell from external environment; controls passage of organic molecules, ions, water, oxygen and wastes into and out of the cell

  1. Cytoplasm -Provides structure to cell; site of many metabolic reactions; medium in which organelles are found
  2. Nucleolus - Location of DNA
  3. Nucleus - Cell organelle that houses DNA and directs synthesis of ribosomes and proteins
    1. Ribosomes -Protein synthesis
  4. Mitochondria - ATP production or cellular respiration
  5. Peroxisomes -Oxidizes and breaks down fatty acids and amino acids and detoxifies poisons
  6. Vesicles and Vacuoles -Storage and transport; digestive function in plant cells
  7. Centrosome -Unspecified role in cell division in animal cells; organizing center of microtubules in animal cells
  8. Lysosomes -Digestion of macromolecules; recycling or worn out organelles
  9. Cell wall -Protection, structural support and maintenance of cell shape
  10. Chloroplast -Photosynthesis
  11. Endoplasmic reticulum - Modifies proteins and synthesizes lipids
  12. Golgi apparatus - Modifies, sorts, tags, packages and distributes lipids and proteins
  13. Cytoskeleton - Maintains cell‘s shape, secure organelles on specific positions, allows cytoplasm and vesicles to move within the cell, and enables unicellular organisms to move independently
    1. Flagella -Cellular locomotion
    2. Cilia -Cellular locomotion, movement of particles along extracellular surface of plasma membrane, and filtration

tissue is commonly seen outside the body as coverings or as linings of organs and cavities. Epithelial tissues are characterized by closely-joined cells with tight junctions (i.e., a type of cell modification). Being tightly packed, tight junctions serve as barriers for pathogens, mechanical injuries, and fluid loss. Cells that make up epithelial tissues can have distinct arrangements:

  • cuboidal—for secretion
  • simple columnar—brick-shaped cells; for secretion and active absorption
  • simple squamous—plate-like cells; for exchange of material through diffusion
  • stratified squamous—multilayered and regenerates quickly; for protection
  • pseudo-stratified columnar—single layer of cells; may just look stacked because of varying height; for lining of respiratory tract; usually lined with cilia (i.e., a type of cell modification that sweeps the mucus). Connective Tissue—These tissues are composed of the following: BLOOD —made up of plasma (i.e., liquid extracellular matrix); contains water, salts, and dissolved proteins; erythrocytes that carry oxygen (RBC), leukocytes for defense (WBC), and platelets for blood clotting. CONNECTIVE TISSUE PROPER (CTP)—made up of loose connective tissue that is found in the skin and fibrous connective tissue that is made up of collagenous fibers found in tendons and ligaments. Adipose tissues are also examples of loose connective tissues that store fats which functions to insulate the body and store energy. CARTILAGE —characterized by collagenous fibers embedded in chondroitin sulfate. Chondrocytes are the cells that secrete collagen and chondroitin sulfate. Cartilage functions as cushion between bones. BONE —mineralized connective tissue made by bone-forming cells called osteoblasts which deposit collagen. The matrix of collagen is combined with calcium, magnesium, and phosphate ions to make the bone hard. Blood vessels and nerves are found at a central canal surrounded by concentric circles of osteons. Muscle Tissue —These tissues are composed of long cells called muscle fibers that allow the body to move voluntary or involuntary. Movement of muscles is a response to signals coming from nerve cells. In vertebrates, these muscles can be categorized into the following:
  • skeletal—striated; voluntary movements
  • cardiac—striated with intercalated disk for synchronized heart contraction; involuntary
  • smooth—not striated; involuntary Nervous Tissue —These tissues are composed of nerve cells called neurons and glial cells that function as support cells. These neurons sense stimuli and transmit electrical signals throughout the animal body. Neurons connect to other neurons to send signals. The dendrite is the part of the neuron that receives impulses from other neurons while the axon is the part where the impulse is transmitted to other neurons. Activity 9: Direction: Identify which type of connective tissue (A-C) , epithelial tissue (D- F) , and muscle tissue (G-I) is being described. A. _______________transport oxygen, carbon dioxide, nutrients and waste through the body by travelling through the vessels called arteries and veins. B. _______________is a type of dense connective tissue that connects muscles to bones and connects bone to bone. C. _______________is a type of connective tissue with one of the hardest extracellular matrixes that forms a protective structure used for muscle attachment. D. _______________found in respiratory tract (trachea), usually lined with cilia. E. _______________found in air sacs/alveoli of the lungs, capillaries. F. _______________found in digestive tract for secretion and active absorption G. _______________muscles of the heart; involuntary movements. H. _______________involuntary contractions of digestive tract like esophagus, stomach and intestines. I. ________________striated; voluntary movements like biceps and abdominal muscles. Domingo S. Soriao Jr