all'eIFs
all'eIFs'
except'
eIF4E
eIF2,'eIF3
21
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Cellular - Human Resource - Lecture Slides, Slides of Human Resource Management
In these Lecture Slides of Human Resource Management, the Lecturer has put emphasis on the following key points : Cellular, Viral, Picornaviruses, Flaviviruses, Vascular, Endothelial, Growth, Factor, Protein, Kinase
Typology: Slides
2012/2013
1 / 10
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all eIFs
all eIFs
except
eIF4E
eIF2, eIF
• Viral IRESes
– Picornaviruses
– Flaviviruses (hepaKKs
C virus)
– PesKviruses (bovine
viral diarrhea virus, classical swine fever virus)
– Retroviruses (SIV,
MMLV, HTLV, FLV)
– Insect picorna-‐like
viruses (cricket paralysis virus, PlauKa stali intesKne virus)
• Cellular IRESes
- BiP
- c-‐Myc - Antennapaedia
- Ornithine decarboxylase
- Fibroblast growth factor
- Vascular endothelial growth factor
- protein kinase p58PITSLRE
Methionine-‐independent ini'a'on
- Can assemble 80S ribosomes without any eIFs or Met-‐tRNAi
- RNA mimics tRNAi
RNA genome of cricket paralysis virus Binds 40S ribosome independent of iniKaKon proteins
Maximizing the coding capacity of the viral genome
- Polyprotein^ ( Picornaviridae, Flaviviridae, Togaviridae, Arenaviridae, Bunyaviridae, Retroviridae )
- Internal iniKaKon (IRES)^ ( Picornaviridae, Flaviviridae)
- Leaky scanning^ ( Retroviridae, Paramyxoviridae)
- Re-‐iniKaKon of translaKon^ ( Orthomyxoviridae, Herpesviridae )
- Suppression of terminaKon^ ( Retroviridae, Togaviridae)
- Ribosomal frameshiaing^ ( Retroviridae)
Polyprotein synthesis
Re-‐ini'a'on of transla'on