Inflammation and Immunity: Concepts and Mechanisms, Exams of Nursing

A comprehensive overview of inflammation and immunity, covering key concepts and mechanisms. It includes multiple-choice questions and answers, making it a valuable resource for students of medical-surgical nursing. The role of inflammation and immunity in maintaining health, preventing disease, and repairing tissue damage. It also delves into the different types of immunity, including antibody-mediated and cell-mediated immunity, and the cells involved in these processes. The document further examines the cardinal signs of inflammation and the steps involved in making antigen-specific antibodies.

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2024/2025

Available from 04/11/2025

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Chapter 16: Concepts of Inflammation and
Immunity Ignatavicius: Medical-Surgical Nursing,
10th Edition 2024-2025 Verified Answers
1. The nurse learns that the most important function of inflammation and immunity is
which purpose?
a. Destroying bacteria before damage occurs
b. Preventing any entry of foreign material
c. Providing maximum protection against infection
d. Regulating the process of self-tolerance - correct answer>>ANS: C
Immunity and Inflammation working together are critical to maintaining health,
preventing disease, and repairing tissue damage. When all the different parts and
functions of immunity are working well, the adult is immunocompetent and has
maximum protection against infection. Working together, their function is not limited to
destroying bacteria before damage occurs. They do not prevent the entry of all foreign
materials and immunity alone regulates the process of self-tolerance.
2. A nurse is assessing an older client for the presence of infection. The client's
temperature is 97.6° F (36.4° C). What response by the nurse is best? a.
Assess the client for more specific signs.
b. Conclude that an infection is not present.
c. Document findings and continue to monitor.
d. Request the primary health care provider order blood cultures - correct answer>>ANS:
A
Because older adults have decreased immune function, including reduced neutrophil
function, fever may not be present during an episode of infection. The nurse would
assess the client for specific signs of infection. Documentation needs to occur, but a
more thorough assessment comes first. Blood cultures may or may not be needed
depending on the results of further assessment
3. A clinic nurse is working with an older client. What action is most important for
preventing infections in this client?
a. Assessing vaccination records for booster shot needs b. Encouraging the client to eat a
nutritious diet
c. Instructing the client to wash minor wounds carefully
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Chapter 16: Concepts of Inflammation and

Immunity Ignatavicius: Medical-Surgical Nursing,

10th Edition 2024 - 2025 Verified Answers

  1. The nurse learns that the most important function of inflammation and immunity is which purpose? a. Destroying bacteria before damage occurs b. Preventing any entry of foreign material c. Providing maximum protection against infection d. Regulating the process of self-tolerance - correct answer>>ANS: C Immunity and Inflammation working together are critical to maintaining health, preventing disease, and repairing tissue damage. When all the different parts and functions of immunity are working well, the adult is immunocompetent and has maximum protection against infection. Working together, their function is not limited to destroying bacteria before damage occurs. They do not prevent the entry of all foreign materials and immunity alone regulates the process of self-tolerance.
  2. A nurse is assessing an older client for the presence of infection. The client's temperature is 97.6° F (36.4° C). What response by the nurse is best? a. Assess the client for more specific signs. b. Conclude that an infection is not present. c. Document findings and continue to monitor. d. Request the primary health care provider order blood cultures - correct answer>>ANS: A Because older adults have decreased immune function, including reduced neutrophil function, fever may not be present during an episode of infection. The nurse would assess the client for specific signs of infection. Documentation needs to occur, but a more thorough assessment comes first. Blood cultures may or may not be needed depending on the results of further assessment
  3. A clinic nurse is working with an older client. What action is most important for preventing infections in this client? a. Assessing vaccination records for booster shot needs b. Encouraging the client to eat a nutritious diet c. Instructing the client to wash minor wounds carefully

d. Teaching hand hygiene to prevent the spread of microbes - correct answer>>ANS: A Older adults may have insufficient antibodies that have already been produced against microbes to which they have been exposed. Therefore, older adults need booster shots for many vaccinations they received as younger people. A nutritious diet, proper wound care, and hand hygiene are relevant for all populations.

  1. A client has a leg wound that is in Stage II of the inflammatory response. For what sign or symptom does the nurse assess? a. Noticeable rubor b. Purulent drainage c. Swelling and pain d. Warmth at the site - correct answer>>ANS: B During the second phase of the inflammatory response, neutrophilia occurs, producing pus. Rubor (redness), swelling, pain, and warmth are cardinal signs of the general inflammatory process
  2. A nurse learning about antibody-mediated immunity learns that the cell with the most direct role in this process begins development in which tissue or organ? a. Bone marrow b. Spleen c. Thymus d. Tonsils - correct answer>>ANS: A The B-cell is the primary cell in antibody-mediated immunity and is released from the bone marrow. These cells then travel to other organs and tissues, known as the secondary lymphoid tissues for B-cells.
  3. The nurse understands that which type of immunity is the longest acting? a. Artificial active b. Inflammatory c. Natural active d. Natural passive - correct answer>>ANS: C Natural active immunity is the most effective and longest acting type of immunity. Artificial and natural passive do not last as long. "Inflammatory" is not a type of immunity.
  4. The nurse working with clients who have autoimmune diseases understands that what component of cell-mediated immunity is the problem? a. CD4+ cells

a. "The white cell count does not tell us everything about immunity." b. "White blood cells are less active in older people so they are not as efficient." c. "Older people typically have poor nutrition which makes them prone to infection." d. "As one ages, immunoglobulins cease to be produced in response to illness." - correct answer>>ANS: B An age-related change in immunity is that neutrophils in the older adult are less active and therefore less effective in immunity. The white blood cell count is not the only thing that can inform about immunity, but this response is too vague to be useful. Many older adults do have poor nutrition that does affect immunity, but this is not true for everyone and the stem does not contain information stating that is problematic for this older adult. Immunoglobulins do not cease to be produced with age.

  1. For a person to be immunocompetent, which processes need to be functional and interact appropriately with each other? (Select all that apply.) a. Antibody-mediated immunity b. Cell-mediated immunity c. Inflammation d. Red blood cells e. White blood cells - correct answer>>ANS: A, B, C The three processes that need to be functional and interact with each other for a person to be immunocompetent are antibody-mediated immunity, cell-mediated immunity, and inflammation. Red and white blood cells are not processes.
  2. A nurse is learning about the types of different cells involved in the inflammatory response. Which principles does the nurse learn? (Select all that apply.) a. Basophils are only involved in the general inflammatory process. b. Eosinophils increase during allergic reactions and parasitic invasion. c. Macrophages can participate in many episodes of phagocytosis. d. Monocytes turn into macrophages after they enter body tissues. e. Neutrophils can only take part in one episode of phagocytosis. - correct answer>>ANS: B, C, D, E Eosinophils do increase during allergic and parasitic invasion. Macrophages participate in many episodes of phagocytosis. Monocytes turn into macrophages after they enter body tissues. Neutrophils only take part in one episode of phagocytosis. Basophils are involved in both the general inflammatory response and allergic or hypersensitivity responses
  1. The nurse assesses clients for the cardinal signs of inflammation. Which signs/symptoms does this include? (Select all that apply.) a. Edema b. Pulselessness c. Pallor d. Redness e. Warmth f. Decreased function - correct answer>>ANS: A, D, E, F The five cardinal signs of inflammation include redness, warmth, pain, swelling, and decreased function.
  2. Which are steps in the process of making an antigen-specific antibody? (Select all that apply.) a. Antibody-antigen binding b. Invasion c. Opsonization d. Recognition e. Sensitization f. Production - correct answer>>ANS: A, B, D, E, F The seven steps in the process of making antigen-specific antibodies are: exposure/invasion, antigen recognition, sensitization, antibody production and release, antigen-antibody binding, antibody binding actions, and sustained immunity. Opsonization is the adherence of an antibody to the antigen, marking it for destruction.
  3. The nurse is learning about immunoglobulins.. Which principles does the nurse learn? (Select all that apply.) a. IgA is found in high concentrations in secretions from mucous membranes. b. IgD is present in the highest concentrations in mucous membranes. c. IgE is associated with antibody-mediated hypersensitivity reactions. d. IgG comprises the majority of the circulating antibody population. e. IgM is the first antibody formed by a newly sensitized B-cell. - correct answer>>ANS: A, C, D, E Immunoglobulin A (IgA) is found in high concentrations in secretions from mucous membranes. Immunoglobulin E (IgE) is associated with antibody-mediated hypersensitivity reactions. The majority of the circulating antibody population consists of immunoglobulin G (IgG). The first antibody formed by a newly sensitized B-cell is

c. Plasma cell: secretes immunoglobulins in response to the presence of a specific antigen. d. Cytotoxic T-cells: attacks and destroys ingested poisons and toxins. e. Natural killer cell: nonselectively attacks non-self cells. f. Regulator T-cells: become sensitized for self-recognition in the bone marrow. - correct answer>>ANS: A, C, E Monocytes mature into macrophages, plasma cells secrete immunoglobulin in the presence of specific antigens, and natural killer cells nonselectively attack non-self cells. Basophils release histamines, kinins, and heparin in areas of tissue damage. Cytotoxic Tcells selectively attack and destroy non-self cells, including virally infected cells, grafts, and transplanted organs. Regulator T-cells become sensitized for self- recognition in the thymus.

  1. A nurse is studying the function of immunoglobulins. Which immunoglobulins are correctly matched to their function? (Select all that apply.) a. IgA: most responsible for preventing infection in the respiratory tracts, the GI tract, and the genitourinary tract. b. IgD: provides protection against parasite infestations, especially helminths. c. IgE: associated with antibody-mediated immediate hypersensitivity reactions. d. IgG: activates classic complement pathway and enhances neutrophil and macrophage actions. e. IgM: first antibody formed by a newly sensitized B-lymphocyte plasma cell. - correct answer>>ANS: A, C, D, E All options are true except IgD acts as a B-cell antigen receptor. IgE provides protection against parasite infestations, especially helminths.
  2. The nurse caring for clients assesses their daily laboratory profiles. Which lab results are considered to be in the normal range? (Select all that apply.) a. Segmented neutrophils: 68% b. Bands: 19% c. Monocytes: 12% d. Lymphocytes: 38% e. Eosinophils: 2% f. Basophils: 1% - correct answer>>ANS: A, D, E, F The normal range for segmented neutrophils is 55% to 70%. The normal range for bands is 5%. The normal range for monocytes is 2% to 8%. The normal range for lymphocytes is

20% to 40%. The normal range for eosinophils is 1% to 4%. The normal range for basophils is 0.5% to 1%.

  1. What statements about the complement system are correct? (Select all that apply.) a. Comprised of 20 types of inactive plasma proteins. b. Act as enzymes when activated to enhance innate immunity. c. Phagocytize foreign invaders quickly by destroying their membranes. d. Sticks to the antigen and forms a membrane attack complex. e. Maintain and prolong inflammation from non-self cells. f. Is part of the innate immune system. - correct answer>>ANS: A, B, D, F The complement system is made up of 20 different types of inactive plasma proteins that, when activated, act as enzymes to enhance (or complement) cell actions in innate immunity. They join other proteins to surround antigens and "fix" or stick to the antigen quickly forming a membrane attack complex on the antigen surface. This action makes immune cell attachment to antigens and phagocytosis more efficient. They are part of innate immunity. They do not phagocytize invaders themselves nor do they maintain and prolong inflammation from allergens.