Heritability and Quantitative Trait Loci (QTL) Mapping: Exercises and Examples, Exercises of Biology

A series of exercises and examples related to heritability and quantitative trait loci (qtl) mapping. It explores concepts like phenotypic variation, genetic and environmental influences, and the use of twin studies to estimate heritability. The document also includes examples of qtl mapping, demonstrating how markers are associated with traits and how to calculate the relative probability of a marker being linked to a trait. This resource is valuable for students studying genetics and quantitative genetics, providing practical applications of these concepts.

Typology: Exercises

2020/2021

Uploaded on 01/31/2025

ben-loud
ben-loud 🇺🇸

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Genetically homogeneous
All variation due to environment (VP = VE)
VP = VE = 0.057 cm2
VP = 0.563 cm2
VP = VG + VE
VG = VP - VE
VG = 0.563 - 0.057
= 0.506
H2 = VG / VP
= 0.506 / 0.563
= 0.899
Wilkens (2010) Heredity
What is the heritability of eye size?
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Genetically homogeneous All variation due to environment ( V P = V E) V P = V E = 0.057 cm 2 V P = 0.563 cm 2

V P = V G + V E

V G = V P - V E

V G = 0.563 - 0.

H

2

= V G / VP

Wilkens (2010) Heredity What is the heritability of eye size?

Using Twins to Study Heritability of Traits Monozygotic “identical” twins: V P = V E V E = 15 cm 2 Dizygotic “fraternal” twins: V P = V E + ( 1 / 2 ) V G V G = 2( V P - V E) = 2(25 - 15) = 20 Calculating heritability: H 2 = V G / VP = 20 / 25 = 0. You measure height in 100 monozygotic twins, and calculate that the variance in height is 15 cm 2

. You do the same for dizygotic twins, and get a variance of 25 cm 2 . What is the heritability of height? A) 20% B) 40% C) 60% D) 80% E) 90%

Are the following haplotypes in linkage disequilibrium?

A. Yes

B. No

Haplotype Frequency A 1 B 1 0. A 1 B 2 0. A 2 B 1 0. A 2 B 2 0. Gene A Freq(A 1 ) = 0. Freq(A 2 ) = 0. Gene B Freq(B 1 ) = 0. Freq(B 2 ) = 0. Expectations Exp(A 1 B 1 ) = (0.5)(0.5) = 0. Exp(A 1 B 2 ) = (0.5)(0.5) = 0. Exp(A 2 B 1 ) = (0.5)(0.5) = 0. Exp(A 2 B 2 ) = (0.5)(0.5) = 0.

QTL Mapping

Genotype the backcross progeny

DNA test!

100% L allele?

Why are the F1 individuals

intermediate size?

A. Fruit size is controlled by

a single gene with a

dominant allele

B. Fruit size is controlled by

multiple genes with

additive effects

C. Fruit size is controlled

entirely by environmental

factors

QTL Mapping

relative probability that marker is associate with trait 100x more likely than chance Quantitative Trait Loci (QTL) associated with fruit size Which of the following statements is true? A) The genes TG353, TG469, TG93, and TG140 affect fruit size B) There is a gene near TG469 that affects fruit size C) The genes R455, TG396, and TG14 affect fruit size D) There is a gene near TG396 that affects fruit size