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ARHOLIADAU EXAMINATIONS
SEMESTER 1 EXAMINATIONS 2010
IBERS (BIOLOGICAL SCIENCES)
BS34520 FUNCTIONAL GENOMICS
TIME ALLOWED: TWO HOURS
ANSWER ONE QUESTION FROM EACH SECTION
SECTION A
1. Describe the techniques and organisms that are being used to determine the
minimal set of genes required to sustain bacterial life. Discuss the benefits that
are likely to arise from our understanding of the minimal set of genes required for
life. (20 marks)
SECTION B
2. Explain how the chemical modification of DNA is integrated into the control of
expression of genes. (20 marks)
3. Describe how proteomics methodologies are being used to investigate protein
function. What are the main benefits and limitations of the proteomics approach?
(20 marks)
4. Compare two ‘omics technologies for investigation of gene function and highlight
their advantages and disadvantages. Explain how these techniques are being
developed and indicate the benefits that are likely to emerge. (20 marks)
5. Describe the process by which the High Resolution Melt (HRM) method can be
used to determine the presence of Single Nucleotide Polymorphisms in a DNA
sequence. What are the main benefits of this approach compared with other SNP
detection methods? (20 marks)
