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You are seeing MICROCEPHALI a . e Complication of varicella in-utero | Xx * Disease is corte by euler rashes accompanied by fever and malaise | Id wide(both endemic and epidemic) © att History...... oe was a description of an illness similar to chicken pox more than 2,000 years ago in ancient Babylonian era. In 800’s/900's AD, Muhammad ibn Zakariya Razi, recorded some of the first known information on chicken pox and noted the Selle tll between measles and small pox. , In 1875, Rudolf Steiner, proved that chicken pox infection is contagious. Fluid from a chicken pox blister rubbed on the skin of healthy volunteers and the volunteers got chicken pox. Von Bokay suggested the connection between shingles and chicken pox in 1909. In 1920’s/1930’s studies confirmed the connection when children inoculated with zoster vesicles Ne virus) came down with chicken pox. Aetiological agent (HAHWV3) ¢ dsDNA virus F Copyright 1994 - ‘97 Marko Reschhe 0 100 200 300 400 500 600 650A Glycoprotein Envelope Nucleocapsid Tegument (viral dsDNA) zoster ¢ Virus present in . ecretion and lesions of skinjaail Period of infectivity 1 — 2 days before the appea rance of rash 4 —5 days after the appearance of rash Virus tends to die out before Petule stage ~~ © Be. n the lesions crusted — more infective Environmental factors * Show seasonal trend * Disease occurs mostly duri months of year ’ Z * Over crowding favours i nfection mperate climate seasonal trend is less com mon » Incubation period ¢ Usually 14 to 16 days With extremes of 10 to 21 days Conti...... - When the cell mediated immunity wanes ( 1g6 or immune-suppress 2 virus get reactivated resulting in herpes zoster Clinical features of varicella IIness vary from a mild with only few scattered lesions to severe febrile illn less with widespread rash Adult chicken pox imo re sever 2 Eruptive stage 
