Coagulation Cascade Quiz
Coagulation Cascade Containing 58
Quizzes and Answers/ A+ Score
Solutions 2024.
Where do the reactions of the coagulation cascade occur? What ion do they
require? - Answer: phospholipid surface (like platelets)
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Guidelines and tips
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
58 quizzes and answers related to the coagulation cascade. It covers topics such as the reactions of the coagulation cascade, factors involved in the intrinsic and extrinsic pathways, vitamin K dependence, platelet tests, coagulation tests, and anticoagulation factors. The document also includes information on the normal reference intervals for various tests and the factors that affect platelet function. It is a useful resource for students studying hematology or related fields.
Typology: Exams
2023/2024
1 / 11
This page cannot be seen from the preview
Don't miss anything!
Related documents
Partial preview of the text
Download Coagulation Cascade Quiz and Answers and more Exams Nursing in PDF only on Docsity!
Coagulation Cascade Containing 58
Quizzes and Answers/ A+ Score
Solutions 2024.
Where do the reactions of the coagulation cascade occur? What ion do they require? - Answer: phospholipid surface (like platelets)
require Ca ions What does thrombin do? - Answer: converts soluble plasma fibrinogen into insoluble fibrin monomers which polymerize into an insoluble gel (which holds platelets together) What factor is involved in the extrinsic pathway? - Answer: Factor VII What factors are involved in the intrinsic pathway? - Answer: Factors XII, XI, IX, VIII What factors are involved in the final common pathway? - Answer: Factors X, V prothrombin fibrinogen What initiates the extrinsic pathway? How? - Answer: Tissue Factor (thromboplastin) forms a complex with factor VIIa What does the Tissue Factor:VIIa complex do? - Answer: activates factor X in common pathway (Ca needed) --> Xa What organs are high concentrations of Tissue Factor found in? - Answer: skin brain lung and placenta
What does Factor Xa do? - Answer: with the help of Factor Va and Ca, coverts prothrombin --> thrombin (IIa) What does thrombin do? - Answer: 1) fibrinogen --> fibrin
- XIII --> XIIIa
- activates VIII--> VIIIa in the intrinsic pathway What does XIIIa do? - Answer: converts soluble fibrin monomers into insoluble fibrin by enhancing the cross-linking to strengthen the fibrin clot What factor has a role in both the intrinsic and extrinsic system? - Answer: Tissue Factor What type of molecule are most coagulation factors? What are the exceptions? - Answer: serine proteases exceptions:
- V and VIII are glycoproteins and they act as cofactors
- XIII is a transglutaminase
- Fibrinogen (F I) is a soluble protein What role does Vitamin K have with coagulation factors? - Answer: gamma- carboxylates the factors which is required for binding to Ca and Tissue Factor
What factors are Vitamin K dependent? - Answer: II VII IX X anticoagulant proteins C and S Where is vitamin K made and activated? - Answer: made by bacteria in colon activated by epoxide reductase in liver What does Warfarin (and coumarins) do? - Answer: inhibits epoxide reductase so can't activate vitamin K so acts as an anticoagulant note: doesn't have immediate effect bc some g-carboxylated factors are still present. Takes 3-4 days What molecule activates the fibrinolytic system? - Answer: tPA What does tPA do? - Answer: activates plasminogen to plasmin What else can activate plasminogen to plasmin? - Answer: Factor XIIa streptokinase anistreplase urokinase like-PA
arachidonic acid EPI collagen ristocetin What measures the quantity of vWF regardless of function? - Answer: vWF antigen assay (decreaed in vW disease) What evaluates vWF function? - Answer: Ristocetin cofactor assay What are examples of coagulation tests? - Answer: PT (prothrombin time) PTT (partial thromboplastin time) Thrombin Time Which test evaluates the intrinsic pathway? - Answer: PTT Which test evaluates the extrinsic pathway? - Answer: PT What factor is primarily evaluated with the PT test? - Answer: factor VII What factor is primarily evaluated with the PTT test? - Answer: factor VIII What is the normal reference interval for PT? When is it changed? - Answer: 11- seconds prolonged if factor VII level is <30-40% of normal
What is PT used for? - Answer: 1) follow patients on warfin/coumadin for anticoagulation
- evaluate liver synthesis function (since most factors are produced in the liver)
- detect factor VII deficiency What is the normal reference interval for the PTT test? When is it changed? - Answer: 25-40 seconds prolonged when a factor level is < 30-40% of normal What factors are evaluated in the PTT test? - Answer: XII XI IX VIII** (X, V, II, and I like with PT) What is PTT used for? - Answer: 1) follow heparin therapy (bc heparin enhances ATIII activity)
- detect factor deficiencies in the intrinsic pathway ___ is used to monitor heparin therapy while ___ is used to monitor coumadin therapy. When could both be prolonged? - Answer: PTT PT
What does the FDP test do? - Answer: detects fragments associated with plasmin degradation of fibrinogen or insoluble fibrin in clots What is the most specific test for evidence of degradation of a fibrin clot (thrombus)? - Answer: D-Dimer assay What is the D-Dimer assay used for? - Answer: 1) monitoring thrombolytic therapy for coronary artery thromb.
- screen for pulmonary embolism and deep vein thrombosis
- screen for DIC What tests are included in the DIC screening panel? - Answer: PT, PTT, Platelet count, Fibrinogen, Hb/Hct, FSP, D-Dimer In patients with DIC, what will be increased? - Answer: FSP and D-Dimer What are the anticoagulation factors? Where is each made? - Answer: Antithrombin: liver Protein C: liver Protein S: liver Plasminogen: liver Tissue Factor Pathway inhibitor: endothelial cells Which Coagulant Factors aren't made in the liver? - Answer: Tissue Factor (tissue) Factor VIII (endothelial cells)
Factor XIII (platelets)