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EXEMPLAR 12.E- ADRENAL DISEASE
EXEMPLAR 12.E- ADRENAL DISEASE a — CUSHING DISEASE Vs. CUSHING SYNDROME GLUCOCORTICOIDS INCREASED CORTISOL, Na Y DECREASED K AND Ca “= - a CAUSE INCREASED SECRETION OF CORTISOL LONG-TERM USE OF GLUCOCORTICOIDS SIGNS & SYMPTOMS THE 7 3’s OF STEROIDS FATTY HUMP ROUNDED FACE THIN/BRUISING SKIN STRETCH MARKS OBESITY, DIABETES HTN, OSTEOPOROSIS q ~ = a ~ ' ia ADDISON'S DISEASE ADRENAL INSUFFICIENCY GLUCOCORTICOIDS DECREASED CORTISOL MINERALOCORTICOIDS DECREASED ALDOSTERONE \ DECREASED Na, INCREASED K, Ca / ' CAUSE » AUTOIMMUNE DYSFUNCTION STEROID WITHDRAWAL = ADRENAL GLAND DAMAGE MEDICAL CONDITIONS SURGERIES » — ® “ { SIGNS & SYMPTOMS » Hyperpigmentation Orthostatic Hypotension EKG changes, Dehydration Craving for salt, Hypoglycemia Nausea & Vomiting Abdominal pain, Diarrhea Weight loss, Weakness } V , TREATMENTS TREATMENTS » ADRENAL FLUID REPLACEMENT CORTICOSTEROID INHIBITOR ELECTROLYTE REPLACEMENT ANTICANCER OF ADRENALS MINERALOCORTICOID REPLACEMENT HYPOPHYSECTOMY \ \ GLUCOCORTICOID “ ADRENALECTOMY —* XS REPLACEMENT / 
