CONNECTIVE TISSUE
Dr. Archana Rani
Associate Professor
Department of Anatomy
KGMU UP, Lucknow
20.11.2014
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CONNECTIVE TISSUE
Dr. Archana Rani Associate Professor Department of Anatomy KGMU UP, Lucknow
20.11.
CONNECTIVE TISSUE
INTRODUCTION
Connective tissue serve as a connecting link
for binding, supporting and strengthening
all other body tissues together.
CONNECTIVE TISSUE
- Cells
- Fibres
- Ground substance
Fibroblast
- Most commonly seen ( in all types of connective tissue)
- Fusiform with slender cytoplasmic process
- Large oval nucleus
- Responsible for fiber production
- Old (inactive) cells are fibrocytes
- Contractile cells are myofibroblasts
- More at sites of wound healing
Fibroblast
Mesenchymal cells
- Undifferentiated cells
- Stellate in shape
- Cytoplasmic process
- Pluripotent cell
- Along blood vessels
Macrophages (Histiocytes)
- Free and Fixed type
Fixed Cells (histiocytes)-
- Irregular Shape
- Short branching processes
- Dark indented eccentric
nucleus,
- Derived from monocyte
- Involved in phagocytosis
- Fused to form giant cell.
Free Cells- rounded, absence
of processes
Mast cells
- Round or fusiform shaped
- Packed with coarse granules
- Present in serous membranes
- Mostly along blood vessels
- Show Metachromasia
- Granules have histamine and heparin
Leucocytes
Collagen Fibres
- White coloured when fresh
- Do not branch
- Found in abundance in bone, cartilage, tendon & ligament
- Strong, flexible & inelastic
- Present in bundle
- Collagen protein form fibres
- Fibres are composed of fibril formed by microfibrilar subunits
- Micro fibrils are made up of tropocollagen
- Synthesized by fibroblast
Synthesis of Collagen fibre
Amino acids
Procollagen
Three chains
Tropocollagen
Collagen
Elastic fibres
- Very thin but strong
- Composed of elastin protein
- Branch and anastomose freely
- Can be stretched
- Run singly & branch forming
network in loose areolar tissue
- In bundles, found in ligamentum
flava & ligamentum nuchae
- Synthesized by fibroblast
- Found in skin, ligamentum flava
& nuchae and large arteries