discussion - endocrine, Schemes and Mind Maps of Anatomy

endocrine disruptors discussion

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Tracey Blanchard
Herzing University
Unit 7 Discussion – Endocrine Disruptors
June 18, 2024
SC154-TC
Professor Ty Hoffman
Endocrine disruptors are chemicals that are either naturally or chemically made that may interfere
with, block, or act like hormones found within the endocrine system. These types of chemicals are known
to cause many different health problems. Many of these disruptors are found in everyday products that
people use but do not know that they can cause issues. The chemicals can be found in the air, diet, skin,
and water (NIEHS, 2024). The specific disruptor that will be discussed is polychlorinated biphenyls
(PCBs) this type is associated with a high risk of acquiring thyroid cancer. Polychlorinated biphenyls
(PCBs) are chemicals that are used to create electrical equipment (transformers) along with hydraulic
fluids, heat transfer fluids, lubricants, and plasticizers (NIEHS, 2024). In 1979, the government banned
using PCBs based on their high toxicity and possible threat to human and wildlife health (Alsen et al.,
2021). Even though PCBs were banned, their residue remains in the environment and may be found in
oil, cable installation, paint, plastics, and electrical items. PCBs usually occur in combinations that allow
for the PCB to affect more than one path due to having diversity within the hormone.
A wide range of studies are performed to help resolve any uncertainty surrounding these
endocrine disruptors and how they affect the endocrine system. If the chemical disruptor mimics a
hormone, it could be causing the body to overreact to the stimulus or cause it to respond at an
inappropriate moment. Examples of these possibilities include a growth hormone that may cause muscle
mass to increase or produce insulin when it is not required. Other disruptors may block a hormone from
attaching to its receptors or cause the endocrine system to stimulate or inhibit the production of hormones
seen in the under or overactive thyroid (EPA, 2024).
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Tracey Blanchard Herzing University Unit 7 Discussion – Endocrine Disruptors June 18, 2024 SC154-TC Professor Ty Hoffman Endocrine disruptors are chemicals that are either naturally or chemically made that may interfere with, block, or act like hormones found within the endocrine system. These types of chemicals are known to cause many different health problems. Many of these disruptors are found in everyday products that people use but do not know that they can cause issues. The chemicals can be found in the air, diet, skin, and water (NIEHS, 2024). The specific disruptor that will be discussed is polychlorinated biphenyls (PCBs) this type is associated with a high risk of acquiring thyroid cancer. Polychlorinated biphenyls (PCBs) are chemicals that are used to create electrical equipment (transformers) along with hydraulic fluids, heat transfer fluids, lubricants, and plasticizers (NIEHS, 2024). In 1979, the government banned using PCBs based on their high toxicity and possible threat to human and wildlife health (Alsen et al., 2021). Even though PCBs were banned, their residue remains in the environment and may be found in oil, cable installation, paint, plastics, and electrical items. PCBs usually occur in combinations that allow for the PCB to affect more than one path due to having diversity within the hormone. A wide range of studies are performed to help resolve any uncertainty surrounding these endocrine disruptors and how they affect the endocrine system. If the chemical disruptor mimics a hormone, it could be causing the body to overreact to the stimulus or cause it to respond at an inappropriate moment. Examples of these possibilities include a growth hormone that may cause muscle mass to increase or produce insulin when it is not required. Other disruptors may block a hormone from attaching to its receptors or cause the endocrine system to stimulate or inhibit the production of hormones seen in the under or overactive thyroid (EPA, 2024).

The short-term effect of PCB can be seen in skin conditions such as rashes or acne while others may see changes within the blood and urine indicating possible damage in the liver. Another short-term exposure can cause burns to the eye. Vapors found in the air may irritate the eyes and respiratory tract causing those exposed to have a sore throat, nosebleeds, hoarseness, cough, mucus, and possibly some tightness within the chest. Those who have been exposed to higher levels of PCB may present with pulmonary edema. There is a potential concern for the long-term effects of PCB but consequences are still being tested and researched. Work Cited Alsen M, Sinclair C, Cooke P, Ziadkhanpour K, Genden E, van Gerwen M. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics. 2021 Jan 19;9(1):14. doi: 10.3390/toxics9010014. PMID: 33477829; PMCID: PMC7832870. Bell MR. Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors. Curr Opin Pharmacol. 2014 Dec;19:134-44. doi: 10.1016/j.coph.2014.09.020. Epub 2014 Oct 10. PMID: 25310366; PMCID: PMC4298313. National Institute of Environmental Health Sciences. Endocrine Disruptors. NIEHS. 2024 Apr 2. Website: https://www.niehs.nih.gov/health/topics/agents/endocrine United States Environmental Protection Agency. Overview of Endocrine Disruption. 2024 Feb 22. Website: https://www.epa.gov/endocrine-disruption/overview-endcrine-disruption