Distinct Patterns of Accumulation of HSV RNA
51
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Distinct Patterns - Human Resource - Lecture Slides, Slides of Human Resource Management
Human Resource is a fundamental branch of Management Sciences. In these Lecture Slides of HRM, the Lecturer has discussed the following key concepts : Distinct Patterns, Accumulation, Terminal Acidic, Activator, Motif, Virus, Promoters, Elongation, Transcription, Stimulates Initiation
Typology: Slides
2012/2013
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Distinct Patterns of Accumulation of HSV RNA
51
VP
Potent C-terminal acidic activator
Does not bind DNA directly
- but requires a TAATGARAT motif in virus promoters
Associates with HCF and Oct- -they provide promoter specificity
Stimulates initiation and elongation of transcription
Specific for IE promoters 52
Export
A primary transcript does not become a mRNA until it is exported
Export is usually accomplished by host proteins and the transcript uses nuclear pores to exit
A protein complex that marks mature RNAs for export from the nucleus is assembled during splicing
Exportins shuttle between the nucleus and cytoplasm carrying RNA as their cargo 54
Today’s Concepts
Transcription is complicated
Control is at many levels
Host and viral proteins regulate transcription
Viral gene expression is coordinately regulated in a temporal manner 55