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Utilizing Research in Teaching Chemistry: Understanding the Role of Mitosis in Cancer, Lab Reports of Science education

Ateneo de Davao University (ADDU)Science education

Insights from two research articles that explore the significance of mitosis in cancer. The first article discusses the potential of detecting circulating tumor cells (CTCs) and their mitotic activity as a diagnostic tool for breast cancer. The second article delves into the mechanisms of Taxol, a common cancer treatment, and how cell division plays a role in its efficacy. These articles can help students expand their knowledge on cancer research and mitosis.

Typology: Lab Reports

2020/2021

Uploaded on 04/22/2022

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Gulla, Daniel C. 3SM
Javier, Allysa Kamille M.
Utilizing Research in Teaching Chemistry Journal Reading Log
Article 1: Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas
1. What basic research questions are the researchers trying to answer?
The main question researchers want to answer through this study is the effectiveness of mitosis
in circulating tumor cells towards highly aggressive breast carcinomas. It also covers how
immunohistochemical fluorescence stains improves the prognostic utility of patient’s survival
rate.
2. What makes the research question significant?
The research question is significant because it proves how effective this new biochemical
technique is compared to the different former methods. It helps the readers understand how
mitosis in various cells can help in stratifying patients beyond general protocols.
3. What is the sampling technique used by the researchers?
The sampling technique that was used in this study is simple random sampling where various
respondents have been selected from an overall number of patients.
4. Who and How many are the respondents?
The respondents are a total of 30 patients with late-stage breast cancer over 24 months.
5. Describe the assessment tool used by the researchers?
The assessment tool used in this study is trough single-blind prospective. The respondents was
selected from 36 patients that depicted breast cancer for two years to assess overall survival
between simple CTC enumeration and subtyping mitotic CTCs. According to a power study (1- =
0. 9, 0.05), a pilot size of 30 patients was sufficient to stratify this patient cohort; 36 patients
were included in total.
6. What data did the researchers collect?
The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients
has the potential to be a therapeutically useful, less invasive diagnostic tool. To strengthen their
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Gulla, Daniel C. 3SM Javier, Allysa Kamille M. Utilizing Research in Teaching Chemistry Journal Reading Log Article 1: Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas

  1. What basic research questions are the researchers trying to answer? The main question researchers want to answer through this study is the effectiveness of mitosis in circulating tumor cells towards highly aggressive breast carcinomas. It also covers how immunohistochemical fluorescence stains improves the prognostic utility of patient’s survival rate.
  2. What makes the research question significant? The research question is significant because it proves how effective this new biochemical technique is compared to the different former methods. It helps the readers understand how mitosis in various cells can help in stratifying patients beyond general protocols.
  3. What is the sampling technique used by the researchers? The sampling technique that was used in this study is simple random sampling where various respondents have been selected from an overall number of patients.
  4. Who and How many are the respondents? The respondents are a total of 30 patients with late-stage breast cancer over 24 months.
  5. Describe the assessment tool used by the researchers? The assessment tool used in this study is trough single-blind prospective. The respondents was selected from 36 patients that depicted breast cancer for two years to assess overall survival between simple CTC enumeration and subtyping mitotic CTCs. According to a power study (1- =
  6. 9, 0.05), a pilot size of 30 patients was sufficient to stratify this patient cohort; 36 patients were included in total.
  7. What data did the researchers collect? The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients has the potential to be a therapeutically useful, less invasive diagnostic tool. To strengthen their

predictive value in connection to survival, we superimpose the approaches, cytologically subtyping CTCs tagged with immunohistochemistry fluorescent stains.

  1. What is the researchers' interpretation of their data? The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients has the potential to be a therapeutically useful, less invasive diagnostic tool. To strengthen their predictive value in connection to survival, we superimpose the approaches, cytologically subtyping CTCs tagged with immunohistochemistry fluorescent stains.
  2. Do you think that the data collected support their conclusion? Why or why not? Yes the data collected support their conclusion as you can see they suggested that they should believe that following mitotic cancer cells as they travel through the circulatory system is a straightforward, noninvasive way to acquire clinical information on highly aggressive tumor cells and may help with treatment planning as the disease progresses.
  3. Do you think the developed assessment/survey instrument would be applicable to Filipino students? Why? Yes, it would be applicable and appropriate for Filipino students to use this kind of research paper to further improve the knowledge and information of the student relating to cancer and mitosis. Thus the assessment/survey that was used was Blood sample collection, CellSieve™ low-flow microfiltration procedure, Enumerating CTCs, and Grading mitotic proliferation although they are not yet well aware of this assessment thus students can learn from the said words in order for them to expand their knowledge pertaining to different type of surveys whether written on a piece of paper or doing it physically with proper procedure. 10.. If you become a teacher, how will the data from this research help you in teaching? Teachers have been provided answers to questions they didn't ask and solutions to problems that never existed." It is critical to get a thorough grasp of educational research, including its scope and limits. It's not a case of "anything goes" or "anything works for me." When I become a professor, this research data may assist me in teaching the concept of what learning is and applying it to their learning journey, not everything must be given to us thus we must find ways to explore and learn more of what the world has not yet shown us. Remember that this study is about mitosis and how it can help prevent or remove cancer. How this research will become more efficient and effective not only to yourself but for the whole world in the future. Adams, D. L. (2016, 4 mei). Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas - Breast Cancer Research. BioMed Central. Geraadpleegd op 27 maart 2022,

can perish. Cells missing cGAS, on the other hand, were able to withstand the treatment by entering a condition known as slippage. This difference in reaction to the chemical might have significant medical ramifications. How this data may lead to a new therapeutic method that will help Taxol function better in those who wouldn't react to it otherwise.

  1. Do you think that the data collected support their conclusion? Why or why not? Yes, it has supported their conclusion because they have had the idea on how cells would react to taxol. Paclitaxel is the scientific term for Taxol, wherein It is used to treat a variety of cancers. If those findings are correct, cGAS appears to be an important component of Taxol's capacity to kill cancer cells wherein the researchers are now attempting to ascertain if the link is causal, how cGAS levels may truly boost therapeutic efficacy and to demonstrate that the mechanism they discovered in cells and mice also applies to humans.
  2. Do you think the developed assessment/survey instrument would be applicable to Filipino students? Why? Yes, the developed assessment/survey instrument would be applicable to Filipino students because as a country that is on the verge of wanting to improve for the future, Filipino students, being filipino themselves tend to learn from their mistakes even though we can say that having cancer is not a mistake rather it is sometimes determine by God we can say that as students and maybe future doctors we want to bring out the best in ourselves thus this developed assessment instrument may be a key to that factor and also this research about cancer can be prior to initiating a research project about what there is to come. 10. If you become a teacher, how will the data from this research help you in teaching? If I become a teacher, the data from the research may help me in such a way that I could teach the idea of what has been learned in the research and how this study will be more efficient in the long run. How I could encourage my students to apply approaches based on spaced practice and dual coding, rather than merely re-reading and marking notes, which is used to analyze evidence-informed treatments and determine what works. Specifically, how the researchers aim to heal and cure cancer which is the main idea for conducting the research. Research on cell division provides new clues to how a common cancer treatment works. (2021, 20 januari). News. Geraadpleegd op 26 maart 2022, van https://www.rockefeller.edu/news/26631-research-cell-division-provides-new-clues- common-cancer-treatment-works/

Article 3 : Anti-mitotic therapies in cancer

  1. What basic research questions are the researchers trying to answer? The main question researchers want to answer through this study is how cancer therapies target key pathways to drive and execute cell division. This then covers the question how does somatic cell division cycle culminates in mitosis.
  2. What makes the research question significant? The research question is significant because
  3. What is the sampling technique used by the researchers? The sampling technique that was used in this study is simple random sampling where
  4. Who and How many are the respondents? The respondents in this study are said to be various patients have been selected to perform preclinical results and clinical performance of anti-mitotics.
  5. Describe the assessment tool used by the researchers? The ensuing mitotic delay, abortive mitosis, or abnormal chromosome segregation can trigger a range of cellular stresses. Cellular response to these stresses appears to be stochastic, since the fate of individual cells receiving the treatment in the same dish varies. Some undergo mitotic catastrophe (mitotic cell death) and some exit mitosis with subsequent arrest or death in G1, whereas others continue cycling (4, 5).
  6. What data did the researchers collect? Highly selective mitotic inhibitors cannot reproduce multifaceted anticancer effects and how enhanced pharmacodynamics and pharmacokinetics with the creation of predictive biomarkers from clinical trial data might improve effectiveness of anti-mitotic therapies in cancer.
  7. What is the researchers' interpretation of their data? The researchers' interpretation was that it induces cell death by causing widespread chromosomal missegregation, which may lead to better clinical outcomes. How new molecules might be developed with changes unique to malignancy, such as centrosome amplification or Mps1 (a component of the SAC) overexpression Mps1 inhibitors, unlike the previous class of antimitotics, do not prevent mitosis.