PHA 5127
Case Study 5
Fall 2007
SET I:
True or False
T F 1: A one compartment model means that drug in the blood is in rapid equilibration
with drug in extravascular tissues.
T F 2: For a linear model, the rate constant for elimination is not proportional to the
amount of drug remaining to be eliminated.
T F 3: Clearance and volume of distribution are independent each other, but both of
them are dependent of dose.
T F 4: A drug with a linear protein binding has linear pharmacokinetics.
T F 5: In a linear one-compartmental model, lower dose and lower volume of
distribution result in a lower initial drug concentration after a single IV bolus.
T F 6: In a linear one-compartmental model, any two concentration points in
concentration-time profile can determine drug half-life after a single IV bolus.
T F 7: Total clearance is always greater or equal to renal clearance.
SET II:
Jane, 5’8”, 35-year-old, is being treated with the new drug for an infection disease. Jane weights
64.4 kg. Cpcreat in Jane is 0.8 mg/dL Assume a Vd of 0.24 L/kg*(TBW), and clearance of this
drug is equal to creatinine clearance, and this drug follows a linear one compartment model.
1. In order to achieve initial concentration 6 mg/L, please calculate this IV bolus dose.
2. Calculate half-life of this drug, and how many half-lives will it take to drop concentration
from 6 mg/L to 750 µg/mL?
