Review of Basic Principles of Pharmacology
Objectives
1. Identify the factors influencing drug responses
2. Describe drug-receptor binding
3. Explain the 4 processes of pharmacokinetics: absorption, distribution, metabolism, and e
excretion
Overview
Pharmacology—the study of drugs
Drug responses
Receptors
Pharmacokinetics
Summary
Pharmacology
- Study of drugs and their actions
- Ideal drug properties: Convenient administration and duration of action
Established dosage
Immediate onset of action
Produces a single desired biological action
Dosage unaffected by disease state
Improves longevity and quality of life
Drug Responses
Dose–response curves
Types of drug responses
Expressing drug responses
Drug selectivity
Drug responses in the real world
Brand versus generic drugs
Dose–Response Curves
Dose–response curve depicts the relationship between drug dose and the magnitude of effect
Doses below the curve do not produce a pharmacological response
Doses above the curve do not produce much additional pharmacological response
May have unwanted effects → _t_o_x_i_c_i_t_y_
