Endocrine System -Training Handout, Lecture notes of Nutrition

Endocrine glands are told to produce less of a hormone by substances in the blood or by the very hormone the gland is about to stop producing a large amount of.

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Endocrine System -Training Handout
Karen L. Lancour
National Rules Committee Chairman – Life Science
The endocrine system is a chemical control system. It functions in conjunction with the nervous system to
control the internal environment (homeostasis).
Nervous System vs. Endocrine System – both systems enable cells to communicate with other by using
chemical messengers.
Nervous System Endocrine System
Chemical Messenger neurotransmitters hormones
Location of message synapses target cells
Effects rapid & short-lasting slower & longer lasting
Controls muscles & glands activities of cells
o
Type of Glands
Endocrine Glands – discharge
secretions through a duct to a targeted
tissue such as digestive glands
Endocrine Glands – release secretions
directly into the blood stream so they
are ductless.
o The secretions are chemical
messengers or hormones
o Each hormone has a specific
target tissue which may
increase or decrease its activity
such as insulin
o They are not secreted at a
constant rate – the rate will
vary with the needs of the
body
Endocrine Glands
The endocrine system is in charge of
processes that happen slowly, such as the
growth of cells.
The glands and hormones of the endocrine system influence almost every cell and organ in the body
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Endocrine System - Training Handout

Karen L. Lancour National Rules Committee Chairman – Life Science The endocrine system is a chemical control system. It functions in conjunction with the nervous system to control the internal environment (homeostasis). Nervous System vs. Endocrine System – both systems enable cells to communicate with other by using chemical messengers. Nervous System Endocrine System Chemical Messenger neurotransmitters hormones Location of message synapses target cells Effects rapid & short-lasting slower & longer lasting Controls muscles & glands activities of cells o Type of Glands

  • Endocrine Glands – discharge secretions through a duct to a targeted tissue such as digestive glands
  • Endocrine Glands – release secretions directly into the blood stream so they are ductless. o The secretions are chemical messengers or hormones o Each hormone has a specific target tissue which may increase or decrease its activity such as insulin o They are not secreted at a constant rate – the rate will vary with the needs of the body Endocrine Glands
  • The endocrine system is in charge of processes that happen slowly, such as the growth of cells.
  • The glands and hormones of the endocrine system influence almost every cell and organ in the body

ENDOCRINE SYSTEM AND HOMEOSTASIS

Homeostasis – a stable internal environment - (nutrition, metabolism, excretion, water and salt balances). Feedback Mechanisms Stimulus o change in homeostatic environment o signal sent to CNS Response o signal sent from CNS o produce effect & body returns to homeostasis Hormones are the body’s chemical messenger.

  • They send important information from one set of cells to another.
  • Each hormone only affects cells that are programmed to receive a specific hormone’s message.
  • Glands are groups of cells that produce chemical products for our body to use.
  • For example, salivary glands produce saliva.
  • Once hormone levels reach a certain amount, endocrine system glands will produce less of a specific hormone.
  • Endocrine glands are told to produce less of a hormone by substances in the blood or by the very hormone the gland is about to stop producing a large amount of.
  • Most hormones use a “turnoff” process is called a negative feedback or a closed loop system.

Glands of the Endocrine System

  • Hypothalmus: o Also part of the brain, attached to the posterior pituitary gland o Its function is to synchronize the information from the brain and the secretions of hormones o Neurosecretory cells – specialized neurons that synthesize & secrete hormones o The hypothalamus controls the secretions of the pituitary gland through nervous stimulation (posterior pituitary) and releasing hormones secreted to the anterior pituitary o Neuronal to POSTERIOR PITUITARY o Endocrine to ANTERIOR PITUITARY RH = Pituitary releasing hormones RIH = Pituitary release inhibiting hormones
  • Pituitary: o Located at the base of the brain and is no larger than the size of a pea. o Considered the most important part of the endocrine system and is often called the “ master gland ”. o Controls many other endocrine system glands. The pituitary gland helps control body and tissue growth. o Also secretes endorphins, chemicals that reduce sensitivity to pain. o Divided into anterior and posterior sections
  • Anterior Pituitary: o This is considered the master gland because its secretions regulate many other glands o It secretes: o Follicle stimulating hormone (FSH) and luteinizing hormone (LH) which regulate production of estrogen and progesterone o Thyroid stimulating hormone (TSH) which stimulates the thyroid to release thyroxin o Adreno-corticotropic hormone (ACTH) which stimulates release of chemicals from the adrenal cortex o Growth hormone (GH) stimulate cell growth o Melanocyte-stimulating hormone (MSH) which increases production of the skin pigment melanin o Prolactin stimulates production of milk in nursing mothers
  • Parathyroid: o These four little glands are embedded in the thyroid gland o They secrete parathyroid hormone which regulates the amount of calcium in the blood and its absorption by bones
  • Thymus: o Located below the thyroid between the right and left lung o Secretes thymosin which stimulates T-cell (that is a type of white blood cell) production in children. o This gland shrinks with age as we are exposed to more germs and build up our stores of antibodies
  • Adrenal: o There are two located on top of the kidneys o Medulla secretes epinephrine (adrenaline) and norepinephrine which regulate our fight or flight response at times of extreme stress o Cortex secretes aldesterone which regulates reabsorption of nutrients from the kidney o It also secretes cortisol which controls the rate of metabolism of carbohydrates, fats, and proteins
  • Pancreas: o Located behind the right side of the stomach o Secretes insulin which tells the liver and muscles to remove sugar from the blood and store it as fat o Also secretes glucagon which tells the liver to break down fat stores and release sugar back into the blood
  • Ovaries: o Secrete estrogen and progesterone which regulate the female menstrual cycle o Endometrium in the uterus also secretes a female hormone when a fertilized egg binds to it to stop the menstrual cycle from progressing to menstruation
  • Testicles: o Secretes male steroid hormones such as testosterone. o Testosterone controls development of male characteristics such as formation of male sex organs in the womb, sperm development, and secondary sex characteristics at puberty (deep voice, facial hair, chest and armpit hair, etc) ENDOCRINE SYSTEM DISORDERS
    • Hyper = secretion of too much hormone
    • Hypo = secretion of insufficient hormone
    • Target cell insensitivity produces symptoms similar to hyposecretion. Pituitary Gland Disorders:
  • Pituitary dwarfism = hyposecretion of GH
  • Giantism = hypersecretion of GH during childhood
  • Acromegaly = hypersecretion of GH during adulthood
  • Diabetes insipidus = hyposecretion of ADH which causes excretion of large amounts of dilute urine and subsequent dehydration and thirst Thyroid Gland Disorders:
  • Cretinism = hyposecretion of thyroid hormones during fetal life or infancy.
  • Myxedema = hypothyroidism during adult years
  • Grave's Disease = an autoimmune disease which is the most common form of hyperthyroidism
  • Goiter = enlarged thyroid gland Parathyroid Gland Disorders:
  • Hypoparathyroidism results in muscle tetany
  • Hyperparathyroidism produces osteitis fibrosa cystica which results in demineralization of the bone. Adrenal Gland Disorders:
  • Cushing's Syndrome = hypersecretion of cortisol by the adrenal cortex
  • Addison's Disease = hyposecretion of glucocorticoids and aldosterone
  • Tumors of the adrenal medulla can cause hypersecretion of medullary hormones and a prolonged "fight or flight" response. Pancreatic Disorders:
  • Diabetes mellitus = a group of disorders caused by an inability to produce or use insulin
  • Type I or insulin - dependent diabetes mellitus is caused by an absolute deficiency of insulin
  • Type II or insulin-independent diabetes is caused by down-regulation of insulin receptors
  • Hyperinsulinism results when too much insulin is present and causes hypoglycemia (low blood sugar) and possibly insulin shock.

Classes of Hormones: (Division C)

peptides – short chains of amino acids (most hormones) pituitary, parathyroid, heart, stomach, liver & kidneys amines - derived from tyrosine and secreted by thyroid and adrenal cortex steroids - lipids derived from cholesterol secreted by the gonads, adrenal cortex, and placenta eicosanoid - produced from 20-carbon fatty acid, arachadonic acid, produced in all cells except RBCs - Prostaglandins and leukotrienes Peptide/Protein

  • Hydrophilic
  • Large
  • Can't fit through membrane
  • Second messenger mechanism of action
  • Most common hormone
  • translated, packaged, & sent
  • Hydrophilic/Lipophobic
  • Bind surface receptors at target
  • Binding mediates signal transduction/2nd messenger system
  • Example: Insulin Amine
  • Synthesized from a single amino acid
  • Melatonin from tryptophan
  • Thyroid hormone from tyrosine
  • Catecholamines (EPI, DA) from tyrosine Eicosanoid
  • Produced from 20-carbon fatty acid, arachadonic acid
  • Produced in all cells except RBCs
  • 2nd messenger
  • Prostaglandins and leukotrienes
  • inflammation Steroid Hormones
  • Small
  • Hydrophobic/Lipophilic
  • Travel in blood w/carrier
  • Cytoplasmic or nuclear receptors
  • change protein synthesis
  • Example: estradiol