Equilibrium Potential and Resting Membrane Potential (RMP) in Neurons, Exams of Advanced Education

A concise overview of equilibrium potential and resting membrane potential (rmp) in neurons. It explains key concepts such as the roles of dendrites and axons, uphill vs. Downhill gradients, and the balance between chemical and electrical forces. The document also includes the nernst equation and the goldman-hodgkin-katz equation, along with normal ion concentration values. This information is crucial for understanding neuronal function and cellular communication, making it a valuable resource for students studying neuroscience, physiology, and related fields. The document offers a clear explanation of electrochemical equilibrium and its importance in maintaining neuronal stability and function.

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2024/2025

Available from 11/09/2025

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Equilibrium Potential and RMP
The Neuron - correct answer Is compartmentalized
Dendrite and soma are responsible for receiving the input signals
Axons are responsible for sending out the signals to the terminals
Uphill vs. Downhill gradient - correct answer Uphill= active, consumes body's
energy ATP
Downhill= passive, does not consume body's energy (no ATP used)
Equilibrium potential - correct answer When electrical force (diffusion potential)
increases to the point that it exactly balances or opposes the chemical force
(tendency for ion to go down its concentration gradiant)
Has 2 forces acting on it
Chemical force= the concentration of the ion
Electrical force= the charge of the ion
These forces, once the become equal, will act to repel each other so that no more
net flow of the ion will cross a semi-permeable membrane
Electrochemical equilibrium - correct answer Chemical and electrical driving forces
acting on an ion are equal and opposite and there is not further net diffusion of the
ion
Nernst Equation - correct answer Describes the equilibrium potential for any ion
species
E= RT/zF x ln [C]o/[C]i
E=61/z X Log[C]o/[C]i
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Equilibrium Potential and RMP

The Neuron - correct answer Is compartmentalized Dendrite and soma are responsible for receiving the input signals Axons are responsible for sending out the signals to the terminals Uphill vs. Downhill gradient - correct answer Uphill= active, consumes body's energy ATP Downhill= passive, does not consume body's energy (no ATP used) Equilibrium potential - correct answer When electrical force (diffusion potential) increases to the point that it exactly balances or opposes the chemical force (tendency for ion to go down its concentration gradiant) Has 2 forces acting on it Chemical force= the concentration of the ion Electrical force= the charge of the ion These forces, once the become equal, will act to repel each other so that no more net flow of the ion will cross a semi-permeable membrane Electrochemical equilibrium - correct answer Chemical and electrical driving forces acting on an ion are equal and opposite and there is not further net diffusion of the ion Nernst Equation - correct answer Describes the equilibrium potential for any ion species E= RT/zF x ln [C]o/[C]i E=61/z X Log[C]o/[C]i

T= 37C +273.15= 310.

R= 8.2 joules/mol K F= 96,599 coulombs/mol Z= valence ion number Goldman- Hodkin-Katz equation - correct answer Vrest= 61 log10 [Na]oP + [K]oP + [cl]iP////// [Na]iP + [K]iP + [cl]0P Resting membrane potential - correct answer Is -70mV The inside of the cell is more negative than the outside of the cell Na concentration Normal values - correct answer Inside the cell= 14mM/L Outside= 142mM/L K concentration Normal values - correct answer Inside= 140mM/L Outside= 4.2 mM/L