Docsity
Docsity
Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity

Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan

Guidelines and tips
Guidelines and tips
Sell on Docsity
Sell on Docsity
Docsity AI
Docsity AI
Log inSign up

Prepare for your exams

Study with the several resources on Docsity

Find documents

Prepare for your exams with the study notes shared by other students like you on Docsity

Search for your university

Find the specific documents for your university's exams

Docsity AINEW

Summarize your documents, ask them questions, convert them into quizzes and concept maps

Explore questions

Clear up your doubts by reading the answers to questions asked by your fellow students

Earn points to download

Earn points by helping other students or get them with a premium plan

Share documents
download point icon20 Points

For each uploaded document

Answer questions
download point icon5 Points

For each given answer (max 1 per day)

All the ways to get free points
Get points immediately

Choose a premium plan with all the points you need

Study Opportunities

Choose your next study program

Get in touch with the best universities in the world. Search through thousands of universities and official partners

Community

Ask the community

Ask the community for help and clear up your study doubts

Free resources

Our save-the-student-ebooks!

Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors

Pharmacokinetics Exam, Fall 1997, Exams of Health sciences

University of Florida (UF)Health sciences

A pharmacokinetics exam from a university course held in fall 1997. The exam covers various topics such as drug distribution, plasma protein binding, volume of distribution, clearance, and elimination rate. Students are required to answer multiple-choice questions and perform calculations based on provided information.

Typology: Exams

Pre 2010

Uploaded on 03/10/2009

koofers-user-7eo
koofers-user-7eo 🇺🇸

10 documents

1 / 6

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
Name:________________________
SS#: _________________________
PHA 4120
First Exam
Fall 1997
On my honor, I have neither given nor received unauthorized aid in doing this assignment.
Name
Question/Points
1. ___________/5
2. ___________/12
3. ___________/5
4. ___________/4
5. ___________/5
6. ___________/10
7. ___________/10
8. ___________/10
9. ___________/8
10. ___________/9
1
pf3
pf4
pf5

Partial preview of the text

Download Pharmacokinetics Exam, Fall 1997 and more Exams Health sciences in PDF only on Docsity!

SS#: _________________________

PHA 4120

First Exam

Fall 1997

On my honor, I have neither given nor received unauthorized aid in doing this assignment.

Name

Question/Points

  1. ___________/
  2. ___________/
  3. ___________/
  4. ___________/
  5. ___________/
  6. ___________/
  7. ___________/
  8. ___________/
  9. ___________/
  10. ___________/

SS#: _________________________

  1. The volume of distribution of a drug X is 40,000 L. Indicate which one of the following statements is (are) consistent with this observation (5 pts)

A ____ plasma protein binding is more pronounced than tissue binding

B ____ highly metabolized in the tissue

C ____ the drug does not leave the plasma

D ____ not at all bound to plasma proteins

E ____ drug is able to cross membranes

  1. For each fluid below give the approximate volume you would expect in an adult person (12 pts) - Extracellular fluid - Total body water - plasma

SS#: _________________________

limitations. Which of the two drugs will enter the brain faster (short explanation) ( pts)

  1. Mark whether the following statements are True or False (5 pts)

T F Drugs which are very lipophillic tend to distribute well into body tissues.

T F Lipophilic drugs with a high Kp value have a large volume of distribution.

T F The volume of distribution depends on the ability of the drug to pass membranes and the degree of plasma and tissue binding.

T F The extraction ratio for a high extraction drug is independent of the plasma protein binding.

T F The extraction ratio for a low extraction drug is independent of the tissue protein binding.

  1. Explain the term clearance in your own words (no equations). Do not use more than 30 words. (10 points)

SS#: _________________________

  1. You have a lipophilic, protein bound, low extraction drug. Indicate what pharmacokinetic parameter will be changed by the following physiological changes. Mark also whether the selected parameters will increase or decrease. List only one parameter per item (8 points)

increase in plasma protein binding.....................................

increase in liver blood flow.....................................

increase in the “number of fat cells” .....................................

increase in the number of metabolizing enzymes.....................................

  1. A drug is given as an IV bolus injection. The initial plasma concentration was 80 μg/ml. 3 hours later the plasma concentration was 40 μg/ml. What is the plasma concentration 6 hours after dosing if (10 pts)

a) the elimination is first order?

b) the elimination is zero-order?