Genetic Diversity and Mutations, Summaries of Biology

Genetic Diversity and Mutations - A level AQA Biology

Typology: Summaries

2025/2026

Uploaded on 05/30/2026

shiv-31
shiv-31 🇬🇧

9 documents

1 / 3

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
3.4.3 Genetic diversity can arise as a result of
mutation or during meiosis
Genetic variation can be introduced in many ways, such as:
1) Meiosis
2) Mutations
3) Random fertilisation of gametes
Meiosis
Meiosis produces 4 haploid daughter cells that are genetically different to each other
(unique). There are 2 nuclear divisions- 4 haploid daughter cells from 1 parent cell.
In the first division (meiosis I) - homologous chromosomes are separated - these are the
pair of chromosomes you inherit - one from each parent - they are the same type of
chromosome - same gene but may be different versions of the gene - same gene loci .
In the second division (meiosis II) - the sister chromatids of each chromosomes are
separated
First division - homologous chromosomes separate
Second division - sister chromatids separate
You do not need to know about PMAT here, only about how genetic variation is introduced!
(phew…)
There are 2 main mechanisms through which this occurs (both occur in meiosis I):
1) Independent segregation of homologous chromosomes
In meiosis I, homologous pairs of chromosomes line up opposite to each other at the
equator of the cell. Which side of the equator the paternal and maternal
chromosomes line up is random however homologous pairs are next to each other.
These pairs are separated so that one of each homologous pair ends up in the the
daughter cell - each daughter cell is genetically unique
Different combinations of maternal paternal chromosomes so a mix of different
alleles for different genes
2^n → where n is the number of homologous pairs. This is used to
calculate the number of possible combinations of chromosomes in the
daughter cell produced
Square this number to find the amount of combinations when male and female
gametes combine
2) Crossing over between homologous chromosomes
This introduced further genetic variation.
pf3

Partial preview of the text

Download Genetic Diversity and Mutations and more Summaries Biology in PDF only on Docsity!

3.4.3 Genetic diversity can arise as a result of

mutation or during meiosis

Genetic variation can be introduced in many ways, such as:

  1. Meiosis
  2. Mutations
  3. Random fertilisation of gametes

Meiosis

Meiosis produces 4 haploid daughter cells that are genetically different to each other (unique). There are 2 nuclear divisions- 4 haploid daughter cells from 1 parent cell. In the first division (meiosis I) - homologous chromosomes are separated - these are the pair of chromosomes you inherit - one from each parent - they are the same type of chromosome - same gene but may be different versions of the gene - same gene loci. In the second division (meiosis II) - the sister chromatids of each chromosomes are separated First division - homologous chromosomes separate Second division - sister chromatids separate You do not need to know about PMAT here, only about how genetic variation is introduced! ( phew… ) There are 2 main mechanisms through which this occurs (both occur in meiosis I):

1) Independent segregation of homologous chromosomes

In meiosis I, homologous pairs of chromosomes line up opposite to each other at the equator of the cell. Which side of the equator the paternal and maternal chromosomes line up is random however homologous pairs are next to each other. These pairs are separated so that one of each homologous pair ends up in the the daughter cell - each daughter cell is genetically unique Different combinations of maternal paternal chromosomes so a mix of different alleles for different genes 2^n → where n is the number of homologous pairs. This is used to calculate the number of possible combinations of chromosomes in the daughter cell produced Square this number to find the amount of combinations when male and female gametes combine

2) Crossing over between homologous chromosomes

This introduced further genetic variation.

  1. Homologous pairs line up and form a bivalent (this is just them next to each other essentially)
  2. The non-sister chromatids (from different homologous chromosomes in a pair) entangle and chiasmata form at points where they touch and twist
  3. This causes equal lengths of chromatids to break off - they can then rejoin with the chromatids of its homologous partner
  4. This leads to new combinations of alleles on chromatids This is called crossing over AND recombination. Random fertilisation of random gametes further increases variation. This is because each egg and sperm cell has gone through independent segregation and crossing over so they are both genetically unique and quite different from each other. After fertilisation, a new combination of alleles are created with different homologous pairs which increases variation
  • all sperm and all eggs are different to one and another due to meiosis - this is further enhanced by sexual reproduction When there are too few or too many chromosomes sterile offspring are created : this is because there are extra sets of chromosomes (e.g 2 maternal and 1 paternal instead of 1:1) so homologous chromosomes do not pair up or won’t separate evenly - this means meiosis does not occur.

Identifying meiosis

YOU MUST look for a diploid parent cell dividing to become a haploid daughter cell (2n → n) It may not always be the formation of gametes -different organisms have different processes.

Gene mutation

Gene mutations involve a change in the base sequence of the DNA in chromosomes - these randomly occur during DNA REPLICATION. They include base deletion or base substitution (later on you will learn more but for AS and paper 1 this is enough) Random mutations are more likely to occur if there has been an exposure to mutagenic agents:

  • High energy radiation
  • Ionising radiation
  • Chemicals such as carcinogens They increase the rate of gene mutation