Glycogen Metabolism Notes, Lecture notes of Medical Biochemistry

this contains few notes regarding glycogen metabolism

Typology: Lecture notes

2022/2023

Available from 07/03/2023

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Glycogen Metabolism: Activity (Notes)
Write the structural formula of the following:
1. Glycogen
C24H42O21
2. Uridine Diphosphate (UDP)
C9H14N2O12P2
3. Uridine Triphosphate (UTP)
C9H15N2O15P3
4. Glucagon
C153H225N43O49S
5. Alpha 1,4 glycisidic bonds
C12H22O11
6. Hexokinase- Glucose+ATP -> GGP+ADP
H6380
7. Glycogenin
C24H42O21
8. Glucose 1 phosphate
C6H13O9P
9. Uridine diphosphate glucose
C15H24N2O17P2
10.Alpha 1,6 glycosidic bonds
(C6H10O5)n
I. DEFINE:
1. Glycosidic bonds-
Covalent chemical bonds that hold together a glycoside. Glycoside is
composed of sugar molecules.
2. Uridine diphosphate (UDP)
A nucleotide diphosphate that facilitates metabolism and secretion of toxic
xenobiotics, carcinogens, estrogens, bilirubin, and therapeutic drugs.
3. Glycogenin
An enzyme involved in the conversion of glucose to glycogen.
Acts as a primer for glycogen synthesis and self-glycosilating enzyme that
uses UDP
4. Phosphoglucomutase-
An enzyme that catalyzes the interconversion of glucose 1-phosphate and
glucose 6 phosphate via glucose 1-6 phosphate intermediate
Key enzyme in glycolysis and gluconeogenesis
5. Pyrophosphorylase-
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Glycogen Metabolism: Activity (Notes) Write the structural formula of the following:

1. Glycogen  C 24 H 42 O 21 2. Uridine Diphosphate (UDP) C 9 H 14 N 2 O 12 P 2 3. Uridine Triphosphate (UTP)  C 9 H 15 N 2 O 15 P 3 4. Glucagon  C 153 H 225 N 43 O 49 S 5. Alpha 1,4 glycisidic bonds  C 12 H 22 O 11 6. Hexokinase- Glucose+ATP -> GGP+ADP  H 6380 7. Glycogenin  C 24 H 42 O 21 8. Glucose 1 phosphate  C 6 H 13 O 9 P 9. Uridine diphosphate glucose  C 15 H 24 N 2 O 17 P 2 10. Alpha 1,6 glycosidic bonds  (C 6 H 10 O 5 )n I. DEFINE: 1. Glycosidic bonds  Covalent chemical bonds that hold together a glycoside. Glycoside is composed of sugar molecules. 2. Uridine diphosphate (UDP)  A nucleotide diphosphate that facilitates metabolism and secretion of toxic xenobiotics, carcinogens, estrogens, bilirubin, and therapeutic drugs. 3. Glycogenin  An enzyme involved in the conversion of glucose to glycogen.  Acts as a primer for glycogen synthesis and self-glycosilating enzyme that uses UDP 4. Phosphoglucomutase  An enzyme that catalyzes the interconversion of glucose 1-phosphate and glucose 6 phosphate via glucose 1-6 phosphate intermediate  Key enzyme in glycolysis and gluconeogenesis 5. Pyrophosphorylase

 An enzyme involved in carbohydrate metabolism.

6. Glycogenin  An enzyme involved in converting glucose to glycogen (Acts as a primer) 7. Glycogen synthase  An enzyme present in liver and muscle cells that catalyzes the production of glycogen in the skeletal muscle. 8. Epinephrine, then give the function  A hormone and a neurotransmitter used to treat allergic reactions, cardiac rhythm, and control mucosal congestion  It is a common medication used for emergency treatment to allergic reactions 9. Glycogen phosphorylase  Key enzyme responsible for the first step in of glycogenolysis  Catalyzes the sequential phosphorolysis of glycogen to release glucose- phosphate 10.Adenyl cyclase  An enzyme used to synthesize cylic AMP which regulates diverse physiological responses including sugar and lipid metabolism, olfaction, cell growth and differentiation. 11.Glucose pyrophosphorylase  An enzyme involved in carbohydrate metabolism. 12.Tyrosine kinase receptor  Protein involved in cell-to-cell communication, cell growth, motility, differentiation, and metabolism 13.G-protein couple receptor  transmit extracellular signals across the plasma membrane via intracellular activation of heterotrimeric G proteins II. 1. Where do epinephrine secreted and give the function.  Secreted in the Medulla of our adrenal glands in response to stress.  Primarily to increase cardiac output and raise the glucose levels in the blood. It relaxes the airways and tightens the blood vessels. 2. Glucose-6- phospahase  An enzyme found in the liver and the kidneys that functions as a provider of glucose during starvation  An enzyme associated with endoplasmic reticulum. 3. Where do insuline bind?

 Insulin binds to the insulin receptor found on the plasma membrane and

activates signaling cascades to regulate metabolism and cell growth.

4. Where do glucagon bind?  Glucagon binds with its receptor which is mainly found in the liver and kidney.