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GPAT MCQ questions for Pharmacy, Exams of Pharmacy

Guru Nanak Dev UniversityPharmacy

GPAT MCQ questions for Pharmacy Old paper

Typology: Exams

2018/2019

Uploaded on 09/10/2019

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MODEL PRE-GPAT QUESTION PAPER WITH
ANSWERS KEY
1.Which of the following anti-arrhythmic drug is having Iodine?
a. Disopyramide b. Flecainide c. Amiodarone d. Quinidine
2. The quality of Coca leaves is mainly dependent on which of the following
constituents?
a. Cocaine b. Truxilline c. Ecgonine d. Cinnamyl cocaine
3. CH3O- Na+ + CH3Cl - CH3 - O - CH3 + NaCl
The above reaction is an example for which of the following?
a. Williamson reaction b. Clemmenson reaction
c. Wuotz's reaction d. Reformatsky reaction
4. Which of the following gelatine concentration is used to determine the viscosity of
gelatine used for the preparation of soft gelatine capsules?
a. 6 2/3 % b. 7 2/3% c. 5 2/3 % d. 6 3/4%
5. Which of the following group is detected by using Herzig Meyer method?
a. Alkyl group b. Hydroxy group c. Alkoxy group d. N-alkyl group
6. Which of the following drug blocks the sodium channel and dissociates slowly?
a. Quinidine b. Lignocaine c. Flecainide d. Procainamide
7. According to Drugs and Cosmetics act, List of substances that should be sold by retail
only on prescription of registered medical practitioner is given in which of the following
Schedule?
a. Schedule 'H' b. Schedule 'V' c. Schedule 'X' d. Schedule 'Q'
8. In HPLC, which pump gives a mobile phase flow rate dependent on column permeability?
a. Constant pressure pumps b. Constant displacement pumps
c. Reciprocating pumps d. Pneumatic pumps
9. Which of the following organism is the Source for amphotericin?
a. Streptomyces immodosus b. Streptomyces nodosus
c. Streptomyces griseus d. Streptomyces aureofaciens
10. Which of the following drug produces gastric irritation after micronization?
a. Phenobarbital b. Tetracycline
c. Erythromycin d. Nitrofurantoin
11. Adult dose of a drug is 150 mg/kg and the drug is available as tablets of 2 mg
strength. Calculate the dosed required for a boy of age 14 yrs and weight of 35 kg?
a. 74.9 mg b. 78 mg c. 82 mg d. 80 mg
12. Which of the following method is used to measure respiratory efficiency of cells in
cell culture?
a. Fluroscein Diacetate method b. Reduction of tetrazolium salts
c. Evan's blue method d. Calcofluor white method
13. Which of the following Dopaminergic agonist used in the treatment of
Parkinsonism?
a. Levodopa b. Carbidopa c. Mirtazapine d. Ropinirole
14. What is the principle involved in the VDRL test?
a. Agglutination b. Precipitation c. Flocculation d. Opsonisation
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MODEL PRE-GPAT QUESTION PAPER WITH

ANSWERS KEY

  1. Which of the following anti-arrhythmic drug is having Iodine? a. Disopyramide b. Flecainide c. Amiodarone d. Quinidine 2. The quality of Coca leaves is mainly dependent on which of the following constituents? a. Cocaine b. Truxilline c. Ecgonine d. Cinnamyl cocaine 3. CH 3 O-^ Na+^ + CH 3 Cl - CH 3 - O - CH 3 + NaCl The above reaction is an example for which of the following? a. Williamson reaction b. Clemmenson reaction c. Wuotz's reaction d. Reformatsky reaction 4. Which of the following gelatine concentration is used to determine the viscosity of gelatine used for the preparation of soft gelatine capsules? a. 6 2/3^ % b. 7 2/3% c. 5 2/3^ % d. 6 3/4% 5. Which of the following group is detected by using Herzig Meyer method? a. Alkyl group b. Hydroxy group c. Alkoxy group d. N-alkyl group 6. Which of the following drug blocks the sodium channel and dissociates slowly? a. Quinidine b. Lignocaine c. Flecainide d. Procainamide 7. According to Drugs and Cosmetics act, List of substances that should be sold by retail only on prescription of registered medical practitioner is given in which of the following Schedule? a. Schedule 'H' b. Schedule 'V' c. Schedule 'X' d. Schedule 'Q'
  2. In HPLC, which pump gives a mobile phase flow rate dependent on column permeability? a. Constant pressure pumps b. Constant displacement pumps c. Reciprocating pumps d. Pneumatic pumps 9. Which of the following organism is the Source for amphotericin? a. Streptomyces immodosus b. Streptomyces nodosus c. Streptomyces griseus d. Streptomyces aureofaciens 10. Which of the following drug produces gastric irritation after micronization? a. Phenobarbital b. Tetracycline c. Erythromycin d. Nitrofurantoin 11. Adult dose of a drug is 150 mg/kg and the drug is available as tablets of 2 mg strength. Calculate the dosed required for a boy of age 14 yrs and weight of 35 kg? a. 74.9 mg b. 78 mg c. 82 mg d. 80 mg 12. Which of the following method is used to measure respiratory efficiency of cells in cell culture? a. Fluroscein Diacetate method b. Reduction of tetrazolium salts c. Evan's blue method d. Calcofluor white method 13. Which of the following Dopaminergic agonist used in the treatment of Parkinsonism? a. Levodopa b. Carbidopa c. Mirtazapine d. Ropinirole 14. What is the principle involved in the VDRL test? a. Agglutination b. Precipitation c. Flocculation d. Opsonisation

15. Prazocine is a derivative of which of the following? a. Quinazoline b. Phthalazine c. Quinoline d. Isoquinoline 16. Bladder toxicity is the side effect of which of the following drug? a. Vincristine b. Cyclophosphamide c. 5-Flouro Uracil d. Doxorubicin 17. Which of the following is a prototype of Sedative? a. Chloral hydrate b. Chloral c. Chloroquine d. Chlorpheniramie 18. If the half life for decomposition of a drug is 12 hrs, how long will it take for 125 mg of the drug to decompose by 30 %? Assume that the drug follows first order kinetics at constant temperature. a. 6.1 hr b. 8.2 hr c. 7.9 hr d. 5.5 hr 19. Which of the following is used as Cuticle Remover? a. Nitrocellulose b. Mineral oil c. Trisodium phosphate d. Acetoglyceride 20. Which of the following amino acid is present in Captopril? a. Glycine b. Cysteine c. Proline d. Para Amino benzoic acid 21. Which of the following is the biosynthetic origin for an amino alkaloid Ephedrine? a. Phenyl alanine and Ornithine b. Phenyl alanine and Pyruvic acid c. Histidine and Threonine d. Tyrosine and Dihydroxy phenyl alanine 23. Which of the following is the responsible for prolonged QT interval? a. Hypokalemia b. Tricyclic anti-depressants c. Hypercalcemia d. Left ventricular hypertrophy 24. Metastable peaks are always present at a. Even mass numbers b. Integral mass numbers c. Odd mass d.Non-integral mass 25. Which of the following antacid produces constipation? a. Sodium citrate b. Magnesium hydroxide c. Magnesium trisilicate d. Aluminium hydroxide gel

  1. Calculate the amount of sodium chloride required to make 1.5 % solution of pilocarpine HCl isotonic with tear secretion? (Freezing point depression of 1 % pilocarpine HCl is - 12^0 C and that of sodium chloride is - 0.576^0 C). a. 0.564 % w/v b. 0.712 % w/v c. 0.224 % w/v d. 0.693 % w/v 27. Lecithin is incorporated in shampoos as a. Conditioning agent b.Clarifying agent c. Opacifying agent d. pH adjusting agent 28. What is the % of ionisation of a drug with pKa 5 at pH 8? a. 99.9 % b. 99.99 % c. 90 % d. 99 % 29. Which of the following antihypertensive drug used in the treatment of alopecia? a. Minoxidil b. Diazoxide c. Reserpine d. Hydralazine 30. What is the use of infusion of Tulsi leaves? a. Insecticidal b. Spasmolytic c. Stomachic d. Stimulant 31. The conductivity of the solution of an electrolyte is a. Independent of Temperature b. Dependent of Temperature c. Dependent of Both Temperature and Pressure d. Dependent of Pressure applied

49. Which of the following member is an ex-officio member of the State Pharmacy council? a. Chief pharmacist of Government hospital b. Chief Administrative medical officer of the State c. Registered pharmacist d. Assistant drug controller 50. Which of the following antidote antagonize the peripheral action of Organophosphorus compounds? a. Atropine b. Aspirin c. Charcoal d. Caffeine 51. Which of the following Quinoline derivatives is used in the treatment of bacillary dysentery? a. Nalidixic acid b. Naphthaquinone c. Quinoline d. Anthraquinone 52. Polarogram of a solution containing an electro-reducible substance is obtained by plotting a. Potential Vs Volume b. Current Vs Volume c. Resistance Vs Time d. Current Vs Potential 53. Which of the following is used for the assessment of growth in suspension culture? a. Packed cell volume b. Fluroscein Diacetate method c. Reduction of tetrazolium salts d. Calcofluor white method 54. Which of the following is the synthetic membrane? a. Cetyl alcohol b. Cholesterol c. Myricyl alcohol d. n - Octanol 55. Calculate bulk density of paracetamol granules having a true density of 1.8 and % porosity of 60? a. 1.098 b. 1.08 c. 0.72 d. 1.

  1. How many number of ester bonds present in phospholipids? a. 4 b. 3 c. 2 d. 5
  2. Which of the following is the synthetic derivative of Opium alkaloid? a. Papaverine b. Heroin c. Pethidine d. Thebaine
  3. Statto - Oto method is used for the isolation of which of the following? a. Carbohydrates b. Glycosides c. Volatile oils d. Lipids
  4. Which of the following disease susceptibility can be determined by Shick test? a. Measles b. Diphtheria c. Polio d. Typhoid
  5. Monoamine Oxidase is located in which of the following? a. Mitochondria b. RER c. Plasma d. Intestine
  6. Which of the following is the IUPAC name for Progesterone? a. Pregn-2-ene-3, 20-dione b. Pregn-4, 6-dien-3, 20-dione c. Pregn-2, 6-diene-3, 20-dione d. Pregn-4-ene-3, 20-dione
  7. Which of the following is an example for natural emulsifying agent of animal origin? a. Agar b. Acacia c. Chondrus d. Gelatine
  8. Which of the following alkaloidal drug is having pseudo parenchyma? a. Nuxvomica b. Cardamom c. Digitalis d. Ergot
  9. Basophiles are having receptors for which of the following antibodies? a. Ig G b. Ig A c. Ig M d. Ig E
  10. Which of the following is an example for Thermal Conductivity Detector?

a. Flame Thermocouple Detector b. Flame Thermionic Detector c. Katharometer d. Flame Ionization Detector

  1. Which of the following metabolites usually undergo enterohepatic circulation? a. Glucuronate conjugates b. Phenols c. Acetyl conjugate d. Methyl conjugate
  2. Which of the following semipermeable membrane used in haemodialysis? a. Cellophane b. Cellulose acetate c. Polyethene d. Polyvinyl acetate
  3. Which part of the umbelliferous fruits is having high content of volatile oils? a. Mesocarp b. Pericarp c. Schizocarp d. Epicarp
  4. Which of the following Glutamate antagonist used in Alzheimer's disease? a. Felbamate b. Sulthiame c. Memantine d. Phenytoin
  5. Mass spectra is usually obtained by a. Electron impact b. Electron captures c. Atomic fission d. Accelerated potentials
  6. Which of the following is the active metabolite of Phenacitin? a. p - Amino phenol b. p - Ethoxy aniline c. p - Hydroxy phenyl acetanilide d. Acetanilide
  7. Which of the following toxins are produced by E.coli? a. Enterotoxin b. Endotoxins c. Verocytotoxins d. Haemolysins
  8. Which of the following are identified by using Borax test? a. Saponins b. Barbaloins c. Digitoxin d. Gelatine
  9. Iron content of gelatine used for the preparation of soft capsule should not be more than a. 15 ppm b. 20 ppm c. 25 ppm d. 30 ppm
  10. Which of the following antihypertensive drugs acts as MAO inhibitor? a. Tranylcypromone b. Reserpine c. Prazocine d. Pargyline
  11. Pantothenic acid is a constituent of the coenzyme involved in a. Decarboxylation b. Dehydrogenation c. Acetylation d. Oxidation
  12. What is the metabolic advantage of Procainamide compared to Procaine? a. It does not undergo hydrolysis by amidase b. It does not undergo hydrolysis by esterase c. It does not undergo N - Dealkylation d. None of the above
  13. Which of the following technique single step purification of sample is achieved? a. Ion exchange chromatography b. Affinity chromatography c. Gel filtration d. All the above
  14. Which of the following is readily used for the filling of pelletized or granular material into Capsules? a. Rotosort b. Rotofil c. Accofil d. Rotoweigh
  15. Where biological and microbiological tests are conducted? a. Bombay b. Calcutta c. Madras d. Kasauli
  16. Which among the following is Gyrase inhibitor? a. Cephalexin b. Vancomycin c. Norfloxacin d. Linezolid
  17. Calculate the amount of 95 % alcohol required to prepare 400 ml of 45 % alcohol? a. 190 ml b. 844 ml c. 240 ml d. 120 ml

a. Somatostatin b. Dopamine c. Glucocorticoids d. None of the above

  1. Which of the following is obtained by fusion of Morphine with potassium hydroxide? a. Veratric acid b. Valerianic acid c. Proto Catechuic acid d. Homoveratrole
  2. A solution of drug was prepared freshly at a concentration of 300 mg/ml. After 25 days of storage at 25 OC, the drug concentration in the solution was found to be 120 mg/ml. The drug assumed to undergo zero-order kinetics. Calculate the reaction rate constant? a. 7.2 mg/ml/day b. 62.5 mg/ml/day c. 0.72 mg/ml/day d. 6.25 mg/ml/day Questions 22,46&100 are omitted due to technical problem..!!!!!! KEY: 1 c 2 c 3 a 4 a 5 d 6 c 7 a 8 a 9 b 10 d 11 a 12 b 13 d 14 b 15 a 16 b 17 b 18 a 19 c 20 c 21 b 23 a 24 d 25 d 26 a 27 a 28 a 29 a 30 c 31 b 32 a 33 c 34 a 35 d 36 a 37 b 38 b 39 d 40 c 41 a 42 d 43 a 44 c 45 d 47 a 48 a 49 b 50 a 51 a 52 a 53 a 54 d 55 c 56 a 57 c 58 b 59 b 60 a 61 d^ 62 d^ 63 d^ 64 d^ 65 c^ 66 a^ 67 a^ 68 a^ 69 c^ 70 a 71 c 72 b 73 b 74 a 75 a 76 c 77 b 78 c 79 b 80 d 81 c 82 a 83 a 84 d 85 d 86 a 87 c 88 d 89 a 90 b 91 b 92 d 93 b 94 d 95 b 96 a 97 b 98 c 99 a