Homeostasis, ANS, Endocrine System, Blood, Summaries of Anatomy

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Anatomy Midterm Exam Review Guide
1. Homeostasis
โ€ข Definition: Maintenance of a stable internal environment despite external
changes (temperature, pH, glucose, etc.).
โ€ข Dynamic equilibrium โ€“ conditions fluctuate around a set point (like a
thermostat).
โ€ข Law of Mass Balance โ€“ input must equal output (e.g., water intake = water
loss).
โ€ข Regulated by the Nervous (fast, electrical) and Endocrine (slow, hormonal)
systems.
Homeostatic Control Mechanism
Receptor โ†’ Control Center โ†’ Effector
โ€ข Receptor detects change (stimulus) โ†’ sends info via afferent pathway to
control center.
โ€ข Control Center (usually brain/hypothalamus) compares input to set point โ†’
sends output via efferent pathway.
โ€ข Effector produces a response to restore balance.
Mnemonic: R-C-E โ†’ Receive, Control, Execute.
Feedback Types
โ€ข Negative Feedback: response reverses the change โ†’ stabilizing (e.g.,
temperature, glucose).
โ€ข Positive Feedback: response amplifies the change โ†’ self-reinforcing (e.g.,
labor, blood clotting).
Positive feedback is rare and requires termination by negative feedback.โš ๏ธ๎˜‚
Examples:
โ€“ Thermoregulation: โ†“ temp โ†’ shivering (muscles) โ†’ โ†‘ heat โ†’ restored
balance.
โ€“ Childbirth: โ†‘ stretch โ†’ โ†‘ oxytocin โ†’ โ†‘ contractions โ†’ baby born โ†’ cycle
stops.
2. Autonomic Nervous System (ANS)
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Anatomy Midterm Exam Review Guide

1. Homeostasis

  • Definition: Maintenance of a stable internal environment despite external changes (temperature, pH, glucose, etc.).
  • Dynamic equilibrium โ€“ conditions fluctuate around a set point (like a thermostat).
  • Law of Mass Balance โ€“ input must equal output (e.g., water intake = water loss).
  • Regulated by the Nervous (fast, electrical) and Endocrine (slow, hormonal) systems. Homeostatic Control Mechanism Receptor โ†’ Control Center โ†’ Effector
  • Receptor detects change (stimulus) โ†’ sends info via afferent pathway to control center.
  • Control Center (usually brain/hypothalamus) compares input to set point โ†’ sends output via efferent pathway.
  • Effector produces a response to restore balance. Mnemonic: R-C-E โ†’ Receive, Control, Execute. Feedback Types
  • Negative Feedback: response reverses the change โ†’ stabilizing (e.g., temperature, glucose).
  • Positive Feedback: response amplifies the change โ†’ self-reinforcing (e.g., labor, blood clotting). โš ๏ธ Positive feedback is rare and requires termination by negative feedback. Examples:
  • Thermoregulation: โ†“ temp โ†’ shivering (muscles) โ†’ โ†‘ heat โ†’ restored balance.
  • Childbirth: โ†‘ stretch โ†’ โ†‘ oxytocin โ†’ โ†‘ contractions โ†’ baby born โ†’ cycle stops.

2. Autonomic Nervous System (ANS)

  • Part of the PNS controlling involuntary functions (smooth & cardiac muscle, glands).
  • Maintains homeostasis by balancing sympathetic and parasympathetic activity. Somatic vs. Autonomic Feature Somatic NS Autonomic NS Control Voluntary Involuntary Effectors Skeletal muscles Smooth/cardiac muscles, glands Neurons Single motor neuron Two-neuron chain (pre & postganglionic) Neurotransmitters ACh (excitatory) ACh & NE (excite/inhibit) Effect Always excitatory Excitatory or inhibitory Sympathetic vs. Parasympathetic
  • Sympathetic: 'Fight or Flight' โ†’ โ†‘ HR, dilate pupils, โ†“ digestion, release glucose.
  • Parasympathetic: 'Rest and Digest' โ†’ โ†“ HR, constrict pupils, โ†‘ digestion.
  • Dual innervation: both divisions act on same organs with opposite effects. Key Differences
  • Sympathetic (thoracolumbar): short preganglionic, long postganglionic, NE release.
  • Parasympathetic (craniosacral): long preganglionic, short postganglionic, ACh release. Mnemonic: Sympathetic = Stress; Parasympathetic = Peace. CNS Control of ANS
  • Hypothalamus: main integration center ('the boss').
  • Brainstem: controls reflexes (heart rate, breathing, pupil size).
  • Spinal cord: handles defecation, urination, sexual reflexes.
  • Limbic system & cortex can influence ANS (emotional control).

Functions: Transport, Regulation, Protection. Plasma

  • 90% water, 8% plasma proteins, 2% solutes. Major proteins:
  • Albumin (osmotic balance, carrier protein)
  • Globulins (antibodies, transport)
  • Fibrinogen (clotting) Formed Elements
  • RBCs (Erythrocytes): carry Oโ‚‚ via hemoglobin.
  • WBCs (Leukocytes): immune defense.
  • Platelets: clot formation. Erythrocytes (RBCs)
  • Biconcave, no nucleus/mitochondria, packed with Hb.
  • Hemoglobin = 4 globin chains + 4 heme groups; each heme binds 1 Oโ‚‚.
  • Life span: 120 days โ†’ destroyed by spleen/liver macrophages.
  • Regulated by EPO (erythropoietin) from kidneys โ€“ triggered by low Oโ‚‚ (negative feedback). Nutrients: Iron (heme synthesis), B12 & folic acid (DNA synthesis). Blood Disorders
  • Anemia โ€“ low RBCs/Hb โ†’ fatigue, pallor, low Oโ‚‚ capacity.
  • Sickle-cell โ€“ defective Hb โ†’ rigid cells, block vessels.
  • Polycythemia โ€“ excess RBCs โ†’ โ†‘ blood viscosity.
  • Leukemia โ€“ WBC cancer.
  • Thrombocytopenia โ€“ low platelets โ†’ bleeding risk. Clinical Mnemonics:
  • 'Too few = fatigue; Too many = thick blood.'
  • 'EPO: Erythrocyte Production Order (Kidneys โ†’ Marrow).'