Study with the several resources on Docsity
Earn points by helping other students or get them with a premium plan
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
If you are clinical pharmacy student you have to Study hard
Typology: Lecture notes
1 / 52
This page cannot be seen from the preview
Don't miss anything!
11/30/2024 For 3rd Year B.pharm Student 1
Course Title: Immunological and Biological Products
rd
By :- MENBERE DEBELE (BSc.in C/Nurse & B.Pharm)
11/30/2024 For 3rd Year B.pharm Student 2
Introduction to Biotechnology and Pharmaceutical Biotechnology Introduction to genetic engineering/rDNA technology Immunological products and biological products
11/30/2024 For 3rd Year B.pharm Student 4
Biotechnology means any scientific application that uses biological systems, living organisms or derivatives thereof, to produce or alter products or processes for particular use. Hungarian engineer Karl Ereky first coined the term ‘biotechnology’ in 1919, meaning the production of products from raw materials with the aid of living organisms.
11/30/2024 For 3rd Year B.pharm Student 5
Pharmaceutical biotechnology is a branch of biomedical sciences that uses novel technologies for production, formulation, and synthesis of biological substances from the living organisms
- Which act as drug molecules for the treatment and/or prevention of various diseases and/or syndromes.
11/30/2024 For 3rd Year B.pharm Student 7
The utilization of living organisms , systems or processes constitutes biotechnology’ to describe a process for large scale production of pigs. Biotechnology can also be defined as application of technology Using the living organisms to obtain useful products.
11/30/2024 For 3rd Year B.pharm Student 8
Biotechnology is integrated use of biochemistry, microbiology and engineering sciences in order to achieve technological applications of microbes, cultured cells and parts there of. Pharmaceutical products produced by biotechnology Biological product because of its structural and mechanistic similarity to naturally occurring substances in the human body
11/30/2024 For 3rd Year B.pharm Student 10 Biotechnology and its various stages of development Generally, biotechnology utilizes living material or biological products to generate new products for use in various medical, agricultural, pharmaceutical and environmental applications. The ultimate goal of biotechnology is to benefit humanity by, for example, the production of resistant crops, vegetables, recombinant proteins, higher milk-producing animals , etc.
11/30/2024 For 3rd Year B.pharm Student 11
Different developmental stages have taken place in biotechnology to meet the various needs of humans at the time. Its development was principally based on observations, and the application of these observations to practical scenarios. Owing to the evolution of new technologies and a better understanding of various principles of life science, the complexity of biotechnology has increased.
11/30/2024 For 3rd Year B.pharm Student 13 Converging on DNA 1902: Human genetics is born; 1905: X and Y chromosomes related to gender, Mutation theory Basis of modern genetics; 1957: Central dogma of DNA—how DNA makes a protein
11/30/2024 For 3rd Year B.pharm Student 14 1900–1953: Genetics. 1953–1976: DNA research, science explodes. Modern biotechnology (1977): Manipulates genetic information in organisms; genetic engineering ; various technologies enable us to improve crop yield and food quality in agriculture and to produce a broader array of products in industries.
11/30/2024 For 3rd Year B.pharm Student 16
o 1960s: Several key discoveries in biology underpin biotechnology, namely, universality of genetic code 64 specific nucleic acid triplet codes are responsible for interpretation of genes into proteins, and genetic material is transferable among different organisms -central dogma
11/30/2024 For 3rd Year B.pharm Student 17
In early 1970s there were the development of the two core technologies of biotechnology , i.e. r-DNA and Mabs, In 1982, marketing recombinant human insulin , the first commercial pharmaceutical product derived from biotechnology
11/30/2024 For 3rd Year B.pharm Student 19
1982 Production of genetically engineered recombinant human insulin protein in bacteria 1984 The first cloning and sequencing of the entire human immunodeficiency virus (HIV) genome. Alec Jeffreys introduces technique for DNA fingerprinting to identify individuals. 1985 The discovery of Polymerase Chain Reaction by Mullis 1986 First recombinant vaccine (Hepatitis B) 1988 the first patent for a genetically altered animal, a mouse that is highly susceptible to breast cancer 1989 The gene identification of Cystic fibrosis on chromosome number 7 with linkage analysis 1990 The first successful gene therapy takes place, on a four-year-old girl with an immune-system disorder called ADA deficiency, The human genome project is formally launched
11/30/2024 For 3rd Year B.pharm Student 20
year Historic event 1990 The first BRCA1 gene is discovered 1994 The first BRCA2 gene is discovered. 1997 Cloning of Dolly 1997 The FDA approves Rituxan, the first antibody-based therapy for cancer 1998 The first complete animal genome (C.elegans) is sequenced 1998 The production of embryonic stem cell 1998 Discovery of RNA interference
