Introduction to Cell Physiology, Study notes of Physiology

Contains an introduction to cell physiology, components of the cell, parts of the cell, and active and passive transport.

Typology: Study notes

2020/2021

Available from 10/17/2021

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Topic: Cell Physiology
Homeostasis- maintenance of the and consistency of the internal environment
-failure to maintain disease/death
2 Major Fluid Compartments
ICF Intracellular Fluid
- Bigger
- 2/3 of the total body fluid
- 25L (40%) body weight
ECF Extracellular Fluid
- Smaller
- 1/3 of the total body fluid
- 20% total body weight
- Components:
Interstitial Fluid 4/5
- ECF that fills the narrow spaces between cells
Plasma and lymph- 1/5
- Plasma ECF within blood vessels
- Lymph- ECF within lymphatic vessels
Cell basic structural or functional unit of the body
Chemical Components:
1.) Water 75-85%
a. Free water- for metabolic process
- Cellular growth
- Stored energy
b. Bound water- attached to proteins
Functions: Vesicle for suspension for cellular particles (cytoplasm)
Transport for substances to and from the cell.
2.) Proteins 10-20%
a. Fibrous / structural elongated
b. Globular / enzymatic spheroidal
c. Nucleoproteins with RNA and DNA (with hereditary component)
3.) Lipids/ Fats -2-3%
Functions: acts as food or energy reserves
-important role in the cell membrane (lipid bilayer) (phospholipids, cholesterol)
4.) Carbohydrates 2-3%
Functions: source of chemical energy for generating ATP needed to drive metabolic reactions
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Topic: Cell Physiology Homeostasis- maintenance of the and consistency of the internal environment

  • failure to maintain disease/death 2 Major Fluid Compartments
  • ICF – Intracellular Fluid
  • Bigger
  • 2/3 of the total body fluid
  • 25L (40%) body weight
  • ECF – Extracellular Fluid
  • Smaller
  • 1/3 of the total body fluid
  • 20% total body weight
  • Components: ▪ Interstitial Fluid – 4/
  • ECF that fills the narrow spaces between cells ▪ Plasma and lymph- 1/
  • Plasma – ECF within blood vessels
  • Lymph- ECF within lymphatic vessels Cell – basic structural or functional unit of the body Chemical Components: 1.) Water – 75 - 85% a. Free water- for metabolic process
  • Cellular growth
  • Stored energy b. Bound water- attached to proteins Functions: Vesicle for suspension for cellular particles (cytoplasm) Transport for substances to and from the cell. 2.) Proteins – 10 - 20% a. Fibrous / structural – elongated b. Globular / enzymatic – spheroidal c. Nucleoproteins – with RNA and DNA (with hereditary component) 3.) Lipids/ Fats - 2 - 3% Functions: acts as food or energy reserves
  • important role in the cell membrane (lipid bilayer) (phospholipids, cholesterol) 4.) Carbohydrates – 2 - 3% Functions: source of chemical energy for generating ATP needed to drive metabolic reactions

5.) Salt / ions/ electrolytes – 1% Function: Important for metabolic activities a.) Cations – (+) charged b.) Anions – (-) charged *** PISO – Potassium In Sodium Out K - major cation intracellularly Na - major cation extracellayly Cl- extracellular anion Parts of the Cell 1.) Nucleus – most important part

  • with nucleolus
  • nuclear membrance – with pores for transport of molecules
  • control center of the cell Functions: controls or regulates metabolic activities and cellular growth or reproduction 2.) Cytoplasm – fluid between cell membrane and nucleus ; with many cellular substances a. Ribosomes- particulate substance
  • “ribonucleoproteins”
  • Composed of 65% RNA & 35% proteins
  • Function: protein synthesis
  • 2 types: Free ribosomes – able to move throughout the cell Bound ribosomes- attached to Endoplasmic reticulum b. Endoplasmic Reticulum- collection of tubules and vesicles ; connects nucleus, golgi apparatus and cell membrane i. Function: provides intercommunication between the interior and exterior of the cell ii. 2 types
    1. Rough / Granular – with ribosomes ; storage and synthesis of proteins
    2. Smooth/ Agranular – steroids, glycogen, lipids; storage and synthesis of glycogen c. Mitochondria – powerhouse of the cell
  • rod / sausage shaped
  • double walled • 1st wall • 2nd wall – inward / cristae
  • generates ATP (adenosine triphosphate) – energy currency of the cell ; for muscle contraction, metabolic activities, transport mechanisms
  • SELF-REPLICATING = does not need command from nucleus ; has RNA
  • its number reflects the metabolic activity of the cell
  • higher = faster metabolic activity d. Lysosomes – digestive system of cells
  • lysis / autolysis of dead cells

PASSIVE

- (-) ATP

  • (-) carrier mediated except: Facilitated diffusion (with carrier protein, faster that ordinary diffusion)
  • downhill = greater to lesser concentration gradient
  • along concentration gradient
  • along gravity
  • Examples: diffusion, osmosis, bulk flow, filtration
  • Osmosis = > to < solvent = < to > solute = < to > osmotic pressure
  • Osmotic pressure – pressure that attracts water
    • number of solutes osmotic pressure (directly proportional) *Normal cell= isotonic
  • When suspended in isotonic = isotonic ( nothing changes) Isotonic to hypotonic = cell volume increases = cell swelling Isotonic to hypertonic = cell volume decreases = cell shrinkage *Bulk flow= movement of large number of ions towards one direction = always parallel *Filtration = transport of molecules through a membrane when there is difference in pressure = with higher pressure greater molecules will move across the membrane