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What infectious agent is the cause of "snuffles" in rabbits? a) Mycoplasma pulmonis b) Sendai virus c) Bordetella bronchiseptica d) Pasteurella multocida - Answer D Which of the following is not one of the major clinical signs of inflammation? a) Heat b) Analgesia c) Redness d) Pain - Answer B The destruction of all organisms on an object is referred to as: a) Sterilization b) Disinfection c) Pasteurization d) Sanitization - Answer A Which of the following is not a type of animal facility design? a) Conventional b) Barrier c) VAF/SPF d) Clean/Dirty - Answer C Which regulatory agency performs annual unannounced site inspections and enforces the Animal Welfare Act? a) AAALAC, Int. b) FDA c) PHS d) USDA - Answer D ___________ pathology is the study of the structure of diseased tissues. a) Topical b) Clinical c) Microscopic d) Anatomical - Answer D Which types of animals are reared in open (non-filtered) cages and have an unknown microbial status? a) SPF b) Germfree c) Gnotobiotic d) Conventional - Answer D
Which of the following warm-blooded vertebrates is not regulated by the Animal Welfare Act? a) Horses used for antibody production b) Sheep used in open heart surgery research c) Pigeons used for behavioral testing d) Wild rats used for viral infection - Answer C ___________ is the science of poisons and the harmful or noxious effects these substances have on living organisms. a) Histology b) Botany c) Pathology d) Toxicology - Answer D If an animal dies spontaneously, changes in the tissues begin to occur as the body decomposes. This process is called autolysis. What is the best way to preserve tissues for a diagnostic necropsy? a) Place the dead animal in a freezer b) Place the animal in an autoclave c) Place the animal in a refrigerator d) Leave the animal in the exact location where it died - Answer C What is the term used to describe the study of birth defects? a) Teratology b) Gynecology c) Obstetrics d) Mutitology - Answer A The written document that an investigator must complete, and submit to their Institutional Animal Care and Use Committee, if they plan to use animals in research is called the ___________________. a) Animal use protocol b) Animal use grant c) Research use protocol d) Research use grant - Answer A How long can bacteria survive when kept in the transport media of a sterile swab? a) 24 hrs. b) 48 hrs. c) 72 hrs. d) 96 hrs. - Answer A The word, "hypothyroidism", has the prefix _____, the suffix ________, and the root __________. a) ism; hypo; thyroid b) hypo; ism; thyroid c) thyroid; hypo; ism d) hypo; thyroid; ism - Answer B
b) Prolapse c) Evisceration d) Dehiscence - Answer D Neonatal (newborn) animals require _________ exposure to carbon dioxide to cause death compared to adult animals. a) No b) Longer c) Shorter d) Same - Answer B Which of the following is the correct formula for the conversion of Fahrenheit degrees to Celsius degrees? a) F=5/9 (C-32) b) C=5/9 (F-32) c) F=9/5 (C-32) d) C=9/5 (F-32) - Answer B If the cagewash temperature is 210 F. What is this temperature on the Celsius scale? a) 25 C b) 54 C c) 82 C d) 99 C - Answer D _____________ is the process by which the number of bacteria and other organisms living on inanimate objects is reduced enough to prevent disease. a) Disinfection b) Sanitization c) Sterilization d) Pasteurization - Answer B Which of the following are considered types of acute toxicity tests? a) FETAX & Lymphocytes assay b) LD50 & Draize test c) LAL assay & LD d) In vitro micronucleus & Guinea pig dermal test - Answer B An animal room, which uses special cages and procedures such as autoclaved food, bedding, and caging, is considered what type of animal room? a) Conventional b) Gnotobiotic c) Barrier d) Specific pathogen-free (SPF) - Answer C A _______________ toxicity test varies from 13-26 weeks in duration and usually involves rodents or dogs. The animals are dosed on a daily basis in a similar manner that may be administered to humans. a) Subacute
b) Subchronic c) Acute d) Chronic - Answer B What does the acronymn PCR stand for? a) Polymerase chain reaction b) Polychromatic reticulocytes c) Packed clotted red blood cells d) Polyallelic canine retinopathy - Answer A The anatomical term "dorsal" means "towards the __________________." a) Abdomen b) Back c) Head d) Rear - Answer B What color is air in the lungs of a normal animal on a radiograph (x-ray)? a) White b) Gray c) Black d) Blue - Answer C What does the term specific pathogen-free indicate? a) Animals do not have any diseases b) Animals are born without any bacteria or viruses c) Animals do not have certain diseases which normally infects the species d) Animals do not have any pathogens of any kind - Answer C A barrier animal facility has special provisions for traffic flow. What direction should airflow be inside the room to prevent transmission of airborne viruses and bacteria? a) Positive pressure b) Negative pressure c) Balanced pressure between room and hallway d) Either positive or negative because there are no airborne diseases - Answer A Which organization represents the interests of the public and the scientific community in the area of legislation and regulations on the use of laboratory animals? a) IACUC b) PETA c) AMP d) NABR - Answer D The function of capillaries are to _____________________. a) Filter the blood b) Recover lost blood c) Deliver oxygen to the blood d) Deliver oxygen to the tissues - Answer D
d) 4 years - Answer C ________________ Rates are the expenses directly charged to a PI to care for one animal for one day in a research facility? a) Average daily census b) Per diem c) Cost centers d) Centralized management - Answer B How often is the IACUC required to review an institutions animal care program and inspect the animal facilities? a) Every 3 months b) Every 6 months c) Every 12 months d) Every 24 months - Answer B Chronic toxicology testing is conducted in mice and rats. This type of toxicology testing is used to assess toxicity and ________ of drug candidates. a) Oncogenicity b) Hematology c) Pharmacology d) Pathogenicity - Answer A The correct order of occurrence (from left to right) of reproductive events seen in a breeding program is _________________________. a) Weaning; ovulation; gestation; lactation; parturition b) Lactation; parturition; ovulation; gestation; weaning c) Ovulation; gestation; parturition; lactation; weaning d) Parturition; weaning; ovulation; gestation; lactation - Answer C Which type of facility is designed to prevent the possibility of cross contamination of clean equipment with dirty equipment? a) Clean/Clean b) Clean/Dirty c) Conventional d) VAF/SPF - Answer B How often does AAALAC, Int. perform site inspections and program evaluations of an accredited institution? a) Once every two years b) Once every three years c) Once every four years d) Once every five years - Answer B The term ________refers to transmission of infectious agents from animals to humans or from humans to animals. a) Contagious b) Infectious c) Zoonotic
d) Panepidemic - Answer C What term is used to indicate that a pregnant animal during parturition is unable to deliver offspring naturally because the uterus is fatigued or not functioning properly? a) Uterine inertia b) Dystocia c) Pregnancy toxemia d) Uterine palsy - Answer A Which of the following routes of administration is the slowest in terms of rate of absorption? a) Intraperitoneal b) Intradermal c) Subcutaneous d) Intravenous - Answer B In terms of rate of absorption, which of the following is in the correct order from fastest to slowest? a) IV>SQ>IM>IP b) IP>IV>IM>ID c) IP>IM>SQ>ID d) IV>IM>ID>SQ - Answer C The quadriceps muscles are a large muscle mass that is ideal for intramuscular injections. This group of muscles is located over the _________ portion of the femur. a) Anterior b) Posterior c) Ventral d) Dorsal - Answer A Which location should an intraperitoneal injection be given to avoid all of the major abdominal organs? a) Upper right quadrant of the abdomen b) Upper left quadrant of the abdomen c) Lower right quadrant of the abdomen d) Lower left quadrant of the abdomen - Answer C During an intraperitoneal injection in a guinea pig, you notice yellow colored fluid in the hub of your needle. What organ has your needle most likely penetrated? a) Kidney b) Bladder c) Cecum d) Gallbladder - Answer B Retro-orbital injection and cardiac puncture should be performed with the animal under ___________________. a) Sedation
The unique anatomy of their stomach prevents these animals from vomiting? a) Horses and cows b) Rats and mice c) Horses and rats d) Frogs and snakes - Answer C What does BSL stand for? a) Biological safety laboratory b) Biologically safe levels c) Biosafety laboratory d) Biosafety levels - Answer D The "true stomach" in ruminant animals is known as the __________. a) Rumen b) Reticulum c) Omasum d) Abomasum - Answer D Which two species do not have a gallbladder and therefore have a continuous movement of bile into the small intestine? a) Pig and Sheep b) Gerbil and Chicken c) Horse and rat d) Mouse and hamster - Answer C The type of caging material that has high impact strength, is transparent and can withstand high temperatures is ___________________. a) Polypropylene b) Polystyrene c) Polycarbonate d) Polyethylene - Answer C Which of the following is not considered a common method of sterilization in an animal facility? a) Wet heat b) Dry heat c) Chemicals d) Contact - Answer D Strains are considered inbred after being mated for _____ generations. a) 10 b) 20 c) 40 d) 100 - Answer B Small rodents are commonly anesthetized with either the open drop method or open anesthetic chambers. If either of these methods is used, what device should be used to prevent exposure of anesthetic gases to humans? a) Apnea monitor
b) Fume hood c) CO monitor d) CO2 monitor - Answer B While monitoring a rat during routine anesthesia, you decide to check the depth of anesthesia. When you pinch the rat's foot, the animal withdraws its entire limb. What does this reaction indicate? a) The animal is in an adequate plane of anesthesia b) The animal is not in an adequate plane of anesthesia c) The animal is too deep and death is eminent d) The animal is dead and this is an autonomic reflex - Answer B Which term can also be used to describe a "germfree" animal? a) Axenic b) Gnotobiotic c) VAF d) Bacteria free - Answer A The _____________ of an animal is its physical characteristics or appearance. a) Phenotype b) Genotype c) Synotype d) Histotype - Answer A Which of the following homozygous conditions prevents the gene expression of any coat color, resulting in an albino mouse? a) cc b) CC c) AA d) aa - Answer A If the genes for coat color in a guinea pig are identical the animal is said to be: a) Heterozygous for coat color b) Homozygous for coat color c) Dominant for coat color d) Recessive for coat color - Answer B The mating of two heterozygous black mice (B/b) results in which of the following percent of offspring? a) 50% black & 50% brown phenotype b) 75% black & 25% brown phenotype c) 100% black phenotype d) 75% brown & 25% black phenotype - Answer B Which of the following symbols is used to indicate an inbred strain? a) : b) / c) ;
indicator for testing adequate sterilization in an autoclave? a) Bacillus piliformis b) Staphylococcus aureus c) Borrelia burgdorferi d) Bacillus stearothermophilus - Answer D An unusual behavior that may be noticed in approximately 20% of gerbils is ________. a) Circling b) Seizures c) Stomping d) Hibernation - Answer B The normal gestation length for the rat is _________ days. a) 19- 21 b) 24- 26 c) 31- 33 d) 42- 45 - Answer A Intraperitoneal means ____________________________. a) In the muscle b) Into the abdominal cavity c) Into a vein d) Under the skin - Answer B When a gas anesthetic is given to an animal via an endotracheal tube, the route of administration is said to be _______________________. a) Inhalational b) Intravenous c) Topical d) Intraperitoneal - Answer A What is the main difference between gnotobiotic and germfree animals? a) There is no difference b) Gnotobiotic animals are given specific bacteria to aid in digestion c) Gnotobiotic animals are raised in isolators d) Germfree animals are only free of viruses - Answer B In birds, the reproductive, digestive and urinary tracts all terminate in a common opening known as the ________________. a) Crop b) Cloaca c) Ceca d) Carapace - Answer B Animals that are known to be free of specific pathogens, but may not be free of other pathogens are called? a) SPF b) VAF c) Germfree
d) Defined flora - Answer A Any living thing which can carry a disease is known as a? a) Contagion b) Fomite c) Vector d) Index case - Answer C A special dietary component for birds that is composed of oyster shell and granite is called _______________. a) grit b) gizzard c) gravel d) dirt - Answer A The normal gestation length for the domestic pig is _____ days. a) 65 b) 114 c) 145 d) 160 - Answer B The normal gestation length for the cat or dog is _________ days. a) 42- 45 b) 60- 65 c) 80- 85 d) 150- 175 - Answer B Which of the following is a vector? a) Mosquito b) Broom c) Lab coat d) Cage - Answer A What is the recommended acclimation period for rodents to recover from the stress of shipment? a) None b) 24 hours c) 48 hours d) 72 hours - Answer C The scientific name of the guinea pig is _______ _________. a) Mesocricetus auratus b) Rattus norvegicus c) Mus musculus d) Cavia porcellus - Answer D Which of the following nutrients is essential for guinea pigs, nonhuman primates and humans to prevent the development of scurvy? a) Vitamin B b) Vitamin C
The scientific name of the domestic pig is _______ _________. a) Capra hircus b) Ovis aries c) Sus scrofa d) Cavia porcellus - Answer C Which common respiratory pathogen of dogs and rabbits may cause severe clinical disease in guinea pigs? a) Herpesvirus tamarinus b) Parainfluenza c) Bordetella bronchiseptica d) Pasteurella multocida - Answer C What does the acronym MHV stand for? a) Mouse Herpes Virus b) Mouse Hepatitis Virus c) Murine Helicobacter Virus d) Marc Hulin Virus - Answer B Which of the following is a highly contagious infectious disease of mice, which can cause mortality in neonatal mice and adverse immunologic effects on research projects? a) Sendai virus b) MHV c) MPV d) Hantavirus - Answer B The scientific name of the Golden Syrian Hamster is _______ _________. a) Mesocricetus auratus b) Rattus norvegicus c) Mus musculus d) Cavia porcellus - Answer A The genus and species of the rhesus monkey is _______ _________. a) Cercocebus torquatus atys b) Callithrix jacchus c) Saimiri scurieus d) Macaca mulatta - Answer D The correct name for shoebox-type plastic cages that have a hard plastic lid fitted with a special filter is? a) Microisolator cage b) Biocontainment cage c) Hanging plastic cage d) Mini-isolator cage - Answer A A mouse with the genotype AaBBcc has which of the following phenotypes? a) Black
b) Brown c) Albino d) Agouti - Answer C Which of the following is a direct cost? a) Equipment depreciation b) Physical plant maintenance c) Electricity d) Animal husbandry - Answer D __________________ is the study of animals with completely known microflora and fauna. a) Histology b) Microbiology c) Gnotobiology d) Rumenology - Answer C The most popular anticoagulant for routine hematology testing is _________. a) EDTA b) Sodium heparin c) Sodium citrate d) Low molecular weight heparin - Answer A The best tissue preservative to use during routine necropsy is ____________. a) 15% Bouins solution b) 20% Liquid nitrogen c) 10% buffered formalin d) 10% alcohol - Answer C The USDA is required to inspect research facilities at least: a) Quarterly b) Semi-annually c) Annually d) Once every two years - Answer C The use of ______________ in an autoclave is the most common method of sterilization. a) Boiling water b) Chemicals c) Gamma radiation d) Steam under pressure - Answer D Which of the following genuses is not covered under the Animal Welfare Act? a) Meriones b) Mus c) Chinchilla d) Macaca - Answer B
Which of the following is the best method to create an induced immunodeficiency animal model? a) Spontaneous mutation b) Surgery c) Chemical d) Irradiation - Answer D Pseudomonas aeruginosa is a common opportunistic pathogen found in water supplies. Therefore, water supplies offered to immunocompromised animals should be autoclaved, chlorinated, or ________ to prevent the growth of this organism. a) Neutralized b) Basic c) Acidified d) Stabilized - Answer C The gestation period of the guinea pig is approximately ____ days. a) 24- 26 b) 31- 33 c) 59- 72 d) 150- 175 - Answer C A(n) ___________ is a substance, which enhances the antibody response. a) Additive b) Adjuvant c) Adjective d) Cathartic - Answer B What is the scientific term used to describe the collection of a sterile urine sample from the bladder? a) cholecystocentesis b) thoracentesis c) abdominocentesis d) cystocentesis - Answer D The average gestation length in sheep and goats is _____________ months. a) 3 b) 4 c) 5 d) 6 - Answer C An official USDA tag must have all of the following except: a) Identification number b) "USDA" letters c) Numbers and letters identifying the state and dealer d) Animal's date of birth - Answer D
The normal gestation length for the hamster is _________ days. a) 15- 16 b) 19- 21 c) 24- 26 d) 31- 33 - Answer A _______ ________ is the most frequently used laboratory animal in behavioral research and ________ _________ are also frequently used in this type of research. a) Mus musculus; Mesocricetus auratus b) Meriones unguiculatus; Cavia porcellus c) Rattus norvegicus; Columba livia d) Macaca mulatta; Oryctolagus cuniculus - Answer C The common name for Xenopus laevis is ____________. a) Bullfrog b) Tiger salamander c) Leopard frog d) African clawed frog - Answer D The minimum interior or height of a rabbit enclosure must be _________. a) 12 inches b) 14 inches c) 16 inches d) 18 inches - Answer B The common name for Oryctolagus cuniculus is _____________. a) Mongolian Gerbil b) Siberian Hamster c) Blackfooted Ferret d) New Zealand White Rabbit - Answer D The shelf life of a bag of standard laboratory ferret diet is __________ days after the _________ date. a) 60; shipping b) 90; milling c) 120; shipping d) 180; milling - Answer D How many milligrams of Domitor need to be given to a 15kg beagle, if the dosage for Domitor to sedate a dog is 30 mg/lb? a) 150 mg b) 450 mg c) 900 mg d) 1500 mg - Answer C How many milliliters of amoxicillin should a 5.5kg cat receive if the dosage is 10 mg/kg and the bottle of amoxicillin is a 5% solution? a) 1.1 ml b) 2.5 ml
